Membrane News and Research

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Production of six monoclonal antibodies against SARS-CoV-2 spike protein

Youjia Guo et al. in a recent bioRxiv preprint paper demonstrate the robust performance of mouse anti-SARS-CoV-2 spike monoclonal antibodies in immunoassays, including western blotting, ELISA, immunofluorescence, and immunoprecipitation and also neutralizing activity in vitro against SARS-CoV-2 infection.

5 Oct 2020

Development of a coarse-grained model of SARS-CoV-2 virion

A team of scientists of the University of Chicago and the University of California San Diego has developed a coarse-grained (CG) model of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virion. The model can be used as a valuable resource to perform multiscale simulations of the SARS-CoV-2 virion. The study is currently available on the bioRxiv* preprint server.

5 Oct 2020

Eli Lilly's LY-CoV555 antibody shows potential as COVID-19 treatment

Researchers in the United States and Canada have discovered a monoclonal antibody that potently neutralizes severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent responsible for the current coronavirus disease 2019 (COVID-19) pandemic.

5 Oct 2020

Macrophage subgroups may play pivotal role in COVID-19 lethality

Many researchers are attempting to identify risk factors for severe or critical COVID-19. A recent paper in the journal Medical Hypotheses in September 2020 suggests that macrophage class activation is one of the factors that determine the clinical phenotype of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

5 Oct 2020

Advanced model reveals dynamic motions of SARS-COV-2 spike-shielding glycans

A recent paper published on the preprint server bioRxiv in September 2020 discusses the dynamic interactions of the spike protein glycan shield, which may be of great value in developing therapeutic compounds to fight severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

5 Oct 2020

Understanding how the malaria parasite can withstand fever's heat

Even when a person suffering from malaria is burning up with fever and too sick to function, the tiny blood-eating parasites lurking inside them continue to flourish, relentlessly growing and multiplying as they gobble up the host's red blood cells.

5 Oct 2020

Potential drug treatment for AXL-low expressing EGFR-mutated lung cancer

Researchers at Kanazawa University report in Nature Communications the mechanism making some lung-cancer patients resistant to the drug osimertinib.

5 Oct 2020

New approach transforms oldest antibiotics into safer, stronger drugs

Physicians and scientists have long searched the natural world for chemicals that can improve human health. However, evolutionary selection optimized natural chemicals to benefit their host, not for safety or efficacy in humans.

5 Oct 2020

Furin cleavage site of SARS-CoV-2 spike glycoprotein enhances viral replication in the lungs

In a new bioRxiv* preprint paper, researchers from the Imperial College London, King's College London, and the University of Bristol in the United Kingdom show that the furin cleavage site of SARS-CoV-2 spike glycoprotein represents a key determinant for transmission among humans, as it substantially facilitates replication in airway cells - opening the door for the development of novel therapeutics.

4 Oct 2020

Machine learning can predict pediatric ECMO patients at risk of brain injury

When newborn babies or children with heart or lung distress are struggling to survive, doctors often turn to a form of life support that uses artificial lungs.

1 Oct 2020

Planaria flatworm can be used as reliable alternative for testing topical skin products

Tests for skin treatments could be screened using flatworms rather than other animals such as rabbits, according to new research.

1 Oct 2020

Researchers unravel new mechanism of cell survival in chronic lymphocytic leukemia

Researchers at The Wistar Institute unraveled a mechanism employed by chronic lymphocytic leukemia (CLL) cells for their survival.

30 Sep 2020

Researchers develop research model to understand the impact of coronavirus on lungs

Scientists at Boston University's National Emerging Infectious Diseases Laboratories (NEIDL) and the Center for Regenerative Medicine (CReM) joined forces to develop the most relevant research model possible for understanding how the coronavirus virus impacts the lungs, by engineering living, "breathing" human lung cells from stem cells for the task.

30 Sep 2020

Exosomes yield regenerative benefits equivalent to hiPSC-CCs, shows study

Science has long known that recovery from experimental heart attacks is improved by injection of a mixture of heart muscle cells, endothelial cells and smooth muscle cells, yet results have been limited by poor engraftment and retention, and researchers worry about potential tumorigenesis and heart arrhythmia.

30 Sep 2020

New artificial lung developed to support pre-term babies in respiratory distress

An international team led by current and former McMaster University researchers has developed an artificial lung to support pre-term and other newborn babies in respiratory distress.

29 Sep 2020

Discovery of specific kinase as a novel drug target against SARS-CoV-2 and other coronaviruses

By using a modern genome-wide knockout approach to single out coronavirus host factors in human cells, researchers from Rega Institute in Belgium discovered a potential new target that might be exploited for developing drugs against the ongoing coronavirus disease (COVID-19) pandemic, but also future outbreaks of highly pathogenic coronaviruses

29 Sep 2020

Study unravels how lysosomal damage response pathways prevent kidney injury

Human cells need to work like well-oiled machines to keep our bodies running as they should. Waste products such as misfolded proteins, damaged cellular components, and carbohydrates get in the way and must be quickly disposed of.

28 Sep 2020

Stanford researchers unravel how a common genetic deletion elevates schizophrenia risk

A common genetic deletion boosts the risk for schizophrenia by 30-fold. Generating nerve cells from people with the deletion has showed Stanford researchers why.

28 Sep 2020

CRISPR screening identifies human host pathways that facilitate coronavirus infection

The human coronavirus family consists of 7 known pathogens, for which there are no approved vaccines or specific therapeutic options. Although the seasonal human coronaviruses - OC43, HKU1, 229E, and NL63 – only cause mild respiratory infections, three highly pathogenic coronaviruses that emerged in the last two decades revealed the pandemic potential of this family of viruses.

27 Sep 2020

ECMO appears to be saving the lives of many critically ill COVID-19 patients

It saved lives in past epidemics of lung-damaging viruses. Now, the life-support option known as ECMO appears to be doing the same for many of the critically ill COVID-19 patients who receive it, according to a new international study.

26 Sep 2020

Membrane News and Research

Production of six monoclonal antibodies against SARS-CoV-2 spike protein

Development of a coarse-grained model of SARS-CoV-2 virion

Eli Lilly's LY-CoV555 antibody shows potential as COVID-19 treatment

Macrophage subgroups may play pivotal role in COVID-19 lethality

Advanced model reveals dynamic motions of SARS-COV-2 spike-shielding glycans

Understanding how the malaria parasite can withstand fever's heat

Potential drug treatment for AXL-low expressing EGFR-mutated lung cancer

New approach transforms oldest antibiotics into safer, stronger drugs

Furin cleavage site of SARS-CoV-2 spike glycoprotein enhances viral replication in the lungs

Machine learning can predict pediatric ECMO patients at risk of brain injury

Planaria flatworm can be used as reliable alternative for testing topical skin products

Researchers unravel new mechanism of cell survival in chronic lymphocytic leukemia

Researchers develop research model to understand the impact of coronavirus on lungs

Exosomes yield regenerative benefits equivalent to hiPSC-CCs, shows study

New artificial lung developed to support pre-term babies in respiratory distress

Discovery of specific kinase as a novel drug target against SARS-CoV-2 and other coronaviruses

Study unravels how lysosomal damage response pathways prevent kidney injury

Stanford researchers unravel how a common genetic deletion elevates schizophrenia risk

CRISPR screening identifies human host pathways that facilitate coronavirus infection

ECMO appears to be saving the lives of many critically ill COVID-19 patients

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