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Skin biopsy can aid in early identification and differential diagnosis of Parkinson's disease

The diagnosis of Parkinson's disease (PD) is currently based on consensus clinical criteria. A novel study reported in the Journal of Parkinson's Disease has found that the presence of neuronal deposits of the biomarker phosphorylated alpha-synuclein (p-syn) in the brain and the skin of patients with PD distinguishes them from individuals with symptoms of parkinsonism due to the accumulation of another protein, tau.

15 Mar 2022

Temporary increase in dopamine levels initiates sleep state transitions

Historically, the neurological mechanisms underlying sleep-cycle generation have been elusive. But now, researchers from Japan have uncovered new information about how the brain transitions from one sleep state to another.

15 Mar 2022

Using mRNA to introduce gene editor into human muscle stem cells

Mutations that lead to muscle atrophy can be repaired with the gene editor CRISPR-Cas9. A team led by ECRC researcher Helena Escobar has now introduced the tool into human muscle stem cells for the first time using mRNA, thus discovering a method suitable for therapeutic applications.

14 Mar 2022

New smartphone app can calculate users’ genetic risk for coronary artery disease

A Scripps Research team developed a smartphone app that can calculate users' genetic risk for coronary artery disease (CAD) - and found that users at high risk sought out appropriate medication after using the app.

14 Mar 2022

New Phase 1 clinical trial of mRNA HIV vaccine enrolls first participant

The first 12 study participants have been enrolled in a new Phase 1 clinical trial using the messenger ribonucleic acid (mRNA) vaccine technology developed by Moderna.

14 Mar 2022

Malaria drug could help treat chemotherapy-resistant head and neck cancers

A new study suggests that the malaria drug hydroxychloroquine inhibits pathways that drive resistance to the chemotherapy agent cisplatin in head and neck cancers and restores tumor-killing effects of cisplatin in animal models.

14 Mar 2022

Insight into oligodendrocytes in the brain could shed light on the causes of neurodegenerative diseases

New research may help scientists locate immature cells in the central nervous system that could shed light on the causes of neurodegenerative diseases like multiple sclerosis - and autoimmune disease that affects the brain and nervous system - and allow for the development of better therapeutic treatments.

12 Mar 2022

Exercise counters inflammation that leads to diabetes, depression after COVID-19

While no medically recognized treatment exists for Long COVID, exercise may break the vicious cycle of inflammation that can lead to developing diabetes and depression months after a person recovers from the virus.

11 Mar 2022

Cellular therapy offers promise for patients with Duchenne muscular dystrophy, trial shows

A clinical trial at UC Davis Health and six other sites showed that a cellular therapy offers promise for patients with late-stage Duchenne muscular dystrophy (DMD), a rare genetic disorder causing muscle loss and physical impairments in young people.

10 Mar 2022

Cedars-Sinai scientists identify potential new therapy for COVID-19

Investigators at Cedars-Sinai have identified a potential new therapy for COVID-19: a biologic substance created by reengineered human skin cells.

9 Mar 2022

Rising global temperatures likely to increase the health burden from hyponatremia

Global warming is likely to increase the number of people requiring hospitalization due to critically low sodium levels in the blood, a condition known as hyponatremia.

8 Mar 2022

Lab-grown pig heart tissue could open new avenues for the study of heart regeneration

A new way to replicate what happens inside the heart after cardiac arrest could open new avenues for the study of heart regeneration whilst reducing the use of live animals in research, according to a study from the University of Surrey and King’s College London.

8 Mar 2022

Glucocorticoid steroids improve muscle performance through distinct, sex-specific molecular pathways

Glucocorticoid steroids improved muscle performance through distinct, sex-specific molecular mechanisms in mice, according to a Northwestern Medicine study published in the Journal of Clinical Investigation.

7 Mar 2022

Slowing down the DNA replication speed increases cell reprogramming efficiency

Adult cells in our body can only give rise to the same cell type. For example, a skin cell cannot give rise to a muscle cell but to skin cells only.

7 Mar 2022

NETosis in COVID-19 and MIS-C

A new study investigates the role played by neutrophil extracellular traps formation and degradation in COVID-19.

7 Mar 2022

GlyNAC supplementation can increase lifespan and improve multiple age-associated defects

Many people aspire to live longer, healthier lives. A researcher at Baylor College of Medicine, Dr. Rajagopal Sekhar, associate professor of medicine in the section of endocrinology, diabetes and metabolism, has been studying aging for the past 20 years to better understand its biological underpinnings and develop nutritional strategies to promote healthy aging.

7 Mar 2022

Reduced cognitive efficacy and cardiovascular changes in patients post-COVID-19 recovery

Researchers evaluated the association between cognitive impairment and clinical-functional variables in the coronavirus disease 2019 post-acute period.

7 Mar 2022

New DNA test can quickly and accurately identify a range of hard-to-diagnose genetic diseases

A new DNA test, developed by researchers at the Garvan Institute of Medical Research in Sydney and collaborators from Australia, UK and Israel, has been shown to identify a range of hard-to-diagnose neurological and neuromuscular genetic diseases quicker and more-accurately than existing tests.

4 Mar 2022

When teens blow off parents’ pleas to get vaccinated, the consequences can be deadly

Kennedy Stonum, a high school junior, deflected repeated entreaties from her father to please just get vaccinated against covid-19.

4 Mar 2022

Texas A&M team continues research on the potential cure for Menkes disease

A life-saving cure solution for Menkes Disease, a copper deficiency in young children, is at the center of a licensing agreement by the The Texas A&M University System, through the Intellectual Property and Commercialization office of Texas A&M AgriLife Research, and a California-based biopharmaceutical company, Engrail Therapeutics.

3 Mar 2022

Muscle News and Research

Skin biopsy can aid in early identification and differential diagnosis of Parkinson's disease

Temporary increase in dopamine levels initiates sleep state transitions

Using mRNA to introduce gene editor into human muscle stem cells

New smartphone app can calculate users’ genetic risk for coronary artery disease

New Phase 1 clinical trial of mRNA HIV vaccine enrolls first participant

Malaria drug could help treat chemotherapy-resistant head and neck cancers

Insight into oligodendrocytes in the brain could shed light on the causes of neurodegenerative diseases

Exercise counters inflammation that leads to diabetes, depression after COVID-19

Cellular therapy offers promise for patients with Duchenne muscular dystrophy, trial shows

Cedars-Sinai scientists identify potential new therapy for COVID-19

Rising global temperatures likely to increase the health burden from hyponatremia

Lab-grown pig heart tissue could open new avenues for the study of heart regeneration

Glucocorticoid steroids improve muscle performance through distinct, sex-specific molecular pathways

Slowing down the DNA replication speed increases cell reprogramming efficiency

NETosis in COVID-19 and MIS-C

GlyNAC supplementation can increase lifespan and improve multiple age-associated defects

Reduced cognitive efficacy and cardiovascular changes in patients post-COVID-19 recovery

New DNA test can quickly and accurately identify a range of hard-to-diagnose genetic diseases

When teens blow off parents’ pleas to get vaccinated, the consequences can be deadly

Texas A&M team continues research on the potential cure for Menkes disease

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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