Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Chemotherapy and cancer join together to cause neuropathy

Contrary to common medical guidance, chemotherapy does not appear to be the only culprit in neuropathy, a neurological side effect of cancer treatment, a new study says. Cancer itself contributes heavily, too, and the stresses on neurons appear far worse than the sum of the two causes.

8 Jun 2020

Researchers confirm new therapeutic target for myelodysplastic syndrome

A research group from Kumamoto University, Japan analyzed the pathophysiology of myelodysplastic syndrome (MDS), a blood cancer that presents often in the elderly, and found the presence of the transcription factor RUNX3, thereby revealing a cancer growth function for what had been considered a tumor suppressor.

8 Jun 2020

Gene expression may be a decisive factor for controlling possible comorbidities

A study led by the Barcelona Supercomputing Center, in which the Universitat de València participates, concludes that the specific characteristics of each patient, such as gene expression, may be a decisive factor in the development of clinical strategies aimed at addressing and controlling possible comorbidities.

8 Jun 2020

Researchers use single-cell-resolution technologies to map brain genes in humans

A group of scientists led by Philipp Khaitovich, a professor at Skoltech, conducted a large-scale study of gene expression in 33 different brain regions of humans, chimpanzees, macaques and bonobos using the single-cell-resolution transcriptomics technologies and made a map of the different brain regions with their specific cell structures.

5 Jun 2020

New images of LSD1 enzyme in action shed light on gene regulation

New images of an enzyme in action as it interacts with the chromosome could provide important insight into how cells--including cancer cells--regulate their genes.

5 Jun 2020

UIC Center for Alcohol Research in Epigenetics receives $8.2 million NIH grant

The University of Illinois at Chicago received $8.2 million from the National Institute on Alcohol Abuse and Alcoholism to continue the Center for Alcohol Research in Epigenetics and its research on how alcohol affects genes through epigenetics -- chemical changes to DNA, RNA or proteins that alter the expression of genes without directly modifying them.

4 Jun 2020

New insights into how parenteral oil emulsions prevent liver disease in preterm babies

Infants born prematurely may require parenteral or intravenous nutrition to provide the necessary nourishment, as their digestive system is immature and cannot digest nutrients.

4 Jun 2020

Scientists provide clarity into how cells remember their identity

Cancer is often the result of DNA mutations or problems with how cells divide, which can lead to cells "forgetting" what type of cell they are or how to function properly.

4 Jun 2020

LMU researchers discover how a microRNA preserves vascular integrity

Ludwig-Maximilian-Universitaet in Munich researchers have discovered a hitherto unknown molecular function of a specific microRNA that preserves integrity of the endothelium and reduces the risk of atherosclerosis.

4 Jun 2020

Gleason grade group 5 prostate cancer can be divided into subtypes with distinct differences

Researchers at the UCLA Jonsson Comprehensive Cancer Center analyzed gene-expression patterns in the most aggressive prostate cancer grade group -- known as Gleason grade group 5 -- and found that this grade of cancer can actually be subdivided into four subtypes with distinct differences.

4 Jun 2020

Human protein plays key role in transcription and genome integrity

Researchers from the University of Seville and Cabimer discover that the UAP56/DDX39B protein remove DNA-RNA hybrids from the genome

4 Jun 2020

Scientists uncover why developing nerve cells take a wrong turn

A group of scientists from CECAD, the Cluster of Excellence 'Cellular Stress Responses in Aging-Associated Diseases,' have found a mechanism by which neurodevelopmental diseases concerning neurons can be explained: The loss of a certain enzyme, UBE2K, impeded the differentiation of stem cells by silencing the expression of genes important for neuronal differentiation and, therefore, the development and generation of neurons.

3 Jun 2020

Study reveals how a fat cell's immune response worsens obesity

When obesity occurs, a person's own fat cells can set off a complex inflammatory chain reaction that can further disrupt metabolism and weaken immune response--potentially placing people at higher risk of poor outcomes from a variety of diseases and infections, including COVID-19.

2 Jun 2020

Explosion of immune cells in mouse lungs after birth may help protect against infections

An explosion in the number and types of immune cells in the lungs of newborn mice likely helps them adapt to breathing and protects them from infection, says a new study published today in eLife.

2 Jun 2020

Researchers identify key protein required for optimal immune responses to cancer

A new study led by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Solove Research Institute (OSUCCC - James) has identified a protein within certain immune cells that is required for optimal immune responses to cancer.

2 Jun 2020

Toshiba and Shinshu University jointly develop a 'tumor-tropic liposome technology' for gene therapy

Toshiba Corporation and a team led by Professor Yozo Nakazawa at the Department of Pediatrics, Shinshu University, have together developed a “tumor-tropic liposome technology” for gene therapy. The technology uses unique, nano-sized biodegradable liposomes developed by Toshiba to accurately and efficiently deliver therapeutic genes to targeted cancer cells, and achieves safer gene delivery than viruses used as carriers.

30 May 2020

Researchers design developmental map of sound-sensing structure in mice’s inner ear

A team of researchers has generated a developmental map of a key sound-sensing structure in the mouse inner ear.

30 May 2020

How comorbidities affect SARS-CoV-2 viral entry

Almost from the start of the current COVID-19 pandemic, it has become clear that individuals suffering from other medical conditions like diabetes, cardiovascular disease, and lung disease are far more likely to contract the infection and to have a poorer outcome.

28 May 2020

Ludwig Cancer Research study profiles immune landscape of brain tumors

A Ludwig Cancer Research study has profiled, in a sweeping comparative analysis, the distinct immune landscapes of tumors that arise in the brain, or gliomas, and those that metastasize to the organ from the lungs, breast and skin.

28 May 2020