Preclinical News and Research

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Researcher receives NIH award to explore effect of women's hormones on postpartum opioid relapse

When most people think of opioid addiction, they typically do not think of pregnant women. Unfortunately, however, the prevalence of opioid addiction during pregnancy has increased nearly 500% during the past 15 years.

8 Oct 2020

Multi-center Phase I study of anti-VISTA opens for patient enrollment

Dartmouth and Dartmouth-Hitchcock Norris Cotton Cancer Center will serve as one of the lead institutions for a new multi-center clinical trial of anti-VISTA, now open and recruiting for patient enrollment.

7 Oct 2020

A new technology to measure lens stiffness associated with presbyopia

A University of Houston biomedical researcher is developing new technology that will measure the stiffness of the lens in the eye, which is likely associated with presbyopia, or farsightedness, the inevitable and age-related loss of the ability to focus on nearby objects.

6 Oct 2020

Calibr's novel 'switchable' CAR-T cell therapy granted FDA's Fast Track designation

The U.S. Food and Drug Administration has granted Fast Track designation to a novel "switchable" CAR-T cell therapy developed by Calibr, a division of Scripps Research, in a move to accelerate the drug development and review process.

1 Oct 2020

Blood-based biomarker can overcome limitations of current verbal tests for concussion

There is an urgent need for objective markers for diagnosing concussion, or mild traumatic brain injury. The status of blood-based biomarker development and point-of-care testing are examined in a new Expert Panel Discussion published alongside the peer-reviewed Journal of Neurotrauma.

1 Oct 2020

New technology helps detect receptors that respond to odor of cigarette smoke

A recent publication in the Journal of Neuroscience by a group of researchers at the University of Kentucky looks at Encoding the Odor of Cigarette Smoke. Tim McClintock, a physiology professor at UK, says their work lays a foundation for two things.

1 Oct 2020

NIH awards grants for using bioengineered models to improve clinical trial design

Clinical Trials on a Chip researchers plan to build and test common and rare disease models to help improve the clinical trial process.

30 Sep 2020

Researchers report promising preclinical findings for a prototype of vascular graft

In a proof-of-concept study, North Carolina State University researchers reported promising preclinical findings for a prototype of a vascular graft designed as a replacement for a damaged or blocked coronary artery, which supplies blood to the heart.

30 Sep 2020

Blocking the self-destruction process of enzymes can mitigate age-related diseases

Stopping the cannibalistic behavior of a well-studied enzyme could be the key to new drugs to fight age-related diseases, according to a new study published online in Nature Cell Biology.

30 Sep 2020

Dietary oat bran can offset radiation-induced gut inflammation, study shows

Loved or hated, the humble oat could be the new superfood for cancer patients as international research shows a diet rich in fibre could significantly reduce radiation-induced gut inflammation.

29 Sep 2020

J&J's COVID-19 vaccine shows potent immune response in phase 2 human trial

A multicenter phase 1/2a randomized, double-blinded, placebo-controlled clinical trial has been conducted recently to evaluate the safety, reactogenicity, and immunogenicity of a non-replicating adenovirus-based vaccine, namely Ad26.COV2.S against severe acute respiratory coronavirus 2 (SARS-CoV-2) infection.

28 Sep 2020

New mechanism that prevents hair loss identified

A team of researchers from Cologne and Helsinki has discovered a mechanism that prevents hair loss: hair follicle stem cells, essential for hair to regrow, can prolong their life by switching their metabolic state in response to low oxygen concentration in the tissue.

28 Sep 2020

Targeted therapy found to be effective at shrinking tumors in patients with nonsmall-cell lung cancer

An international team of researchers has found that selpercatinib, a drug that precisely targets cancers driven by mutations or alterations in the gene RET, was effective at shrinking tumours in patients with nonsmall cell lung cancer (NSCLC), with a majority of patients living for more than a year without disease progression.

28 Sep 2020

Seniors the optimal target for SARS-CoV-2 vaccination

ith several vaccines already in stage 3 clinical trials, a study by University of Warwick researchers and published on the preprint server medRxiv in September 2020 discusses the use of computer modeling techniques in order to achieve optimal vaccine coverage.

28 Sep 2020

Researchers elucidate the impact of genetic mutations in cocaine addiction

Cocaine addiction is a chronic disorder with a high rate of relapse for which no effective treatment is currently available.

26 Sep 2020

AXT add Vieworks bio-imaging solutions to their preclinical imaging portfolio

AXT is excited to add the Vieworks range of bio-imaging systems to their preclinical imaging product portfolio. Their in-vivo imaging systems provide outstanding performance in bioluminescent and fluorescent imaging and represents excellent value.

From AXT Pty Ltd 26 Sep 2020

New strategic collaboration to accelerate treatments for unmet medical needs in oncology

The University of Texas MD Anderson Cancer Center and Taiho Pharmaceutical Co., Ltd., today announced a three-year strategic collaboration to accelerate the development of treatments for significant unmet medical needs in oncology, including patients with brain metastases and those with cancers refractory to available therapies.

25 Sep 2020

Preclinical News and Research

Researcher receives NIH award to explore effect of women's hormones on postpartum opioid relapse

Multi-center Phase I study of anti-VISTA opens for patient enrollment

A new technology to measure lens stiffness associated with presbyopia

Calibr's novel 'switchable' CAR-T cell therapy granted FDA's Fast Track designation

Blood-based biomarker can overcome limitations of current verbal tests for concussion

New technology helps detect receptors that respond to odor of cigarette smoke

NIH awards grants for using bioengineered models to improve clinical trial design

Researchers report promising preclinical findings for a prototype of vascular graft

Blocking the self-destruction process of enzymes can mitigate age-related diseases

Dietary oat bran can offset radiation-induced gut inflammation, study shows

J&J's COVID-19 vaccine shows potent immune response in phase 2 human trial

New mechanism that prevents hair loss identified

Targeted therapy found to be effective at shrinking tumors in patients with nonsmall-cell lung cancer

Seniors the optimal target for SARS-CoV-2 vaccination

Researchers elucidate the impact of genetic mutations in cocaine addiction

AXT add Vieworks bio-imaging solutions to their preclinical imaging portfolio

New strategic collaboration to accelerate treatments for unmet medical needs in oncology

Fourth Phase 3 clinical trial evaluating COVID-19 vaccine begins in the U.S.

Light therapy is safe and can benefit patients with TBI, shows study

New book sheds light on addiction to psychoactive drugs

New Approach Methodologies, the 3Rs and Multimodal Imaging in Preclinical Research - eBook eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics