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Researchers uncover new clues to why BRCA1 mutations cause breast and ovarian cancer

The human body holds many mysteries, and function of the BRCA1 gene is among them. Women who inherit a faulty copy of BRCA1 have up to a 65 percent chance to develop breast cancer by age 70. They also have up to a 39 percent chance to develop ovarian cancer.

19 Jul 2017

Two cell types partner to protect pancreatic tumors from immune attack

Two cell types work together to protect pancreatic tumors from destruction by the immune system. But, blocking this partnership may restore the system's ability to attack these same tumor cells.

19 Jul 2017

Scientists manage to permeate living cells with small antibodies

Scientists at the Technische Universität Darmstadt, Ludwig Maximilians University Munich and the Leibniz Institute for Molecular Pharmacology have managed to introduce tiny antibodies into living cells. The researchers now report on the synthesis and applications for these nanobodies in "Nature Chemistry".

19 Jul 2017

Titanium dioxide nanoparticles can intensify inflammatory reaction in patients with colitis

Titanium dioxide, one of the most-produced nanoparticles worldwide, is being used increasingly in foodstuffs.

19 Jul 2017

Researchers identify new way to increase immune response against cancer and infections

An international research team led by Université de Montréal medical professor Christopher Rudd, director of research in immunology and cell therapy at Maisonneuve-Rosemont Hospital Research Centre, has identified a key new mechanism that regulates the ability of T-cells of the immune system to react against foreign antigens and cancer.

19 Jul 2017

Unique 'Golden Hour' study details ultra-early immune response to trauma

Scientists from the University of Birmingham are carrying out pioneering research as part of a major £10 million study aimed at improving outcomes for patients who have suffered a traumatic injury.

19 Jul 2017

Research shows how dietary essential fatty acids can help treat Alzheimer’s, other diseases

Understanding how dietary essential fatty acids work may lead to effective treatments for diseases and conditions such as stroke, Alzheimer's disease, age-related macular degeneration, Parkinson's disease and other retinal and neurodegenerative diseases.

18 Jul 2017

Timing of food consumption affects circadian rhythms and body weight

A new high-precision feeding system for lab mice reinforces the idea that the time of day food is eaten is more critical to weight loss than the amount of calories ingested.

18 Jul 2017

Study shows how cells feel their way through the surroundings

Cells push out tiny feelers to probe their physical surroundings, but how much can these tiny sensors really discover? A new study led by Princeton University researchers and colleagues finds that the typical cell's environment is highly varied in the stiffness or flexibility of the surrounding tissue, and that to gain a meaningful amount of information about its surroundings, the cell must move around and change shape.

18 Jul 2017

Researchers discover gene mutations that worsen respiratory infections among children

Researchers funded by the Swiss National Science Foundation have discovered mutations that worsen respiratory infections among children. Their study explains the mechanism involved.

18 Jul 2017

Developing software for cell and gene therapy supply chain tracking

The first thing is, to always remember that we're dealing with a living drug, cells, which are very sensitive to environmental conditions, such as temperature and humidity etc. All of those things can impact on the viability of the drug and its effectiveness.

18 Jul 2017

Low-dose anxiolytics can ameliorate social disadvantage related to trait anxiety

Psychologists speak of anxiety in two forms: "state" anxiety, which refers to anxiety arising from a particular situation; and "trait" anxiety, which refers to anxiety as part of a person's overall personality.

18 Jul 2017

Study provides insights into intergenerational inheritance of epigenetic information

We are more than the sum of our genes. Epigenetic mechanisms modulated by environmental cues such as diet, disease or our lifestyle take a major role in regulating the DNA by switching genes on and off.

18 Jul 2017

Researchers discover reason for chemoresistance in small cell lung cancer

Approximately one year after successful treatment with cytotoxic chemotherapy and radiotherapy, patients with advanced Small Cell Lung Cancer (SCLC), which primarily affects heavy smokers, generally relapse with recurrence of tumours that are resistant to further chemotherapy.

18 Jul 2017

Researcher models heart attack in petri dishes to gain insights into cardiac diseases

In petri dishes in her campus laboratory at New Jersey Institute of Technology, Alice Lee is developing colonies of cardiac cells, formed into chambers, that pump and contract like a human heart.

18 Jul 2017

FDA approves first extended adjuvant therapy to lower risk of breast cancer recurrence

The U.S. Food and Drug Administration today approved Nerlynx (neratinib) for the extended adjuvant treatment of early-stage, HER2-positive breast cancer.

18 Jul 2017

New analysis compares emerging algorithms that look for cancer mutations

Sanford Burnham Prebys Medical Discovery Institute has undertaken the first-ever comparative analysis of a newly emerging category of algorithms that mine genetic information in cancer databases by focusing on internal gene structure (subgene resolution algorithms), in contrast to classical approaches that focus on genes treated as single units.

17 Jul 2017

NIH researchers show how investigational drug works against rare, fatal genetic disease

Scientists have demonstrated how an investigational drug works against a rare, fatal genetic disease, Niemann-Pick type C1 (NPC1).

17 Jul 2017

Study identifies new gene involved in Fanconi anemia

Researchers from the group led by UAB Chair Professor Dr Jordi Surrallés at the Hospital de la Santa Creu i Sant Pau, Barcelona, the Universitat Autònoma de Barcelona and the CIBER of Rare Diseases participated in a study which has led to the identification of a new gene involved in Fanconi anemia, a rare genetic disease.

17 Jul 2017

Mutations arising after conception may play vital role in autism

A study of nearly 6,000 families, combining three genetic sequencing technologies, finds that mutations that occur after conception play an important role in autism.

17 Jul 2017

B Cell News and Research

Researchers uncover new clues to why BRCA1 mutations cause breast and ovarian cancer

Two cell types partner to protect pancreatic tumors from immune attack

Scientists manage to permeate living cells with small antibodies

Titanium dioxide nanoparticles can intensify inflammatory reaction in patients with colitis

Researchers identify new way to increase immune response against cancer and infections

Unique 'Golden Hour' study details ultra-early immune response to trauma

Research shows how dietary essential fatty acids can help treat Alzheimer’s, other diseases

Timing of food consumption affects circadian rhythms and body weight

Study shows how cells feel their way through the surroundings

Researchers discover gene mutations that worsen respiratory infections among children

Developing software for cell and gene therapy supply chain tracking

Low-dose anxiolytics can ameliorate social disadvantage related to trait anxiety

Study provides insights into intergenerational inheritance of epigenetic information

Researchers discover reason for chemoresistance in small cell lung cancer

Researcher models heart attack in petri dishes to gain insights into cardiac diseases

FDA approves first extended adjuvant therapy to lower risk of breast cancer recurrence

New analysis compares emerging algorithms that look for cancer mutations

NIH researchers show how investigational drug works against rare, fatal genetic disease

Study identifies new gene involved in Fanconi anemia

Mutations arising after conception may play vital role in autism

Industry focus eBook - Cell and gene therapy (2nd edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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