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Insignificant homology of SARS-CoV-2 spike sequences to myocarditis-associated antigens

Researchers determine whether sequences within SARS-CoV-2 could lead to an immune response to autoantigens associated with autoimmune myocarditis.

13 Jan 2022

Lack of evidence cross-reactive adaptive immune response is mechanism underlying COVID vaccine-induced myocarditis

Recently, the researchers from the USA, in their study published in the journal EBioMedicine, have conducted a sequence identity comparison and 3D protein structure comparison between the SARS-CoV-2 spike protein-derived peptides/protein and myocarditis-associated antigens and have found no significant enrichment in the frequency of spike-derived peptides similar to myocarditis-associated antigens that could have resulted in adaptive autoimmune responses leading to myocarditis.

12 Jan 2022

Withdrawing steroid treatment found to boost SARS-CoV-2 vaccine-induced immunity in kidney transplant recipients

In a new study, a team of researchers investigated the impact of the fourth dose of a vaccine against COVID-19 in kidney transplant recipients, who had not mounted a humoral immune response to three doses of vaccine.

11 Jan 2022

Study finds T cell response mostly conserved against SARS-CoV-2 Omicron variant following infection or vaccination

A new preprint examines the extent of protection offered by T cell responses to primary vaccination and/or natural infection with the virus.

11 Jan 2022

Study finds heterologous vaccine booster evokes robust immunity to SARS-CoV-2 Omicron variant

The current study examines the role of heterologous vaccination, an area that lacks much clarity.

11 Jan 2022

Neutralization of SARS-CoV-2 variants by three-dose mRNA vaccinated kidney transplant recipient sera

In a new study, researchers determined three-dose messenger ribonucleic acid (mRNA) vaccinated kidney transplant recipients’ (KTRs) neutralizing responses against SARS-COV-2 variants, breakthrough coronavirus disease 2019 infection rate, and transplant rejection rate.

10 Jan 2022

SARS-CoV-2 Omicron belongs to new antigenic cluster compared to all other VOCs

Researchers investigate SARS-CoV-2 antigenic drift by evaluating the neutralizing activity of sera from patients infected with all five SARS-CoV-2 VOCs.

6 Jan 2022

Scientists assess effectiveness of neutralizing antibodies against seven SARS-CoV-2 variants, including Omicron

Researchers determine the neutralization potency of serum from COVID-19-recovered patients and double-vaccinated individuals against SARS-CoV-2 variants.

6 Jan 2022

Antibody binding response significantly reduced for Omicron compared to other SARS-CoV-2 variants

Researchers analyzed ACE2-binding inhibition and antibody binding for the SARS-CoV-2 Omicron variants in individuals with varying levels of immunity.

6 Jan 2022

Comparison of neutralization of SARS-CoV-2 variants of concern Omicron and Delta

The purpose of this study was to determine the breadth of neutralizing activity generated by exposure to certain SARS-CoV-2 variants, vaccinations, or both.

6 Jan 2022

SARS-CoV-2 Omicron variant highly resistant to vaccine-elicited and therapeutic antibodies

Researchers analyzed convalescent sera and sera from immunized individuals to demonstrate the evasion of antibodies by the SARS-CoV-2 Omicron variant.

3 Jan 2022

SARS-CoV-2 Omicron study on hamsters, shows virus results in a less severe disease

Researchers investigate the ability of immunity acquired from SARS-CoV-2 wild-type infection to protect against the Omicron variant in Syrian hamster models.

3 Jan 2022

Impact of a pan-sarbecovirus dendritic-cell targeting vaccine on SARS-CoV-2 variants

A new study used in silico approaches for designing a next-generation CD40-targeting vaccine, CD40.

31 Dec 2021

COVID mRNA vaccines show diminished neutralization responses against Omicron

Researchers report an overview of antibody neutralization by all currently approved vaccines against the SARS-CoV-2 Omicron, Beta, and Delta VOCs.

29 Dec 2021

Exploring immunogenicity and safety after a homologous booster dose of SARS-CoV-2 recombinant spike protein vaccine

Research suggests that a single booster dose of NVX-CoV2373 given approximately six months after the primary series induced significant increases in humoral antibodies, while also exhibiting an acceptable safety profile.

29 Dec 2021

Efficacy of SARS-CoV2 variant-specific replicating RNA vaccines on SARS-CoV-2 variants of concern

A new study evaluates the repRNA vaccine expressing the SARS-CoV-2 spike protein for the B.1.1.7 and B.1.351 variants in mice and hamsters.

19 Dec 2021

Study says COVID mRNA-based vaccines best for booster vaccination

A new study looks at the adaptive immune response to COVID-19 vaccines, wherein the authors compare heterologous to homologous immunization.

19 Dec 2021

Omicron variant may strike double vaccinated

Largely, scientists are skeptical that the Omicron variant can infect vaccinated individuals. However, a new study published on the medRxiv* preprint server has conducted neutralization assays using an Omicron isolate obtained from patients residing in the United Kingdom.

13 Dec 2021

Characteristics of vaccine breakthroughs in fully vaccinated individuals in France with delta variant

In a recent observational study, scientists have described the characteristics of VBIs in fully vaccinated individuals in France.

13 Dec 2021

SARS-CoV-2 omicron variant may evade host immune responses

A recent study has demonstrated that the omicron variant of severe acute respiratory syndrome coronavirus 2 has a higher ability to evade antibody-mediated neutralization than other variants of concern.

13 Dec 2021

Homologous News and Research

Insignificant homology of SARS-CoV-2 spike sequences to myocarditis-associated antigens

Lack of evidence cross-reactive adaptive immune response is mechanism underlying COVID vaccine-induced myocarditis

Withdrawing steroid treatment found to boost SARS-CoV-2 vaccine-induced immunity in kidney transplant recipients

Study finds T cell response mostly conserved against SARS-CoV-2 Omicron variant following infection or vaccination

Study finds heterologous vaccine booster evokes robust immunity to SARS-CoV-2 Omicron variant

Neutralization of SARS-CoV-2 variants by three-dose mRNA vaccinated kidney transplant recipient sera

SARS-CoV-2 Omicron belongs to new antigenic cluster compared to all other VOCs

Scientists assess effectiveness of neutralizing antibodies against seven SARS-CoV-2 variants, including Omicron

Antibody binding response significantly reduced for Omicron compared to other SARS-CoV-2 variants

Comparison of neutralization of SARS-CoV-2 variants of concern Omicron and Delta

SARS-CoV-2 Omicron variant highly resistant to vaccine-elicited and therapeutic antibodies

SARS-CoV-2 Omicron study on hamsters, shows virus results in a less severe disease

Impact of a pan-sarbecovirus dendritic-cell targeting vaccine on SARS-CoV-2 variants

COVID mRNA vaccines show diminished neutralization responses against Omicron

Exploring immunogenicity and safety after a homologous booster dose of SARS-CoV-2 recombinant spike protein vaccine

Efficacy of SARS-CoV2 variant-specific replicating RNA vaccines on SARS-CoV-2 variants of concern

Study says COVID mRNA-based vaccines best for booster vaccination

Omicron variant may strike double vaccinated

Characteristics of vaccine breakthroughs in fully vaccinated individuals in France with delta variant

SARS-CoV-2 omicron variant may evade host immune responses

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