Oncology News and Research

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Oncology, meaning bulk, mass, or tumor, and the suffix ''-logy'', meaning "study of") is a branch of medicine that deals with tumors (cancer). A medical professional who practices oncology is an ''oncologist''.

Pembrolizumab combination therapy improves survival in recurrent endometrial cancer patients

Previously, immature overall survival results of the NRG Oncology GY018 (NRG-GY018) trial suggested that the use of the immunotherapy drug pembrolizumab in combination with chemotherapy improved overall survival for patients with advanced stage or recurrent endometrial cancer when compared to chemotherapy alone.

29 May 2026

Gene test helps many breast cancer patients avoid chemotherapy

Many people with breast cancer can safely avoid chemotherapy with the use of a gene test, potentially sparing them unnecessary side effects without increasing the risk of the cancer returning, a large international clinical trial led by UCL has found.

29 May 2026

Teclistamab delivers deeper responses in relapsed myeloma patients

Patients with relapsed multiple myeloma treated with the immunotherapy teclistamab lived significantly longer and remained in remission far longer than those receiving standard therapies, according to results from a major international phase 3 clinical trial published in The New England Journal of Medicine and presented at the 2026 American Society of Clinical Oncology (ASCO) Annual Meeting.

29 May 2026

Targeted therapy sunvozertinib outperforms standard chemotherapy in advanced lung cancer trial

The targeted therapy sunvozertinib was more effective than standard platinum-based chemotherapy as a first-line treatment for patients with advanced non-small cell lung cancer (NSCLC) driven by EGFR exon 20 insertion mutations (EGFR exon20ins), according to new research from The University of Texas MD Anderson Cancer Center.

29 May 2026

AI-powered atlas maps immune structures across multiple cancer types

In a new study published today in Science, researchers from The University of Texas MD Anderson Cancer Center developed a spatial atlas of specialized immune structures, called tertiary lymphoid structures (TLSs), across multiple cancer types.

28 May 2026

AI model tracks child maturity patterns through routine ECG data

A new study from Wake Forest University School of Medicine suggests a routine heart test – an electrocardiogram (ECG) – may offer researchers a new way to measure biological development in children and adolescents.

28 May 2026

Degrading mutant KRAS protein induces greater lung cancer regression

KRAS is one of the oncogenes most frequently altered in cancer, mutated in approximately one-third of lung adenocarcinomas.

27 May 2026

NCCN launches a free service for updates on clinical cancer guidelines

The National Comprehensive Cancer Network (NCCN)-the nonprofit alliance of leading cancer centers responsible for essential NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) that providers rely on worldwide-has launched a new, free service.

27 May 2026

Lung cancer cells change identity to resist medical treatments

Cancer scientists have discovered that lung cancer cells can change their identity to resist treatment.

27 May 2026

Special yoga intervention helps cancer survivors manage psychological side effects

University of Rochester Medicine is in the spotlight at a national meeting for a new discovery in integrative oncology: A special yoga intervention, the study shows, goes a step further than other side-effect therapies to improve four domains of physical and psychological side effects that most patients experience, including lifting mood and easing anxiety.

26 May 2026

New AI model predicts cancer treatment responses from mutations

Researchers at University of California San Diego have developed a new artificial intelligence (AI) model that can translate a tumor's complex genetic profile into predictions about how that cancer may respond to treatment.

26 May 2026

Roswell Park scientists present five key cancer studies at clinical meeting

The research findings of experts from Roswell Park Comprehensive Cancer Center will be featured during the American Society of Clinical Oncology (ASCO) annual meeting May 29 to June 2 at McCormick Place in Chicago.

25 May 2026

Metabolic reprogramming helps tumor cells adapt and evade the human immune system

A newly published review article highlights the critical role of fatty acid metabolism in shaping the tumor microenvironment and influencing cancer progression, offering fresh perspectives for the development of more effective therapies.

25 May 2026

DNA methylation variability may improve precision cancer treatment strategies

A new review article brings attention to the critical role of DNA methylation heterogeneity in shaping the tumor microenvironment, highlighting its growing importance in understanding cancer progression and advancing more precise treatment strategies.

24 May 2026

DNA repair gene variations reveal evolutionary roots of cancer susceptibility

A new review highlights how human evolution has shaped the presence of pathogenic variations in DNA damage repair (DDR) genes, offering a new perspective on why modern populations face increased cancer susceptibility.

24 May 2026

Extrachromosomal circular DNA shows promise for precision disease diagnostics

A new scientific focus on extrachromosomal circular DNA (eccDNA) is opening transformative possibilities for disease detection, monitoring, and personalized medicine.

24 May 2026

AI-engineered p53 superproteins may reshape future cancer therapies

The Oncodarwinian Hypothesis (OdH) proposes a paradigm shift: cancer is not merely a disease but a potential macro‑immunoadaptive response – a self‑replicating algorithm that can be reprogrammed via AI‑based 3D printed p53 superproteins.

22 May 2026

New biomarker predicts therapy response for hard-to-treat childhood cancers

A study by researchers at the University of Birmingham has identified a new biomarker for response to a specific cancer therapy, treating children with Ewing Sarcoma and other tumor types.

22 May 2026

Explainable AI could make breast cancer drug predictions safer and clearer

AI-driven genomic analysis could help researchers identify existing drugs that may be repurposed for subtype-specific breast cancer treatment. The review proposes an interpretability-driven framework that links multi-omics data, mechanistic validation, and clinical translation to make AI predictions more transparent and clinically useful.

22 May 2026

New discovery maps how mutant colorectal tumors adapt to KRAS inhibitors

A new preclinical study led by researchers at The University of Texas MD Anderson Cancer Center and Weill Cornell Medicine has uncovered genetic and cell-state adaptive mechanisms that drive resistance to KRAS inhibitors in patients with KRAS-mutant colorectal cancer.

22 May 2026