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Scientists describe dynamic genomic landscape of tumor heterogeneity in hepatocellular carcinoma

Clinician scientists and scientists from the National Cancer Centre Singapore and A*STAR's Genome Institute of Singapore, in collaboration with Singapore General Hospital, the National University Health System, Duke-NUS Medical School, Nanyang Technological University, and collaborators from China, Malaysia, Thailand and the Philippines, have described a dynamic genomic landscape of tumour heterogeneity in hepatocellular carcinoma (HCC).

13 Dec 2021

Characteristics of vaccine breakthroughs in fully vaccinated individuals in France with delta variant

In a recent observational study, scientists have described the characteristics of VBIs in fully vaccinated individuals in France.

13 Dec 2021

Diversity in genetic data improves the ability to predict high cholesterol risk

Including data from people of diverse ancestries substantially improves certain genetic risk predictions in all populations, according to a study that examined the genes responsible for regulating blood cholesterol levels.

13 Dec 2021

Autonomous genome annotation of SARS-CoV-2 genes, proteins and domains

In a new research paper, a group of scientists from various institutions offers a semi-supervised custom pipeline for annotating all SARS-CoV-2 genes, proteins, and functional domains.

12 Dec 2021

A pandemic-scale phylogenetic analysis tool

Researchers develop a phylogenetic package that incorporated several pandemic-specific optimization and parallelization techniques.

12 Dec 2021

New tool to help map immune escape with SARS-CoV-2 mutations

A new study discusses a computational program that can be used to substitute for actual experimental evidence of the biologic impact of new mutations.

12 Dec 2021

First locally acquired infection of Omicron variant confirmed in San Diego

Officials at the San Diego County Health and Human Services Agency, working in collaboration with scientists at University of California San Diego and Scripps Research, have announced the second confirmed case — and first locally acquired infection — of the Omicron variant of SARS-CoV-2, the virus that causes COVID-19.

12 Dec 2021

LSHTM's new modeling estimates the potential impact of omicron in England

New modeling from the London School of Hygiene & Tropical Medicine suggests the Omicron variant has the potential to cause a wave of transmission in England that could lead to higher levels of cases and hospitalizations than those seen during January 2021, if additional control measures are not taken.

12 Dec 2021

Evolution of the SARS-CoV-2 omicron variant

Study shows that the omicron variant shares a common ancestry with the VOI lambda and has evolved mainly because of non-synonymous mutations.

9 Dec 2021

Mass-spectrometry and PCR testing identifies various targets related to SARS-CoV-2 VOCs

New research posted to the medRxiv* preprint server suggests that the Agena MassARRAY SARS-CoV-2 Panel PCR test effectively detects a variety of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants.

9 Dec 2021

Researchers identify a molecular culprit for COVID-19's seasonal nature

Not to pile on, but winter is coming and the COVID-19 pandemic is about to get worse. Not necessarily because of omicron – scientists are still working that one out – but because there’s more evidence than ever that COVID-19 is a seasonal disease.

8 Dec 2021

Diverse genome sequences generate a polygenic risk score to predict heart disease risk

In a large-scale study of people from diverse ancestries, researchers narrowed down the number of genomic variants that are strongly associated with blood lipid levels and generated a polygenic risk score to predict elevated low-density lipoprotein cholesterol levels, a major risk factor for heart disease.

8 Dec 2021