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Already approved drug avapritinib shows promise in treating high-grade gliomas

High-grade glioma, an aggressive form of pediatric and adult brain cancer, is challenging to treat given the tumor location, incidence of recurrence and difficulty for drugs to cross the blood-brain barrier.

13 Mar 2025

Researchers uncover 195 genetic risk factors driving women’s reproductive diseases

Scientists identified 195 genetic risk loci across 42 female reproductive health conditions, revealing shared genetic pathways and developing a polygenic risk score for intrahepatic cholestasis of pregnancy (ICP). These findings pave the way for personalized reproductive healthcare and targeted treatments based on genetic risk.

12 Mar 2025

Cordycepin helps tired mice run longer and think better, study finds

Researchers show that cordycepin, a compound from Cordyceps militaris, can boost endurance and protect brain function in mice exhausted by excessive exercise.

10 Mar 2025

Unraveling the genetic differences between LUAD and LUSC in lung cancer

Lung cancer remains one of the leading causes of cancer-related mortality, with lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) representing the most prevalent subtypes of non-small cell lung cancer (NSCLC).

8 Mar 2025

Insilico Medicine's AI-driven drug Rentosertib receives official generic name

Insilico Medicine("Insilico"), a clinical stage generative artificial intelligence (AI)-driven biotechnology company, recently announced that its breakthrough drug candidate for idiopathic pulmonary fibrosis (IPF) – Rentosertib (formerly known as ISM001-055) – has been granted an official generic name by the United States Adopted Names (USAN) Council.

7 Mar 2025

Scientists uncover structure of key enzyme to block cancer cell energy supply

Cancer cells have an insatiable appetite for energy as they multiply more rapidly than normal cells. Greedy cancer cells hijack various cellular functions to find and exploit energy and other resources, including a group of enzymes that help normal cells maintain a balance of energy.

6 Mar 2025

Novel mechanism of PDHX acetylation linked to hepatocellular carcinoma progression

Cancer cells are known to favor aerobic glycolysis for energy production, a phenomenon termed the Warburg effect.

3 Mar 2025

Intermittent fasting cuts heart attack risk by preventing dangerous blood clots

Intermittent fasting may reduce the risk of blood clots and cardiovascular disease by inhibiting platelet activation.

2 Mar 2025

Scientists uncover how herpes virus fuels Alzheimer’s disease

Herpesvirus infection may contribute to Alzheimer’s disease through transposable element activation and neuroinflammation.

2 Mar 2025

Review sheds light on the mechanistic role of long non-coding RNAs in liver disease

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a global health challenge, affecting nearly 30% of adults worldwide.

28 Feb 2025

Advancements in molecular diagnostics for hematopoietic and lymphocytic neoplasms

Hematopoietic and lymphocytic neoplasms (HLNs) are a diverse group of malignancies affecting blood and lymphatic systems, with outcomes varying from manageable conditions to fatal diseases.

27 Feb 2025

Artificial sweeteners may reduce metformin’s effectiveness in weight and glucose control

Drinking artificially sweetened beverages may reduce metformin’s effectiveness in young patients with obesity and prediabetes, but a larger study is needed to confirm these findings.

27 Feb 2025

Innovative combination of treatments effectively kills acute myeloid leukemia cells

Scientists at VCU Massey Comprehensive Cancer Center have identified an innovative combination of treatment strategies that work collaboratively to effectively kill acute myeloid leukemia (AML) cells, a frequently incurable form of cancer.

27 Feb 2025

Review highlights next-generation cancer therapies targeting PIK3CA mutations

A newly published review in Genes & Diseases explores the oncogenic activation of PIK3CA in cancer and highlights emerging targeted therapies designed to improve treatment efficacy while reducing side effects.

25 Feb 2025

Unveiling the role of FAM20C in disease and cancer treatment

A new review published in Genes & Diseases explores the multifaceted role of FAM20C, a Golgi protein kinase, in disease progression.

23 Feb 2025

Exploring the dual role of LKB1 in tumor suppression and promotion

Mutations in serine-threonine kinase 11 (STK11) and liver kinase B1 (LKB1) are associated with disease progression in Peutz-Jeghers syndrome (PJS), which can progress to cancer.

22 Feb 2025

AI-driven discovery unveils TNIK inhibition as anti-aging strategy

A groundbreaking study led by researchers at Insilico Medicine has revealed the potential of TNIK inhibition as an innovative anti-aging strategy.

22 Feb 2025

CBD boosts endurance in mice by reshaping gut bacteria and enhancing muscle performance

Study shows that cannabidiol (CBD) enhances endurance exercise in mice by reshaping gut microbiota, boosting mitochondrial function, and altering muscle fiber composition for improved performance.

20 Feb 2025

Unfolded protein response disruptions contribute to colorectal cancer and gut-related disorders

The intestinal epithelium is a highly dynamic barrier that regulates digestion, absorption, immune responses, and communication between the gut microbiota and the nervous system.

20 Feb 2025

CPRIT awards nearly $23 million to MD Anderson for cancer research projects

The University of Texas MD Anderson Cancer Center today was awarded nearly $23 million from the Cancer Prevention and Research Institute of Texas (CPRIT) in support of 20 cancer research projects to advance new breakthroughs in discovery, translational, clinical and prevention science.

20 Feb 2025

Kinase News and Research

Already approved drug avapritinib shows promise in treating high-grade gliomas

Researchers uncover 195 genetic risk factors driving women’s reproductive diseases

Cordycepin helps tired mice run longer and think better, study finds

Unraveling the genetic differences between LUAD and LUSC in lung cancer

Insilico Medicine's AI-driven drug Rentosertib receives official generic name

Scientists uncover structure of key enzyme to block cancer cell energy supply

Novel mechanism of PDHX acetylation linked to hepatocellular carcinoma progression

Intermittent fasting cuts heart attack risk by preventing dangerous blood clots

Scientists uncover how herpes virus fuels Alzheimer’s disease

Review sheds light on the mechanistic role of long non-coding RNAs in liver disease

Advancements in molecular diagnostics for hematopoietic and lymphocytic neoplasms

Artificial sweeteners may reduce metformin’s effectiveness in weight and glucose control

Innovative combination of treatments effectively kills acute myeloid leukemia cells

Review highlights next-generation cancer therapies targeting PIK3CA mutations

Unveiling the role of FAM20C in disease and cancer treatment

Exploring the dual role of LKB1 in tumor suppression and promotion

AI-driven discovery unveils TNIK inhibition as anti-aging strategy

CBD boosts endurance in mice by reshaping gut bacteria and enhancing muscle performance

Unfolded protein response disruptions contribute to colorectal cancer and gut-related disorders

CPRIT awards nearly $23 million to MD Anderson for cancer research projects

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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