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Age-related macular degeneration reported to confer higher risk of severe SARS-CoV-2 infection

Recent evidence has emerged to suggest that age-related macular degeneration (AMD) is a clinical risk factor for increased risk for infection and mortality.

3 Jan 2023

Viral short RNAs detected in SARS-CoV-2 RNA transcriptome

Researchers analyzed the ribonucleic acid (RNA) transcriptome associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-CoV-1-infected human cells.

3 Jan 2023

'Epigenetic fingerprints' of prenatal alcohol exposure could be biomarkers to detect developmental disorders

Alcohol exposure in early pregnancy can change gene function during the tightly regulated embryonic development, and consequently cause developmental disorders - especially neurodevelopmental disorders.

3 Jan 2023

What is the impact of COVID-19 on the human genetic architecture?

Researchers recently described the second update on the study of human genetic architecture with respect to the effect of coronavirus disease 2019 (COVID-19).

3 Jan 2023

Deep learning tool identifies mosaic mutations that cause disease

Genetic mutations cause hundreds of unsolved and untreatable disorders. Among them, DNA mutations in a small percentage of cells, called mosaic mutations, are extremely difficult to detect because they exist in a tiny percentage of the cells.

2 Jan 2023

BA.4/BA.5 mutations reduced responsiveness of epitope-specific T cells with original mRNA vaccine

A new study in the journal Viruses examines the phenomenon of breakthrough infections due to the evasion of T-cell immunity by the Omicron BA.4/BA.5 subvariants, showing this to be due to spike gene mutations.

2 Jan 2023

New method records gene activity patterns and presence of proteins across tissues

A new method can illuminate the identities and activities of cells throughout an organ or a tumor at unprecedented resolution, according to a study co-led by researchers at Weill Cornell Medicine, NewYork-Presbyterian and the New York Genome Center.

2 Jan 2023

Enzyme that defends human cells against viruses may be a potential target for future cancer treatments

An enzyme that defends human cells against viruses can help drive cancer evolution towards greater malignancy by causing myriad mutations in cancer cells, according to a study led by investigators at Weill Cornell Medicine.

28 Dec 2022

A genome-based comparison of SARS-CoV-2 XBB recombinant and its parental lineage

In a recent study posted to the bioRxiv* preprint server, researchers in Italy performed a genome-based comparison of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) XBB recombinant with its parental lineages.

27 Dec 2022

New software accurately infers continental ancestry from tumor DNA and RNA

Could knowing where your ancestors came from be the key to better cancer treatments? Maybe, but where would that key fit? How can we trace cancer's ancestral roots to modern-day solutions?

27 Dec 2022

UTSW researchers identify molecular function of 87 inherited genetic variants linked to prostate cancer

UT Southwestern researchers have identified the molecular function of 87 inherited genetic variants that affect the risk of prostate cancer, and the majority appear to control the activity of genes located far away from the risk variants themselves.

23 Dec 2022

Scientists study OAS–RNase L errors and COVID-19-associated multisystem inflammatory syndrome in children

Researchers assessed the inborn abnormalities of 2′-5′-oligoadenylate synthetase (OAS)-ribonuclease L (RNASEL) noted in coronavirus disease 2019 (COVID-19)-associated multisystem inflammatory syndrome in children (MIS-C).

23 Dec 2022

Cellular models based on reprogrammed human cells could boost development of efficient therapies

Studies on diseases that affect the human brain are usually based on animal models which cannot reproduce the complexity of human neuropathies.

22 Dec 2022

Decade-long search in one-celled, fresh water dwelling organism solves puzzle involved in gene regulation

After an intrepid, decade-long search, Johns Hopkins Medicine scientists say they have found a new role for a pair of enzymes that regulate genome function and, when missing or mutated, are linked to diseases such as brain tumors, blood cancers and Kleefstra syndrome - a rare genetic, neurocognitive disorder.

22 Dec 2022

Genome News and Research

Age-related macular degeneration reported to confer higher risk of severe SARS-CoV-2 infection

Viral short RNAs detected in SARS-CoV-2 RNA transcriptome

'Epigenetic fingerprints' of prenatal alcohol exposure could be biomarkers to detect developmental disorders

What is the impact of COVID-19 on the human genetic architecture?

Deep learning tool identifies mosaic mutations that cause disease

BA.4/BA.5 mutations reduced responsiveness of epitope-specific T cells with original mRNA vaccine

New method records gene activity patterns and presence of proteins across tissues

Enzyme that defends human cells against viruses may be a potential target for future cancer treatments

A genome-based comparison of SARS-CoV-2 XBB recombinant and its parental lineage

New software accurately infers continental ancestry from tumor DNA and RNA

UTSW researchers identify molecular function of 87 inherited genetic variants linked to prostate cancer

Scientists study OAS–RNase L errors and COVID-19-associated multisystem inflammatory syndrome in children

Cellular models based on reprogrammed human cells could boost development of efficient therapies

Decade-long search in one-celled, fresh water dwelling organism solves puzzle involved in gene regulation

PTSD, TBI, and a genetic variant show strong links with Alzheimer's Disease and related dementias

Study increases understanding of the genetic architecture of dementia risk in African ancestry populations

Radiation damage to mature sperm cannot be repaired and is instead passed on to the offspring

Comprehensive lung cell atlas offers insights into an unexpected immune niche in the airways

Huge multi-omic data analysis deciphers colorectal cancer genetics

Findings on the origins of the SARS-CoV-2 variant Omicron retracted

The art of CRISPR: The power and promise of gene editing eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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