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Ramipril may improve pain-free walking among patients with PAD and intermittent claudication

Among patients with peripheral artery disease and intermittent claudication (pain in the calf that comes and goes, typically felt while walking), 24 weeks of treatment with the angiotensin-converting enzyme (ACE) inhibitor ramipril was associated with improvement in pain-free and maximum walking times and the physical health aspect of quality of life, according to a study appearing in the February 6 issue of JAMA.

6 Feb 2013

Oleuropein aglycone reduces inflammation associated with intestinal ischemia and reperfusion

Here's another reason why you should include olive oil in your diet: A new research report published in the Journal of Leukocyte Biology suggests that at least one compound in olive oil significantly reduces intestinal ischemia (restricted blood supply) and the resulting reperfusion injury (tissue damage caused when blood supply returns).

6 Feb 2013

Teva initiates enrollment in AZILECT Phase IV clinical study for PD-MCI

Teva Pharmaceutical Industries Ltd. announced today enrollment of the first patient in the MODERATO study - a Phase IV clinical study designed to evaluate the effect of AZILECT (rasagiline tablets) on cognitive function in adults with mild cognitive impairment (MCI) in Parkinson's disease (PD-MCI).

6 Feb 2013

Thoratec fourth quarter revenues increase 17% to $128.5 million

Thoratec Corporation, a world leader in device-based mechanical circulatory support therapies to save, support and restore failing hearts, today reported its financial results for the fourth quarter of 2012.

5 Feb 2013

Survivors of CNS cancer in childhood are at increased risk for disturbance in body image

Survivors of cancer of the central nervous system (CNS) in childhood are at heightened risk for disturbance in body image and self-image in relation to sports or other physical activities, according to a nationwide study from Karolinska Institutet in Sweden published in the Journal of Neuro-Oncology.

5 Feb 2013

Previously poorly investigated signalling pathway crucial for proliferation of prostate cancer cells

A previously poorly investigated signalling pathway is crucial for the growth and proliferation of prostate cancer cells. An international research team discovered this when studying the enzyme "soluble adenylyl cyclase" that produces the second messenger molecule cAMP.

5 Feb 2013

Viracor-IBT Laboratories signs definitive agreement to purchase assets of Cylex

Viracor-IBT Laboratories, Inc. announced today that it has signed a definitive agreement to purchase the assets of Cylex, Inc., a global life sciences company focused on the development, manufacturing and commercialization of in vitro diagnostic products intended to illuminate immunity in the area of transplant medicine.

5 Feb 2013

Caution on COX inhibitor use in preterm infants

Very-low-birthweight preterm infants with thrombocytopenia treated with cyclooxygenase inhibitors are at an increased risk for intracerebral hemorrhage, particularly if they have decreased platelet levels, research shows.

5 Feb 2013

Detection of B cells may predict graft-versus-host disease

The ability to detect B cells specific to the DEAD box protein may help predict the development of chronic graft-versus-host disease in male recipients of female hematopoietic cells, according to recent findings.

5 Feb 2013

Location of altered brain metabolite levels found in bipolar I patients

Bipolar I disorder patients have increased phospholipid levels in the thalami and increased N-acetyl-aspartate levels in the left hippocampus compared with healthy individuals, a team of investigators has discovered.

5 Feb 2013

UCSD receives $3.4M NIMH grant to study successful aging in HIV-infected adults

The National Institute of Mental Health has awarded a $3.4 million grant to a team of researchers at the University of California, San Diego School of Medicine to study successful aging in HIV-infected adults. HIV is a serious, chronic, medical disease that affects the lives of more than one million Americans.

5 Feb 2013

GLP-1 receptor agonists associated with reduced BMI in adolescents with severe obesity

Preliminary evidence from a clinical trial suggests that treatment with glucagon-like peptide-1 (GLP-1) receptor agonists was associated with reduced body mass index and body weight in adolescents with severe obesity, according to a report published Online First by JAMA Pediatrics, a JAMA Network publication.

5 Feb 2013

Results from Merck’s Vorinostat phase 1 trial on lymphoma

Patients whose aggressive lymphomas have relapsed or failed to respond to the current front-line chemotherapy regimen now have an effective second line of attack against their disease.

5 Feb 2013

Orphan, St George's sign licensing agreement to develop new therapies for metabolic disorders

St George's, University of London has signed an exclusive worldwide licensing agreement with rare-disease research-and-development firm Orphan Technologies Ltd to develop new therapies for deadly metabolic disorders.

5 Feb 2013

UPCI researchers uncover new technique to stop growth of cancer cells

University of Pittsburgh Cancer Institute (UPCI) researchers have uncovered a technique to halt the growth of cancer cells, a discovery that led them to a potential new anti-cancer therapy.

5 Feb 2013

ATI Neurostimulation System demonstrates clinical effectiveness in treating cluster headache

Autonomic Technologies, Inc. (ATI), the developer of the ATI Neurostimulation System designed for the treatment of severe headaches, today announced results of their clinical study in cluster headache, now published online in Cephalalgia.

5 Feb 2013

NeuroSigma receives third NIH grant to develop subcutaneous trigeminal nerve stimulation for DRE

NeuroSigma, Inc., a California-based medical device company, today announced it received a Notice of Award, for a Fast Track Small Business Innovation Research (SBIR) grant, from the National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH).

5 Feb 2013

Loyola Flu Central now available on LUHS web site

Loyola Flu Central, a weekly snapshot of flu activity locally, regionally and nationally is now available on the Loyola University Health System web site, through Twitter and on Facebook.

5 Feb 2013

The Journal of Urology publishes results from BioSpecifics XIAFLEX trials on Peyronie's disease

BioSpecifics Technologies Corp., a biopharmaceutical company developing first in class collagenase-based products marketed as XIAFLEX in the U.S. and XIAPEX in Europe and Eurasia, today announced that The Journal of Urology has electronically published the uncorrected proof of the pivotal IMPRESS (The Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies) trials on its website.

5 Feb 2013

PET with 11C-PIB can positively visualize amyloid deposits in the heart

While amyloid imaging may now be most associated with detecting plaques in the brain, it has the potential to change the way cardiac amyloidosis is diagnosed. According to first-of-its-kind research published in the February issue of The Journal of Nuclear Medicine, positron emission tomography (PET) with 11C-PIB can positively visualize amyloid deposits in the heart.

5 Feb 2013

Therapy News and Research

Ramipril may improve pain-free walking among patients with PAD and intermittent claudication

Oleuropein aglycone reduces inflammation associated with intestinal ischemia and reperfusion

Teva initiates enrollment in AZILECT Phase IV clinical study for PD-MCI

Thoratec fourth quarter revenues increase 17% to $128.5 million

Survivors of CNS cancer in childhood are at increased risk for disturbance in body image

Previously poorly investigated signalling pathway crucial for proliferation of prostate cancer cells

Viracor-IBT Laboratories signs definitive agreement to purchase assets of Cylex

Caution on COX inhibitor use in preterm infants

Detection of B cells may predict graft-versus-host disease

Location of altered brain metabolite levels found in bipolar I patients

UCSD receives $3.4M NIMH grant to study successful aging in HIV-infected adults

GLP-1 receptor agonists associated with reduced BMI in adolescents with severe obesity

Results from Merck’s Vorinostat phase 1 trial on lymphoma

Orphan, St George's sign licensing agreement to develop new therapies for metabolic disorders

UPCI researchers uncover new technique to stop growth of cancer cells

ATI Neurostimulation System demonstrates clinical effectiveness in treating cluster headache

NeuroSigma receives third NIH grant to develop subcutaneous trigeminal nerve stimulation for DRE

Loyola Flu Central now available on LUHS web site

The Journal of Urology publishes results from BioSpecifics XIAFLEX trials on Peyronie's disease

PET with 11C-PIB can positively visualize amyloid deposits in the heart

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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