Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

Ozone exposure weakens lung function and reshapes the oral microbiome

Ozone exposure reshapes the oral microbiome and reduces lung function, particularly in men, revealing significant health risks associated with pollution.

1 Oct 2025

Khat use linked to autoimmune hepatitis in young men

Khat (Catha edulis), a plant chewed for its stimulant effects by millions in East Africa and the Arabian Peninsula, is increasingly recognized for its hepatotoxic potential.

30 Sep 2025

Engineers create designer biobots using human lung cells

A brand-new engineering approach to generate "designer" biological robots using human lung cells is underway in Carnegie Mellon University's Ren lab.

26 Sep 2025

Pediatric lung transplantation shows promising outcomes in China

Lung transplantation has transformed care for patients with end-stage respiratory failure, particularly among adults, where the number of procedures has grown dramatically over recent decades.

25 Sep 2025

Targeting TGF-β signaling as a strategy to treat liver fibrosis

Liver fibrosis, a pathological scarring process resulting from chronic liver injury, represents a significant global health burden due to its potential progression to cirrhosis and hepatocellular carcinoma.

25 Sep 2025

New screening method boosts efficiency and accuracy of CAST genome editing

Natural systems such as CRISPR-associated transposons (CASTs) offer a targetable, one-step way to edit genomes.

23 Sep 2025

Coffee protects the liver by blocking inflammation and scarring, review finds

A new review in Biochemical Pharmacology synthesizes decades of research showing consistent links between regular coffee consumption and reduced risk of liver disease, including cirrhosis and liver cancer. Coffee’s bioactive compounds act on antioxidant, anti-inflammatory, antifibrotic, and metabolic pathways to slow liver damage progression.

21 Sep 2025

POT1 gene mutation linked to pulmonary fibrosis through telomere dysfunction

Idiopathic pulmonary fibrosis is a potentially fatal disease currently without treatment, in which lung tissue develops scarring and becomes stiff, making breathing increasingly difficult over time.

18 Sep 2025

Innovative RNA editing offers hope beyond CRISPR

Genetic editing holds promise to treat incurable diseases, but the most popular method - CRISPR - sometimes does more harm than good.

18 Sep 2025

Breakthrough in building functional synthetic kidneys using assembloids

A USC Stem Cell-led research team has achieved a major step forward in the effort to build mouse and human synthetic kidneys.

17 Sep 2025

Neurons play a key role in reducing lung inflammation in pulmonary fibrosis

Researchers at the University of Calgary studying a lethal lung disease called pulmonary fibrosis have found neurons, which were known to help detect pain, are also critical for reducing harmful lung inflammation that leads to the disease.

16 Sep 2025

AI toolset reveals links between lung fibrosis and aging

A new research paper was published in Volume 17, Issue 8 of Aging-US on August 8, 2025, titled "AI-driven toolset for IPF and aging research associates lung fibrosis with accelerated aging."

11 Sep 2025

Researchers reveal why no level of air pollution is safe for respiratory health

A review in the Journal of Clinical Investigation shows how particulate matter damages the lungs through oxidative stress, inflammation, and immune disruption. It links air pollution to asthma, COPD, lung cancer, infections, and millions of premature deaths, with no safe exposure threshold.

9 Sep 2025

Researchers uncover a previously unknown mechanism behind chromosome end protection

Researchers have uncovered a previously unknown mechanism that safeguards the chromosome ends from being mistakenly repaired by the cell.

9 Sep 2025

New technology could make MRI scanners cost-effective and more accessible

Revolutionary new technology could make MRI scanners cost effective, more widely available to local communities and help save lives, thanks to a pioneering collaboration between the University of Sheffield and GE HealthCare.

8 Sep 2025

WHO expands essential medicines lists with new cancer and diabetes treatments

Today, the World Health Organization (WHO) has released updated editions of its Model Lists of Essential Medicines (EML) and Essential Medicines for Children (EMLc), adding new treatments for various types of cancer and for diabetes with associated comorbidities such as obesity.

5 Sep 2025

How mechanical changes in lung tissue trigger fibrosis

Fibrosis of the lungs is often a silent disease until it's too late. By the time patients are diagnosed, the scarring of their lung tissue is already advanced, and current treatments offer little more than a slowing of the inevitable.

5 Sep 2025

Single-cell transcriptomics reveals new players in liver regeneration

The liver is remarkable for its ability to regenerate after injury, yet when this process fails, acute liver failure (ALF) carries devastating outcomes.

2 Sep 2025

Glycosylation emerges as a key player in kidney disease progression

Kidney diseases affect nearly 700 million people worldwide and are a growing cause of mortality and health care costs.

29 Aug 2025

Qureight's AI 3D imaging platform to support Calluna Pharma's Phase 2 AURORA study of CAL101 in idiopathic pulmonary fibrosis (IPF)

Qureight, a techbio company advancing the understanding of lung and heart disease through application of its AI-powered imaging and clinical data curation platform, today announced that it has been selected by Calluna Pharma to support its Phase 2 AURORA study.

27 Aug 2025