Glycosylation News and Research

RSS

Sugar-attaching enzyme found to be abundant in colon cancer cells

Researchers have identified an enzyme that is absent in healthy colon tissue but abundant in colon cancer cells, according to a report in the Jan. 26 issue of the Journal of Biological Chemistry.

27 Jan 2018

Findings provide better understanding of thyroid hormones' role in mammalian seasonal changes

Researchers now have a better understanding of the role that thyroid hormones, the tissues that produce them, and the biochemical pathways on which they act have in driving seasonal reproduction in some mammals, and how this new information may help explain seasonal changes in metabolism and mood that affect humans.

21 Dec 2017

Russian researchers create new approaches to prevention and treatment of diabetes

A team of scientists from the Ural Federal University and the Institute of Immunology and Physiology modeled type 1 diabetes in an experiment to study recovery processes in the pancreas.

11 Dec 2017

Researchers seek to understand role of novel protein in tumor metastasis

Metastasis, the process in which a tumor spreads to other parts of the body, is responsible for 90% of deaths from tumors. It is the greatest challenge to a cancer patient's survival. Metastatic spread occurs in several steps, these include that tumor cells become mobile and cross into and out of blood vessels.

8 Dec 2017

Scientists use computer analysis to complete antibody blueprint

Antibodies defend our bodies against intruders. These molecules consist of proteins with attached sugars. However, the blueprint directing the processing of these sugars on the protein was not well understood until now.

30 Nov 2017

Study unveils new immunotherapeutic target against multiple myeloma

Osaka - In recent decades monoclonal antibody-based treatment of cancer has been established as one of the most successful therapeutic strategies for both solid tumors and blood cancers.

27 Nov 2017

Research reveals sugary secrets of protein important for development and cancer progression

The proteins in human cells are extensively decorated with different types of sugars, a phenomenon called glycosylation. These modifications greatly increase the diversity of protein structure and function, affecting how proteins fold, how they behave, and where they go in cells.

15 Sep 2017

Researchers pinpoint sugar modification in cells that spurs spread of skin cancer

A team of researchers has pinpointed a sugar modification in cells that spurs the spread of skin cancer. Its findings, which appear in the latest issue of the journal Cancer Cell, spotlight a target in the battle against melanoma.

13 Jun 2017

FARE announces recipients of 2017 Investigator in Food Allergy Awards

Food Allergy Research & Education, the world's largest private source of funding for food allergy research, is pleased to announce the recipients of the 2017 FARE Investigator in Food Allergy Awards after an extraordinarily competitive review process, with more than two dozen researchers submitting high-quality proposals.

22 Mar 2017

Octapharma uses G:BOX Chemi XX6 imager to accurately characterise large therapeutic proteins

Syngene, a world-leading manufacturer of image analysis solutions, is pleased to announce its G:BOX Chemi XX6 multi-application-functional imager is being utilised by scientists at major human protein R&D company, Octapharma Biopharmaceuticals GmbH in Germany for analysing a range of large proteins.

From Syngene 17 Mar 2017

Scientists identify genetic clues to chronic kidney disease

Using international genomic studies backed by proof-of-concept cell experiments, researchers have identified two genes that contribute to the chronic kidney disease glomerulonephritis.

16 Mar 2017

New technique opens door for biochemists to create better therapeutic antibodies

Antibodies are the foot soldiers of our immune system. These specialized, Y-shaped proteins attach to bacteria and viruses, where they either block the pathogen's activity directly, or signal the immune system's cells to destroy the invader.

14 Mar 2017

Bruker showcases innovative high-performance systems and high-value analytical solutions at Pittcon 2017

Bruker (NASDAQ: BRKR) is showcasing a selection of innovative high-performance systems and high-value analytical solutions at Pittcon 2017 (www.pittcon.org), with an emphasis on pharma and applied markets, as well as on nano-materials research and microscopy.

From Bruker BioSpin Group 7 Mar 2017

Researchers uncover new genetic clues linked to autoimmune kidney disease

Researchers have uncovered new genetic clues to understanding IgA nephropathy (IgAN), or Berger's disease, an autoimmune kidney disease and a common cause of kidney failure.

6 Mar 2017

Researcher develops new method to accurately identify elusive molecules

Among the most important molecules in the living world are sugars or carbohydrates, which play a vital role in life processes. Sugars provide the main source of fuel for the body, protect muscles from damage and contribute to the immune response.

21 Dec 2016

Yale researchers identify chemical inhibitor that limits growth of lung tumor cells

A recently published Yale study may offer a new solution to fighting lung cancer.

20 Oct 2016

Antibody protection may help control infection caused by TB bacteria

A study led by investigators from the Ragon Institute of MGH, MIT and Harvard finds evidence that antibody protection may help control infection with the bacteria that causes tuberculosis (TB).

4 Oct 2016

New CWRU study identifies three glycosyltransferases as major mutational targets in colorectal cancer

Little is known about the molecular basis of aberrant protein glycosylation, a complex enzymatic process that is a hallmark of many human cancers including colorectal cancers (CRC), and how it may contribute to tumor progression. In a new study published in Scientific Reports, an online journal of the Nature Publishing Group, scientists at Case Western Reserve University School of Medicine have successfully characterized the mutational landscapes of glycosylation-associated genes in colon cancer, identifying three glycosyltransferases as significant mutational targets in CRC.

4 Apr 2016

Purdue University-led researchers determine structure of Zika virus

A team led by Purdue University researchers is the first to determine the structure of the Zika virus, which reveals insights critical to the development of effective antiviral treatments and vaccines.

1 Apr 2016

New tests could improve diagnosis of two rare childhood diseases

For the first time, researchers have developed tests that could improve the diagnosis of two rare childhood diseases known as congenital disorders of glycosylation (CDGs) and metachromatic leukodystrophy, and that could even lead to new treatments for CDGs.

5 Jan 2016