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U.S. researchers report 'functional cure' for infant born with HIV

"A baby born with the virus that causes AIDS appears to have been cured, scientists announced Sunday, describing the case of a child from Mississippi who's now two and a half and has been off medication for about a year with no signs of active infection," the Associated Press reports.

5 Mar 2013

FES cycling associated with improvements in individuals with chronic spinal cord injury

A new study by Kennedy Krieger Institute's International Center for Spinal Cord Injury finds that long-term lower extremity functional electrical stimulation (FES) cycling, as part of a rehabilitation regimen, is associated with substantial improvements in individuals with chronic spinal cord injury (SCI).

5 Mar 2013

Discovery provides clues for potentially eliminating HIV infection in children

A two-year-old child born with HIV infection and treated with antiretroviral drugs beginning in the first days of life no longer has detectable levels of virus using conventional testing despite not taking HIV medication for 10 months, according to findings presented today at the Conference on Retroviruses and Opportunistic Infections in Atlanta.

5 Mar 2013

Mirabegron reduces frequency of incontinence episodes in phase III trial

In a new phase III trial mirabegron, a β3-adrenoceptor agonist, given once daily for 12 weeks, reduced the frequency of incontinence episodes and number of daily urinations, and improved urgency and nocturia in adults with overactive bladder compared to those in a placebo group.

5 Mar 2013

HIV might promote aging and disease progression in people with HCV, study results suggest

Infectious disease experts at Johns Hopkins have found that among people infected with the hepatitis C virus, co-infection with HIV, speeds damage and scarring of liver tissue by almost a decade.

5 Mar 2013

Cognitive behavioral therapy brings relief to people with diabetic neuropathies, researchers find

Researchers at Boston University School of Medicine and VA Boston Healthcare System have found that cognitive behavioral therapy can help relieve pain for people with painful diabetic neuropathies.

5 Mar 2013

Children with low-risk retinoblastoma do not need postoperative chemotherapy

New results from a prospective clinical trial conducted in France show that children with low-risk retinoblastoma do not need postoperative (adjuvant) chemotherapy to prevent disease recurrence or metastasis; the results also suggest that certain patients with intermediate-risk disease can receive less aggressive adjuvant treatment, or perhaps forego it altogether. Avoiding chemotherapy spares patients from treatment side effects and long-term health risks, such as cardiovascular disease and development of a second cancer.

5 Mar 2013

Study highlights long-term benefits of early antiretroviral therapy initiated in infants

A study led by University of Massachusetts Medical School professor and immunologist Katherine Luzuriaga, MD, and Johns Hopkins Children's Center virologist Deborah Persaud, MD, highlights the long-term benefits of early antiretroviral therapy (ART) initiated in infants.

5 Mar 2013

Express Scripts finds decline in 2012 U.S. spending on traditional prescription drugs

For the first time in more than 20 years, there was a decrease in 2012 U.S. spending on traditional prescription drugs — primarily pills people take to treat more common diseases such as high cholesterol and high blood pressure — according to new data released today by Express Scripts.

5 Mar 2013

Pediatric cancer charities collaborate to create new treatments for children with neuroblastoma

Solving Kids' Cancer, along with U.K.-based charities Neuroblastoma Alliance UK, J-A-C-K, and other European organizations have aligned forces to improve access to promising clinical trials for children with high-risk neuroblastoma in North America, the U.K. and Europe.

5 Mar 2013

Scientists discover how to detect abnormal brain rhythms associated with Parkinson's

A team of scientists and clinicians at UC San Francisco has discovered how to detect abnormal brain rhythms associated with Parkinson's by implanting electrodes within the brains of people with the disease.

5 Mar 2013

HCV and HIV co-infected patients achieve early treatment success with faldaprevir, PegIFN/RBV

Interim study results from STARTversoTM 4 presented today at CROI+ show that 80 percent of hepatitis C (HCV) patients also infected with HIV achieved early treatment success with faldaprevir (BI 201335) combined with pegylated interferon and ribavirin (PegIFN/RBV).

5 Mar 2013

HIV infection may increase risk of acute myocardial infarction

A study that analyzed data from more than 82,000 veterans suggests that infection with the human immunodeficiency virus (HIV) was associated with an increased risk of acute myocardial infarction (AMI, heart attack) beyond what is explained by recognized risk factors, according to a report published Online First by JAMA Internal Medicine, a JAMA Network publication.

4 Mar 2013

Positive results from NeuroDerm ND0612 Phase I trial on Parkinson's

NeuroDerm, Ltd. announced today the results of a Phase I safety and pharmacokinetic trial of ND0612, a novel drug formulation for the treatment of Parkinson's disease.

4 Mar 2013

Autistic children with severe language delay achieve phrase or fluent speech by age eight

New findings published in Pediatrics (Epub ahead of print) by the Kennedy Krieger Institute's Center for Autism and Related Disorders reveal that 70 percent of children with autism spectrum disorders (ASD) who have a history of severe language delay, achieved phrase or fluent speech by age eight.

4 Mar 2013

Chroma Therapeutics, CTI announce results from tosedostat Phase 2 study on AML

Cell Therapeutics, Inc. (CTI) and Chroma Therapeutics Ltd. announced today that Lancet Oncology has published results from the OPAL Phase 2 study of tosedostat in elderly patients with relapsed or refractory acute myeloid leukemia (AML).

4 Mar 2013

Older patients with head and neck cancers less likely to die in high-volume hospitals

A study of older patients with advanced head and neck cancers has found that where they were treated significantly influenced their survival.

4 Mar 2013

Prompt antiretroviral therapy may help infants clear the HIV and achieve long-term remission

A team of researchers from Johns Hopkins Children's Center, the University of Mississippi Medical Center and the University of Massachusetts Medical School describe the first case of a so-called "functional cure" in an HIV-infected infant. The finding, the investigators say, may help pave the way to eliminating HIV infection in children.

4 Mar 2013

Study identifies two gene mutations that lead to death of nerve cells in ALS

A study led by St. Jude Children's Research Hospital has discovered mutations in two genes that lead to the death of nerve cells in amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, and related degenerative diseases.

4 Mar 2013

Regeneron, Sanofi announce pooled data from Phase 1b trials with dupilumab for atopic dermatitis

Sanofi and Regeneron Pharmaceuticals, Inc. announced that pooled data from two Phase 1b trials with dupilumab (REGN668/SAR231893), an investigational, high-affinity, subcutaneously administered, fully-human antibody targeting the alpha subunit of the interleukin 4 receptor (IL-4R alpha), were presented at the 71st Annual Meeting of the American Academy of Dermatology (AAD) in Miami.

4 Mar 2013

Therapy News and Research

U.S. researchers report 'functional cure' for infant born with HIV

FES cycling associated with improvements in individuals with chronic spinal cord injury

Discovery provides clues for potentially eliminating HIV infection in children

Mirabegron reduces frequency of incontinence episodes in phase III trial

HIV might promote aging and disease progression in people with HCV, study results suggest

Cognitive behavioral therapy brings relief to people with diabetic neuropathies, researchers find

Children with low-risk retinoblastoma do not need postoperative chemotherapy

Study highlights long-term benefits of early antiretroviral therapy initiated in infants

Express Scripts finds decline in 2012 U.S. spending on traditional prescription drugs

Pediatric cancer charities collaborate to create new treatments for children with neuroblastoma

Scientists discover how to detect abnormal brain rhythms associated with Parkinson's

HCV and HIV co-infected patients achieve early treatment success with faldaprevir, PegIFN/RBV

HIV infection may increase risk of acute myocardial infarction

Positive results from NeuroDerm ND0612 Phase I trial on Parkinson's

Autistic children with severe language delay achieve phrase or fluent speech by age eight

Chroma Therapeutics, CTI announce results from tosedostat Phase 2 study on AML

Older patients with head and neck cancers less likely to die in high-volume hospitals

Prompt antiretroviral therapy may help infants clear the HIV and achieve long-term remission

Study identifies two gene mutations that lead to death of nerve cells in ALS

Regeneron, Sanofi announce pooled data from Phase 1b trials with dupilumab for atopic dermatitis

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