Therapy News and Research

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Cortisol and white matter integrity relationship disrupted in bipolar disorder

Researchers have found evidence in support of hypercortisol-induced glial dysfunction affecting periventricular white matter integrity in patients with bipolar disorder.

14 Feb 2013

Nerve stimulation could stave off migraine attacks

Transcutaneous stimulation of the trigeminal nerve has shown promise as a treatment for migraine, according to results of a randomized controlled trial.

14 Feb 2013

Researchers ESTABLISH efficacy of tedizolid phosphate for skin infections

Results from the phase III ESTABLISH-1 study show that the new antibiotic tedizolid phosphate is noninferior to linezolid for the treatment of acute bacterial and skin structure infections.

14 Feb 2013

Long’s manipulation enhances massage for chronic neck pain

Long’s manipulation, a Chinese manipulation approach that incorporates spinal manipulation and traditional Chinese massage, appears to be more effective for treating chronic mechanical neck pain than massage alone, study findings show.

14 Feb 2013

Researcher to study ADAM12 gene in breast tumor initiating cells

A Kansas State University professor's research on breast cancer stem cells may help improve survival rates by preventing cancer recurrence and metastasis -- the major causes of death among breast cancer patients.

14 Feb 2013

Combination of Methotrexat and Tofacitinib shows promise against rheumatoid arthritis

Together with colleagues from the international rheumatic diseases research community, scientists of the Charité - Universitätsmedizin Berlin have presented a new therapy approach for the treatment of rheumatoid arthritis (RA), a chronic form of joint inflammation.

14 Feb 2013

FDA grants IDE approval to STS and ACC to study alternative access approaches for TAVR

The Society of Thoracic Surgeons (STS) and the American College of Cardiology (ACC) have received a unique investigational device exemption (IDE) from the U.S. Food and Drug Administration (FDA) to study "alternative access" approaches for transcatheter aortic valve replacement (TAVR) using the STS/ACC TVT Registry.

14 Feb 2013

FOXC2 vital to epithelial-mesenchymal transition in breast cancer

Researchers have identified a pivotal protein in a cellular transformation that makes a cancer cell more resistant to treatment and more capable of growing and spreading, making it an inviting new target for drug development.

14 Feb 2013

GSK1322322 targets gram-positive bacteria including methicillin-resistant strains of MRSA

An increasing number of bacteria is evolving antibiotic resistance. Much-feared representatives of this steadily growing group include Staphylococci strains. At this point, multi-resistant forms of the bacterium Staphylococcus aureus - the "hospital germ" known commonly by its acronym, MRSA - can only be treated with a select subset of antibiotics as many drugs have simply stopped working. This is precisely why the field of medicine is in desperate need of new treatment options.

14 Feb 2013

Will more availability of some Medicare therapies spark a budget crisis?

Politico looks at how making some therapies more widely available to Medicare recipients -- as one lawsuit is asking for -- could strain the program's budget. In addition, The Associated Press examines Medicare records to find that monitoring some kidney cancer patients instead of operating could improve their chances to live.

14 Feb 2013

Novel approach uses adult stem cells to save sight of diabetes sufferers

Scientists at Queen's University Belfast are hoping to develop a novel approach that could save the sight of millions of diabetes sufferers using adult stem cells.

14 Feb 2013

Study demonstrates how CN2097 works to restore neural functions impaired by Angelman syndrome

In a new study in mice, a scientific collaboration centered at Brown University lays out in unprecedented detail a neurological signaling breakdown in Angelman syndrome, a disorder that affects thousands of children each year, characterized by developmental delay, seizures, and other problems.

14 Feb 2013

FDA allows Scioderm’s SD-101 IND application for Epidermolysis Bullosa to proceed

Scioderm announced that the US Food and Drug Administration (FDA) has reviewed and allowed the investigational new drug (IND) application for SD-101 to proceed. SD-101 is a topical treatment being developed for the treatment of Epidermolysis Bullosa (EB).

14 Feb 2013

Blood’s tendency to clot may contribute to white matter hyperintensities in post-menopausal women

New Mayo Clinic research suggests that blood may hold clues to whether post-menopausal women may be at an increased risk for areas of brain damage that can lead to memory problems and possibly increased risk of stroke. The study shows that blood's tendency to clot may contribute to areas of brain damage called white matter hyperintensities.

14 Feb 2013

Meridian receives ADA's Certificate of Education Recognition for diabetes education program

The American Diabetes Association (ADA) has awarded Meridian Medical Associates a Certificate of Education Recognition for its diabetes self-management education program.

13 Feb 2013

Ability to tune gene activity will permit refined research for drug resistance, cancer

Scientists who built a synthetic gene circuit that allowed for the precise tuning of a gene's expression in yeast have now refined this new research tool to work in human cells, according to research published online in Nature Communications.

13 Feb 2013

Tivozanib overall survival results announced by AVEO and Astellas

AVEO Oncology (NASDAQ: AVEO) and Astellas Pharma Inc. (TSE: 4503) announced overall survival (OS) for tivozanib, an investigational agent, from the Phase 3 TIVO-1 (TIvozanib Versus sOrafenib in 1st line advanced RCC) study in patients with advanced renal cell carcinoma (RCC). The final OS analysis, as specified by the protocol, shows a median OS of 28.8 months (95% confidence interval [CI]: 22.5–NA) for tivozanib versus a median OS of 29.3 months (95% CI: 29.3–NA) for the comparator arm, sorafenib.

13 Feb 2013

Scopolamine may also be possible treatment for anxiety disorders

However, scopolamine is re-emerging as an antidepressant, with recent studies showing that scopolamine can rapidly improve mood in depressed patients. In addition, in a new study published in Biological Psychiatry this month by Dr. Moriel Zelikowsky and colleagues at the University of California, Los Angeles, it may also be a possible treatment for anxiety disorders.

13 Feb 2013

HRI to begin enrollment in RAD001 Phase II trial for Neurofibromatosis Type-2

House Research Institute (HRI) is recruiting patients for a Phase II clinical trial to test a medication that may slow the progression of Neurofibromatosis Type-2, commonly referred to as NF2.

13 Feb 2013

New drug delivery system can reduce size of ovarian tumors by as much as 83%

By loading fragile RNA into silicon nanoparticles, researchers from The Methodist Hospital and two other institutions found a new drug delivery system can reduce the size of ovarian tumors by as much as 83 percent -- and stop tumor growth in chemotherapy-resistant ovarian cancer tissue.

13 Feb 2013

Therapy News and Research

Cortisol and white matter integrity relationship disrupted in bipolar disorder

Nerve stimulation could stave off migraine attacks

Researchers ESTABLISH efficacy of tedizolid phosphate for skin infections

Long’s manipulation enhances massage for chronic neck pain

Researcher to study ADAM12 gene in breast tumor initiating cells

Combination of Methotrexat and Tofacitinib shows promise against rheumatoid arthritis

FDA grants IDE approval to STS and ACC to study alternative access approaches for TAVR

FOXC2 vital to epithelial-mesenchymal transition in breast cancer

GSK1322322 targets gram-positive bacteria including methicillin-resistant strains of MRSA

Will more availability of some Medicare therapies spark a budget crisis?

Novel approach uses adult stem cells to save sight of diabetes sufferers

Study demonstrates how CN2097 works to restore neural functions impaired by Angelman syndrome

FDA allows Scioderm’s SD-101 IND application for Epidermolysis Bullosa to proceed

Blood’s tendency to clot may contribute to white matter hyperintensities in post-menopausal women

Meridian receives ADA's Certificate of Education Recognition for diabetes education program

Ability to tune gene activity will permit refined research for drug resistance, cancer

Tivozanib overall survival results announced by AVEO and Astellas

Scopolamine may also be possible treatment for anxiety disorders

HRI to begin enrollment in RAD001 Phase II trial for Neurofibromatosis Type-2

New drug delivery system can reduce size of ovarian tumors by as much as 83%

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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