Proliferation News and Research

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High CIP2A may guide TKI choice for chronic phase CML

Treatment with a second-generation tyrosine kinase inhibitor prevents progression to blast crisis in chronic myeloid leukaemia patients with high levels of cancerous inhibitor of PP2A, research suggests.

29 May 2015

First European approval of drug to treat genetic kidney disease ADPKD

Otsuka Pharmaceutical Co., Ltd. announced that the European Commission has granted marketing authorisation for JINARC® (tolvaptan) for the treatment of ADPKD in adults who have chronic kidney disease (CKD) stage one to three at initiation of treatment with evidence of rapidly progressing disease

29 May 2015

Green tea components may help prevent prostate cancer development in at-risk men

Prostate cancer is the second most common type of cancer in men and is predicted to result in an estimated 220,00 cases in the United States in 2015. In recent years, an emphasis has been placed on chemoprevention - the use of agents to prevent the development or progression of prostate cancer.

29 May 2015

Researchers suggest new target for treating BRAF inhibitor-resistant melanoma tumors

A new collaborative study led by researchers at Sanford-Burnham Medical Research Institute, published today in Cell Reports, provides new insight into the molecular changes that lead to resistance to a commonly prescribed group of drugs called BRAF inhibitors.

28 May 2015

SurgiQuest receives FDA clearance for AirSeal System for Transanal Endoscopic Surgery

SurgiQuest, Inc., a leading provider of innovative access technologies for minimally invasive surgery (MIS), today announced that its AirSeal System recently received 510(k) Clearance from the FDA for Transanal Endoscopic Surgery (TES).

28 May 2015

Progression of different types of breast cancer influenced differently by tumor microenvironment

Our environment can have a major impact on how we develop, and it turns out it's no different for cancer cells. In work published today in Neoplasia, a team of researchers led by Associate Professor Mikala Egeblad at Cold Spring Harbor Laboratory found that two different mouse models of breast cancer progressed differently based on characteristics of the tumor microenvironment - the area of tissue in which the tumor is embedded.

28 May 2015

Nanoparticle-based therapy effective in treating mice with multiple myeloma

Researchers have designed a nanoparticle-based therapy that is effective in treating mice with multiple myeloma, a cancer of immune cells in the bone marrow.

21 May 2015

Research may offer new targets for diagnosing, treating advanced prostate cancer

Researchers with the Indiana University School of Medicine have identified a molecule that promotes metastasis of advanced prostate cancer to the bone, an incurable condition that significantly decreases quality of life.

20 May 2015

Researcher uses short pulsed electric fields to preserve milk

Even though much of the population in developing countries is involved in agriculture, food security is virtually out of reach. Often the only resort is to purchase a cow, buffalo, or sheep, to provide a steady supply of fresh milk, a nutritious staple of a daily diet. But how to preserve it safely? Refrigeration and boiling are costly -- and often impossible due to sporadic electricity.

20 May 2015

Risk factors predict geographic atrophy after anti-VEGF treatment of RAP

Researchers have found three factors that could identify which patients with retinal angiomatous proliferation receiving anti-vascular endothelial growth factor treatment are likely to develop geographic atrophy.

19 May 2015

New microfluidic chip can capture rare clusters of circulating tumor cells

Researchers have developed a microfluidic chip that can capture rare clusters of circulating tumor cells, which could yield important new insights into how cancer spreads. The work was funded by the National Institute of Biomedical Imaging and Bioengineering, part of the National Institutes of Health.

19 May 2015

OSU researchers find promising approach to treating epithelial cancer

Researchers at Oregon State University are pursuing a new concept in treatment of epithelial cancer, especially head and neck cancer, by using two promising "analogs" of an old compound that was once studied as a potent anti-tumor agent, but long ago abandoned because it was too toxic.

19 May 2015

E-cigarette liquid flavors may alter key cellular functions in lung tissue

Certain flavorings used in electronic cigarette liquid may alter important cellular functions in lung tissue, according to new research presented at the 2015 American Thoracic Society International Conference.

18 May 2015

Two physicians examine heart disease through a literary lens

Heart disease has topped mortality charts as the No. 1 killer of men and women for many decades, but a novel analysis of American literary fiction by two physicians finds the disorder’s presence in great novels has remained relatively modest.

12 May 2015

New study explores use of mobility devices among older adults in U.S.

America's population of senior citizens is growing, and with it, a reliance on canes, wheelchairs and scooters. The use of walking aids has increased by 50 percent in the past decade, according to a new study, and should continue to increase as the number of seniors is expected to double by 2050.

12 May 2015

Researchers identify three genes involved in choroid plexus carcinoma

Researchers have identified three genes that play a pivotal role in the brain tumor choroid plexus carcinoma (CPC), a discovery that lays the groundwork for more effective treatment of this rare, often fatal cancer. St. Jude Children's Research Hospital scientists led the study, which appears today in the journal Cancer Cell.

12 May 2015

Study: Disrupting cancer pathway could extend benefits of new immunity-boosting drugs

Understanding how to overrule a signaling pathway that can cause treatments to fail in metastatic melanoma patients should help physicians extend the benefits of recently approved immunity-boosting drugs known as checkpoint inhibitors to more patients.

12 May 2015

New study finds link between father's age at birth and child's risk of blood cancer as an adult

A new study links a father's age at birth to the risk that his child will develop blood and immune system cancers as an adult, particularly for only children. The study, which appears in the American Journal of Epidemiology, found no association between having an older mother and these cancers.

12 May 2015

Scientists identify gene that causes hereditary hypertension and brachydactyly type E

Individuals with this altered gene have hereditary hypertension (high blood pressure) and at the same time a skeletal malformation called brachydactyly type E, which is characterized by unusually short fingers and toes. The effect on blood pressure is so serious that -- if left untreated -- it most often leads to death before age fifty.

11 May 2015

Walnut-enriched diet may slow colorectal tumor growth

A new animal study from Beth Israel Deaconess Medical Center, Harvard Medical School, led by Dr. Christos Mantzoros, indicates that a diet containing walnuts may slow colorectal tumor growth by causing beneficial changes in cancer genes.

11 May 2015

Proliferation News and Research

High CIP2A may guide TKI choice for chronic phase CML

First European approval of drug to treat genetic kidney disease ADPKD

Green tea components may help prevent prostate cancer development in at-risk men

Researchers suggest new target for treating BRAF inhibitor-resistant melanoma tumors

SurgiQuest receives FDA clearance for AirSeal System for Transanal Endoscopic Surgery

Progression of different types of breast cancer influenced differently by tumor microenvironment

Nanoparticle-based therapy effective in treating mice with multiple myeloma

Research may offer new targets for diagnosing, treating advanced prostate cancer

Researcher uses short pulsed electric fields to preserve milk

Risk factors predict geographic atrophy after anti-VEGF treatment of RAP

New microfluidic chip can capture rare clusters of circulating tumor cells

OSU researchers find promising approach to treating epithelial cancer

E-cigarette liquid flavors may alter key cellular functions in lung tissue

Two physicians examine heart disease through a literary lens

New study explores use of mobility devices among older adults in U.S.

Researchers identify three genes involved in choroid plexus carcinoma

Study: Disrupting cancer pathway could extend benefits of new immunity-boosting drugs

New study finds link between father's age at birth and child's risk of blood cancer as an adult

Scientists identify gene that causes hereditary hypertension and brachydactyly type E

Walnut-enriched diet may slow colorectal tumor growth

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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