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Combination therapy sets new survival standard for advanced biliary tract cancer

In a follow-up analysis to the pivotal TOPAZ-1 study, which established the combination therapy of durvalumab (an immunotherapy drug) plus gemcitabine and cisplatin (GemCis, chemotherapy drugs) as the first-line treatment for people with advanced biliary tract cancer (aBTC), researchers have shown that after three years more than twice as many study participants treated with durvalumab plus GemCis had survived compared to those treated with a placebo plus GemCis.

10 Jul 2025

Chan Zuckerberg initiative unveils AI model to decode cellular behavior

Today, the Chan Zuckerberg Initiative (CZI) announced its latest AI model aimed at helping researchers better understand how cells behave by focusing on the key networks that control cell behavior, making complex biological problems, like cancer, easier to solve.

10 Jul 2025

Psilocybin may have potential to revolutionize anti-aging therapies

As revenues from the anti-aging market-- riddled with hope and thousands of supplements–– surged past $500 million last year, Emory University researchers identified a compound that actively delays aging in cells and organisms.

9 Jul 2025

Virginia Tech researchers explore creatine therapy for brain health

Creatine is popularly known as a muscle-building supplement, but its influence on human muscle function can be a matter of life or death.

9 Jul 2025

Exercise improves cancer outcomes by shaping the gut microbiome

A new study from the University of Pittsburgh shows for the first time how exercise improves cancer outcomes and enhances response to immunotherapy in mice by reshaping the gut microbiome.

9 Jul 2025

FDA-approved drugs can help enhance the safety of nanomedicines

An international study led by researchers at the University of Colorado Anschutz Medical Campus has identified a promising strategy to enhance the safety of nanomedicines, advanced therapies often used in cancer and vaccine treatments, by using drugs already approved by the FDA for unrelated conditions.

9 Jul 2025

Experimental treatment reverses paralysis in child with rare mitochondrial disease

The value of a recent biochemical discovery can be seen in the case of an 8-year-old boy. In August 2023 he was able to play typical sports, but by November he needed a wheelchair because of a rare disease that caused worsening paralysis.

9 Jul 2025

Innovative genome editing approach could be the key to lifelong effective weight management

Weight-loss drugs have surged in popularity, promising rapid results with regular injections. Now, researchers from Japan report a way for the body to make its own weight-loss drugs, doing away with injections in favor of a one-time treatment.

9 Jul 2025

New study identifies four distinct autism subtypes with unique genetic signatures

Autism is classified as a 'spectrum' for a reason: Each case is different. Scientists have struggled to parse through the many ways autism can manifest, much less to link these varying observable traits (called phenotypes) to underlying genetics.

9 Jul 2025

New study identifies factors linked to successful weight loss using GLP-1RAs

A study in Diabetes, Obesity and Metabolism has identified certain characteristics that might influence people's weight loss after taking prescription drugs called glucagon-like peptide-1 receptor agonists (GLP-1RAs), such as semaglutide (sold under the brand names Ozempic and Wegovy).

9 Jul 2025

Nanohydrogel formulation of 5-fluorouracil shows promise for skin cancer therapy

Announcing a new article publication for BIO Integration journal. The pyrimidine analog 5-flurouracil (5-FU) is effective against solid tumors.

9 Jul 2025

Genetically modified herpes virus shows promise against advanced melanoma

The herpes simplex virus type 1 (HSV-1), which affects almost two-thirds of the world's population and is generally associated with oral herpes, may cause painful cold sores or fever blisters around the mouth.

9 Jul 2025

New TB drugs show promise with fewer side effects than linezolid

The drugs, sutezolid and delpazolid, have demonstrated strong antimicrobial activity and a notably better safety profile compared to linezolid, with potential to replace this current cornerstone in the treatment of drug-resistant TB.

8 Jul 2025

New small molecule shows promise against cutaneous HPV infections

Human papillomaviruses, or HPVs, can cause dangerous infections in the skin and mucous membranes and may lead to cancer.

8 Jul 2025

AI chatbots are not safe replacements for therapists, research says

Should AI chatbots replace your therapist? New research says "no." The new study exposes the dangerous flaws in using artificial intelligence (AI) chatbots for mental health support. For the first time, the researchers evaluated these AI systems against clinical standards for therapists.

8 Jul 2025

New funding brings personalized CRISPR cures closer to children with rare diseases

Personalized CRISPR cures for children born with rare genetic diseases are now a step closer to being more widely available.

8 Jul 2025

Tiny nanobody shows big promise in fighting Nipah and Hendra viruses

Researchers have discovered a strategy to neutralize two highly lethal viruses for which there is currently no approved vaccine or cure.

8 Jul 2025

Brain stimulation and coaching help older adults increase physical activity

A study published in The Journals of Gerontology: Series A reports that a novel combination of brain stimulation and personalized coaching significantly increased physical activity in older adults and held steady for months.

8 Jul 2025

Corticosteroids may reduce effectiveness of immunotherapy in lung cancer

Corticosteroids, a commonly prescribed medication to alleviate cancer-related symptoms for non-small cell lung cancer patients treated with immunotherapy, are the main reason certain immunotherapies may fail in treating the disease, according to new research by Keck Medicine of USC.

7 Jul 2025

New combination therapy inhibits tumor growth and blocks drug-induced resistance in ovarian cancer

A pairing of two experimental drugs inhibits tumor growth and blocks drug-induced resistance in ovarian cancer, according to a preclinical study led by Weill Cornell Medicine investigators.

7 Jul 2025

Therapy News and Research

Combination therapy sets new survival standard for advanced biliary tract cancer

Chan Zuckerberg initiative unveils AI model to decode cellular behavior

Psilocybin may have potential to revolutionize anti-aging therapies

Virginia Tech researchers explore creatine therapy for brain health

Exercise improves cancer outcomes by shaping the gut microbiome

FDA-approved drugs can help enhance the safety of nanomedicines

Experimental treatment reverses paralysis in child with rare mitochondrial disease

Innovative genome editing approach could be the key to lifelong effective weight management

New study identifies four distinct autism subtypes with unique genetic signatures

New study identifies factors linked to successful weight loss using GLP-1RAs

Nanohydrogel formulation of 5-fluorouracil shows promise for skin cancer therapy

Genetically modified herpes virus shows promise against advanced melanoma

New TB drugs show promise with fewer side effects than linezolid

New small molecule shows promise against cutaneous HPV infections

AI chatbots are not safe replacements for therapists, research says

New funding brings personalized CRISPR cures closer to children with rare diseases

Tiny nanobody shows big promise in fighting Nipah and Hendra viruses

Brain stimulation and coaching help older adults increase physical activity

Corticosteroids may reduce effectiveness of immunotherapy in lung cancer

New combination therapy inhibits tumor growth and blocks drug-induced resistance in ovarian cancer

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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