Clinical Trial News and Research

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Semaglutide helps patients who gain weight after bariatric surgery

New UCL research supports use of the weight loss drug semaglutide for patients who do not get enough benefit from bariatric surgery.

22 May 2026

Weight loss helps older AF patients slim down, but does not ease symptoms

An 8-month low-calorie diet plus behavioral support helped older adults with overweight or obesity and persistent atrial fibrillation lose weight safely, with no intervention-related serious adverse events. However, the LOSE-AF trial found no meaningful improvement in AF symptoms, rhythm control, AF burden, cardiac remodeling, or further AF procedure rates compared with usual care.

22 May 2026

Oral drug improves platelet recovery during chemotherapy in gastrointestinal cancer patients

An oral medication already approved for thrombocytopenia in patients with liver disease significantly improved platelet recovery and helped patients with gastrointestinal cancers maintain platelet counts needed to continue chemotherapy as scheduled, according to results from a phase 2 clinical trial led by researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, and Mass General Hospital.

21 May 2026

Experimental virus therapy targets resistant high-grade neuroendocrine tumors

A phase I clinical trial is testing whether a tumor-targeting virus can help immunotherapy work more effectively against aggressive neuroendocrine tumors that often resist treatment.

21 May 2026

HonorHealth Research Institute tests steam therapy for diabetes treatment

HonorHealth Research Institute is looking to become the first research facility in the nation to begin a new clinical trial that aims to modify the lining of the digestive tract with the use of steam energy to control type II diabetes without the use of drugs.

21 May 2026

Structured approach to a healthy lifestyle may help slow important aspects of aging

Researchers at Wake Forest University School of Medicine found evidence of slowed aging from lifestyle behaviors like healthy eating and exercise as part of a major clinical trial.

21 May 2026

Phase two clinical trial demonstrates dramatic mobility gains in children with severe fibrous dysplasia

Fibrous dysplasia is a rare skeletal disorder in which normal bone is gradually replaced by weak fibro-osseous tissue, leading to fractures, pain, deformities, and severe mobility impairment. In many patients, diseased bone tissue produces excessive amounts of fibroblast growth factor-23 (FGF23), a hormone that causes phosphate loss through the kidneys.

21 May 2026

Oral AD109 improves sleep apnea severity but tolerability remains a challenge

AD109, an investigational once-daily oral combination of aroxybutynin and atomoxetine, significantly improved airway obstruction and oxygenation in adults with mild-to-severe obstructive sleep apnea who could not use PAP therapy. However, symptom improvements did not clearly differ from placebo, and about one in five AD109 recipients discontinued treatment due to adverse events.

21 May 2026

GLP-1 drugs may help curb addiction by targeting reward pathways

GLP-1 receptor agonists, already used for Type 2 diabetes and obesity, show promise in reducing alcohol and drug-seeking behaviors through central reward and dopamine-related pathways. Most evidence remains preclinical, with limited early human data, so larger clinical trials are needed before these drugs can be recommended for addiction treatment.

21 May 2026

Role of coronary revascularization in TAVI patients with severe aortic stenosis and CAD

The EuroPCR Course Directors have selected 3 major late-breaking trials that will be presented for the first time during EuroPCR 2026 and are set to impact practice worldwide.

20 May 2026

Cytokine-armored CAR-T cell therapy successfully attacks aggressive brain tumors in mice

Scientists at the UCLA Health Jonsson Comprehensive Cancer Center have developed a new cytokine-armored CAR-T cell therapy that helps the immune system better attack aggressive brain tumors in mice while reducing dangerous side effects that have long limited immune-based treatments for glioblastoma, one of the deadliest and most treatment-resistant brain cancers.

20 May 2026

Anti-inflammatory drug tocilizumab shows promise for difficult-to-treat depression

Immunotherapy could be a promising new treatment option for patients with difficult-to-treat depression. This is a key finding from a University of Bristol-led pilot randomised controlled clinical trial, published in JAMA Psychiatry today [20 May].

20 May 2026

Tumor microenvironment markers forecast immunotherapy response in rare cancers

A new study in Cell Reports Medicine from researchers at The University of Texas MD Anderson Cancer Center identified key features that may help predict which types of rare cancers are likely to respond to immunotherapy.

20 May 2026

Study links pediatric sedation strategies with later neurocognitive outcomes

A new Penn Nursing study suggests that the specific sedatives used during critical illness in early childhood may have long-term implications for a child's neurocognitive development.

19 May 2026

Real-world study compares leading ALK+ lung cancer treatments

A team of researchers from the Keck School of Medicine of USC, the USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences and the USC Shaeffer Center for Health Policy & Economics have conducted a head-to-head comparison of five leading treatments for anaplastic lymphoma kinase-positive (ALK+) non-small cell lung cancer.

19 May 2026

Switching to pod-based e-cigarette could improve the odds of quitting smoking

Cigarette smoking is the leading preventable cause of death in the United States, even as rates of cigarette smoking have fallen to an all-time low of approximately 10% in 2024.

19 May 2026

Researchers identity patients with exceptional tirzepatide response outcomes

Tirzepatide GLP-1 medication is known to improve sleep apnea for people with both obstructive sleep apnea (OSA) and obesity, but not all patients benefit equally.

19 May 2026

Molecular profiling initiative seeks to uncover late breast cancer recurrence mysteries

The ECOG-ACRIN Cancer Research Group (ECOG-ACRIN), in collaboration with the SWOG Cancer Research Network (SWOG), has launched a new initiative to analyze paired original and recurrent tumor specimens from two practice-changing breast cancer clinical trials.

19 May 2026

Combination therapy shows promise in maintaining lower suicidal thoughts over time

New research published online today in the American Journal of Psychiatry finds that low-dose buprenorphine, given after a single ketamine infusion, significantly sustained reductions in suicidal ideation in adults with major depressive disorder.

19 May 2026

Stem cell infusions improve symptoms in butterfly skin disease

The intravenous infusion of mesenchymal stem cells from family donors is safe and improves symptoms such as pruritus (itching), sleep disturbances, and fatigue associated with Recessive Dystrophic Epidermolysis Bullosa (RDEB), popularly known as "butterfly skin".

18 May 2026

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Clinical Trial News and Research

Semaglutide helps patients who gain weight after bariatric surgery

Weight loss helps older AF patients slim down, but does not ease symptoms

Oral drug improves platelet recovery during chemotherapy in gastrointestinal cancer patients

Experimental virus therapy targets resistant high-grade neuroendocrine tumors

HonorHealth Research Institute tests steam therapy for diabetes treatment

Structured approach to a healthy lifestyle may help slow important aspects of aging

Phase two clinical trial demonstrates dramatic mobility gains in children with severe fibrous dysplasia

Oral AD109 improves sleep apnea severity but tolerability remains a challenge

GLP-1 drugs may help curb addiction by targeting reward pathways

Role of coronary revascularization in TAVI patients with severe aortic stenosis and CAD

Cytokine-armored CAR-T cell therapy successfully attacks aggressive brain tumors in mice

Anti-inflammatory drug tocilizumab shows promise for difficult-to-treat depression

Tumor microenvironment markers forecast immunotherapy response in rare cancers

Study links pediatric sedation strategies with later neurocognitive outcomes

Real-world study compares leading ALK+ lung cancer treatments

Switching to pod-based e-cigarette could improve the odds of quitting smoking

Researchers identity patients with exceptional tirzepatide response outcomes

Molecular profiling initiative seeks to uncover late breast cancer recurrence mysteries

Combination therapy shows promise in maintaining lower suicidal thoughts over time

Stem cell infusions improve symptoms in butterfly skin disease

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