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Changes in OASI gene expression increases risk of Alzheimer's and severe COVID-19 infection

Previous research identified the interferon-responsive OAS1 gene as a risk gene for Alzheimer's disease. OAS1 is an enzyme that binds to double-stranded RNA and induces the conformation to create oligoadenylates. They also activate RNase L to break down RNA.

23 Mar 2021

Optimized nano-micelles can induce efficient genome editing in the mouse brain

The research group of Deputy Principal Research Scientist Dr. Satoshi Uchida (Associate Professor, Kyoto Prefectural University of Medicine) at the Innovation Center of NanoMedicine (Director General: Prof. Kazunori Kataoka, Location: Kawasaki-Japan, Abbreviation: iCONM) reported that optimized nano-micelles can induce efficient genome editing in the mouse brain.

12 Mar 2021

Optimized nano-micelles can induce efficient genome editing in the mouse brain

12 Mar 2021

New research project aims to treat patients with secondary brain damage

The Universities of Birmingham and Cambridge have launched a new research project aimed at discovering if selective P2X7 receptor blocker drugs can be repurposed to treat patients with secondary brain damage.

9 Mar 2021

Inhibition of complement disrupts neurodegeneration, improves cognitive function in TBI patients

Traumatic brain injury (TBI) is a major cause of disability and a risk factor for early-onset dementia. The injury is characterized by a physical insult followed acutely by complement driven neuroinflammation.

9 Mar 2021

Neuroinvasiveness of SARS-CoV-2 shown by viral RNA and inflammation in the brain

A new study describes the results of a macaque study that showed the development of neurological features of inflammation, following infection by SARS-CoV-2.

25 Feb 2021

Study offers new insights into "Niemann-Pick type C disease"

In the journal Nature Communications, scientists of the German Center for Neurodegenerative Diseases (DZNE) report new findings on the mechanisms of "Niemann-Pick type C disease" (NPC).

24 Feb 2021

3D microscopy analysis provides accurate recreation of human glioblastoma’s features

Researchers at the Institut de Neurociències obtained a highly accurate recreation of human glioblastoma’s features using a novel 3D microscopy analysis

19 Feb 2021

Researchers identify antibody that removes amyloid plaques without the risk of brain bleeds

As people age, a normal brain protein known as amyloid beta often starts to collect into harmful amyloid plaques in the brain. Such plaques can be the first step on the path to Alzheimer's dementia.

18 Feb 2021

Simulating an overactive autoimmune response leads to changes in the brain region

Researchers at the University of Tsukuba in Japan show that simulating an overactive autoimmune response in mice leads to changes in the hippocampal region of the brain.

17 Feb 2021

Study finds locations of early prion protein accumulation in the eye

The earliest eye damage from prion disease takes place in the cone photoreceptor cells, specifically in the cilia and the ribbon synapses, according to a new study of prion protein accumulation in the eye by National Institutes of Health scientists.

29 Jan 2021

Microglial cells contribute to the negative mood experienced during neurological diseases

Special immune cells found in the brain, microglia, play a key role in the processes that make you feel uneasy and depressed in correlation with inflammation.

26 Jan 2021

Study: Oligodendrocytes play key role in the distribution of energy-rich molecules

The human brain has about as many neurons as glial cells. These are divided into four major groups: the microglia, the astrocytes, the NG2 glial cells, and the oligodendrocytes.

19 Jan 2021

Timing may be critical when administering treatment after brain injury

Researchers from the National Institutes of Health have discovered Jekyll and Hyde immune cells in the brain that ultimately help with brain repair but early after injury can lead to fatal swelling, suggesting that timing may be critical when administering treatment.

18 Jan 2021

Researchers identify the missing link between intestinal disease and brain injury in premature infants

Physicians have long known that necrotizing enterocolitis (NEC), a potentially lethal inflammatory condition that destroys a premature infant's intestinal lining, is often connected to the development of severe brain injury in those infants who survive.

6 Jan 2021

Researchers discover novel therapeutic strategy for ischemic stroke using experimental model

Research conducted at LSU Health New Orleans Neuroscience Center of Excellence reports that a combination of an LSU Health-patented drug and selected DHA derivatives is more effective in protecting brain cells and increasing recovery after stroke than a single drug. The findings are published in Brain Circulation, available here.

4 Jan 2021

Brain damage is not caused by direct COVID-19 attack, indicates study

n an in-depth study of how COVID-19 affects a patient's brain, National Institutes of Health researchers consistently spotted hallmarks of damage caused by thinning and leaky brain blood vessels in tissue samples from patients who died shortly after contracting the disease.

3 Jan 2021

Researchers find mechanism underlying plasticity in adult brains

Developing brains constantly sprout new neuronal connections called synapses as they learn and remember. Important connections — the ones that are repeatedly introduced, such as how to avoid danger — are nurtured and reinforced, while connections deemed unnecessary are pruned away.

24 Dec 2020

Alterations in fetal microglia may lead to developmental and psychiatric disorders

Researchers at the Kobe University Graduate School of Medicine have revealed that alterations in fetal microglia resulting from maternal inflammation could contribute towards the onset of developmental and psychiatric disorders.

23 Dec 2020

Trinity team uncovers mutations linked with early onset dementia

Scientists at Trinity College Dublin today announced a significant advance in our understanding of an early onset form of dementia that may also progress our understanding of conditions such as Alzheimer's disease.

22 Dec 2020

Microglia News and Research

Changes in OASI gene expression increases risk of Alzheimer's and severe COVID-19 infection

Optimized nano-micelles can induce efficient genome editing in the mouse brain

Optimized nano-micelles can induce efficient genome editing in the mouse brain

New research project aims to treat patients with secondary brain damage

Inhibition of complement disrupts neurodegeneration, improves cognitive function in TBI patients

Neuroinvasiveness of SARS-CoV-2 shown by viral RNA and inflammation in the brain

Study offers new insights into "Niemann-Pick type C disease"

3D microscopy analysis provides accurate recreation of human glioblastoma’s features

Researchers identify antibody that removes amyloid plaques without the risk of brain bleeds

Simulating an overactive autoimmune response leads to changes in the brain region

Study finds locations of early prion protein accumulation in the eye

Microglial cells contribute to the negative mood experienced during neurological diseases

Study: Oligodendrocytes play key role in the distribution of energy-rich molecules

Timing may be critical when administering treatment after brain injury

Researchers identify the missing link between intestinal disease and brain injury in premature infants

Researchers discover novel therapeutic strategy for ischemic stroke using experimental model

Brain damage is not caused by direct COVID-19 attack, indicates study

Researchers find mechanism underlying plasticity in adult brains

Alterations in fetal microglia may lead to developmental and psychiatric disorders

Trinity team uncovers mutations linked with early onset dementia

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