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Bacterium that causes gum disease delivers one-two punch by triggering protective proteins in oral cavity

The newly discovered bacterium that causes gum disease delivers a one-two punch by also triggering normally protective proteins in the mouth to actually destroy more bone, a University of Michigan study found.

12 Jun 2013

Study reveals radioimmunotherapy can improve survival rates of patients with aggressive lymphoma

A new patient protocol for aggressive and recurrent lymphoma that combines intensive chemotherapy and radioimmunotherapy (RIT) may become the most powerful cancer-killing therapy available, with the hope that patients' lymphoma can be eradicated as they prepare for bone marrow transplant, say researchers at the 2013 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging.

12 Jun 2013

New imaging system combines PET and MR for mapping recurrent prostate cancer

When prostate cancer makes a comeback, it becomes increasingly important to have exceptional imaging available to find all possible regions where cancer has spread to other parts of the body, or metastasized, in order to plan the best possible treatment.

12 Jun 2013

Celgene announces positive results from first phase III study of apremilast in psoriatic arthritis

Celgene International Sàrl, a wholly-owned subsidiary of Celgene Corporation, today announced 52-week results from PALACE 1, the Company's first phase III study in psoriatic arthritis at the European Congress of Rheumatology annual meeting in Madrid, Spain.

12 Jun 2013

Tumor suppressor p53 inactivation and restoration: an interview with Dr. Xin Lu, Ludwig Institute for Cancer Research

Before we talk about p53, it is important to understand why cancer cells are a problem for the body. Cancer cells multiply recklessly, refuse to die and blithely metastasize to set up shop in places where they don’t belong.

12 Jun 2013

First Edition: June 12, 2013

Today's headlines include reports about how the health law's implementation played in a recent town hall meeting as well as the action taken by one business in anticipation of its some of the requirements that will take effect in 2014.

12 Jun 2013

Researchers to launch Phase II clinical trial to investigate potential new therapy for sickle cell anemia

Seeking to improve the lives of sickle cell anemia sufferers around the world, researchers from the La Jolla Institute for Allergy and Immunology, the Dana-Farber/Children's Hospital Cancer Center in Boston and the BloodCenter of Wisconsin in Milwaukee and others are preparing to launch Phase II of a clinical trial to investigate a potential new therapy for reducing the disorder's severest symptoms.

12 Jun 2013

Home treatment improves chronic constipation in children

Home treatment with a simple, battery-operated system that applies four sticky electrode patches to the mid-section allowed a group of children with the most difficult-to-treat, possibly congenital, constipation to reduce soiling and improve elimination, according to results presented today at the 11th World Congress of the International Neuromodulation Society.

12 Jun 2013

Neuromodulators provide guidelines for implantation of "digital drugs" to manage chronic pain

Neuromodulators have joined together in the Neuromodulation Appropriateness Consensus Committee (NACC) to provide the first coordinated set of recommendations about patient selection and appropriateness for implantation of "digital drugs" to manage chronic pain.

12 Jun 2013

Hebrew University student develops drug formulations to treat illnesses through skin applications

New, more efficient drug formulations designed to treat illnesses through skin applications -- thus avoiding serious side effects associated with oral drug-taking -- have been developed by a student at the Hebrew University of Jerusalem.

12 Jun 2013

Mayo Clinic announces first US stem cell clinical trial for children with hypoplastic left heart syndrome

Mayo Clinic has announced the first U.S. stem cell clinical trial for pediatric congenital heart disease. The trial aims to determine how stem cells from autologous umbilical cord blood can help children with hypoplastic left heart syndrome, a rare defect in which the left side of the heart is critically underdeveloped.

12 Jun 2013

Two studies shed light on joint replacement outcomes in rheumatoid arthritis patients

Two new studies by researchers at Hospital for Special Surgery have shed light on joint replacement outcomes in patients with rheumatoid arthritis. One study overturns the common belief that RA patients have worse outcomes after a total knee replacement than patients who undergo the operation for osteoarthritis. The other study demonstrates that RA patients who undergo a total hip replacement were as likely to have significant improvements in function and pain as patients with osteoarthritis, even though they did not do as well.

12 Jun 2013

Countrywide study in Germany deems PRRT as life-prolonging treatment for patients with NETs

Peptide-receptor radionuclide therapy has been a subject of growing research on neuroendocrine tumors, which take up residence in a variety of organs replete with nerve cells that respond to hormone signaling.

12 Jun 2013

Studies demonstrate that combined therapy could destroy drug-resistant cells within melanoma tumor

Advanced metastatic melanoma is a disease that has proven difficult to eradicate. Despite the success of melanoma-targeting drugs, tumors inevitably become drug resistant and return, more aggressive than before. In the current issue of the journal Cancer Cell, however, researchers at The Wistar Institute describe how they increase the effectiveness of anti-melanoma drugs by combining anticancer therapies with diabetes drugs.

12 Jun 2013

Research finding offers new insight into stroke rehabilitation

A new study finds that stroke patients' brains show strong cortical motor activity when observing others performing physical tasks - a finding that offers new insight into stroke rehabilitation.

12 Jun 2013

Nimodipine reduces febrile seizures

Fever-induced childhood seizures, known as febrile seizures, can be terrifying for parents to witness. The full-body convulsions, which mostly affect children six months to five years old, can last from mere seconds up to more than 40 minutes. Currently, children are not treated with daily anticonvulsant medication to prevent these seizures even when they recur repeatedly because toxic side effects of existing treatments outweigh potential benefits.

12 Jun 2013

New weapon in the fight against childhood brain cancer emerges

A relatively new weapon in the fight against childhood brain cancer has emerged that improves upon standard magnetic resonance imaging by providing information about tumor metabolism and extent of cancer in children diagnosed with glioma, a growth caused by the abnormal division of glial cells in the brain, say researchers at the Society of Nuclear Medicine and Molecular Imaging's 2013 Annual Meeting.

11 Jun 2013

ARIAD Pharmaceuticals initiates ponatinib Phase 2 trial in adult patients with metastatic GIST

ARIAD Pharmaceuticals, Inc. today announced the initiation of the Phase 2 trial of Iclusig (ponatinib) in adult patients with metastatic and/or unresectable gastrointestinal stromal tumors.

11 Jun 2013

Prostate cancer and DNA: an interview with Dr. Jianfeng Xu, Wake Forest School of Medicine

Prostate cancer development is associated with both inherited and acquired genetic alterations. More than 70 inherited genetic variants have been consistently identified in human DNA that may contribute to susceptibility or risk of prostate cancer.

11 Jun 2013

UCLA study shows progesterone can be used as therapy for endometrial cancer

Progesterone, a female hormone that can be used as a therapy for endometrial cancer, eliminates tumor cells indirectly by binding to its receptor in stromal or connective tissue cells residing in the tumor microenvironment, according to a study from the G.O. Discovery Lab team and collaborators at UCLA.

11 Jun 2013

Therapy News and Research

Bacterium that causes gum disease delivers one-two punch by triggering protective proteins in oral cavity

Study reveals radioimmunotherapy can improve survival rates of patients with aggressive lymphoma

New imaging system combines PET and MR for mapping recurrent prostate cancer

Celgene announces positive results from first phase III study of apremilast in psoriatic arthritis

Tumor suppressor p53 inactivation and restoration: an interview with Dr. Xin Lu, Ludwig Institute for Cancer Research

First Edition: June 12, 2013

Researchers to launch Phase II clinical trial to investigate potential new therapy for sickle cell anemia

Home treatment improves chronic constipation in children

Neuromodulators provide guidelines for implantation of "digital drugs" to manage chronic pain

Hebrew University student develops drug formulations to treat illnesses through skin applications

Mayo Clinic announces first US stem cell clinical trial for children with hypoplastic left heart syndrome

Two studies shed light on joint replacement outcomes in rheumatoid arthritis patients

Countrywide study in Germany deems PRRT as life-prolonging treatment for patients with NETs

Studies demonstrate that combined therapy could destroy drug-resistant cells within melanoma tumor

Research finding offers new insight into stroke rehabilitation

Nimodipine reduces febrile seizures

New weapon in the fight against childhood brain cancer emerges

ARIAD Pharmaceuticals initiates ponatinib Phase 2 trial in adult patients with metastatic GIST

Prostate cancer and DNA: an interview with Dr. Jianfeng Xu, Wake Forest School of Medicine

UCLA study shows progesterone can be used as therapy for endometrial cancer

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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