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Burnt-out employees have increased risk of heart disease, researcher finds

Americans work longer hours, take fewer vacation days, and retire later than employees in other industrialized countries around the globe.

13 Mar 2013

RELAX study finds no beneficial effects of erectile dysfunction drug for diastolic heart failure

Despite high expectations for a commonly used erectile dysfunction drug to treat patients with diastolic heart failure, no beneficial effects were found in a study presented today at the American College of Cardiology's 62nd Annual Scientific Session.

13 Mar 2013

Restored Hearing to launch clinical trials to find cure for permanent tinnitus

Restored Hearing, a company established by physics students from University College Dublin and the University of Edinburgh, is preparing to launch a series of clinical trials in Edinburgh to see if its 'sound therapy' for temporary tinnitus can be used to treat a more serious permanent 'ringing in the ears'.

13 Mar 2013

Mini-chromosome maintenance protein can change DNA topology: Study

A team of USC scientists has identified a protein that can change DNA topology, making DNA twist up into a so-called "supercoil."

12 Mar 2013

Cangrelor solidly outperforms clopidogrel during percutaneous coronary intervention

The experimental anti-clotting drug cangrelor solidly outperformed commonly used clopidogrel in a large global trial of patients who underwent coronary stent procedures, according to data from the phase III CHAMPION PHOENIX study presented today at the American College of Cardiology's 62nd Annual Scientific Session.

12 Mar 2013

Aliskiren and standard therapy not associated with reduced CV death or HF rehospitalization

Among patients hospitalized for heart failure (HF) with reduced left ventricular ejection fraction (LVEF; a measure of how well the left ventricle of the heart pumps with each contraction), initiation of the medication aliskiren in addition to standard therapy did not reduce cardiovascular death or HF rehospitalization at 6 or 12 months after discharge, according to a study published online by JAMA.

12 Mar 2013

Results from Orion Pharma’s ORM-12741 phase IIa study on AD

A new drug may improve memory problems in people with moderate Alzheimer's disease, according to a phase IIa study released today that will be presented at the American Academy of Neurology's 65th Annual Meeting in San Diego, March 16 to 23, 2013. The drug is called ORM-12741.

12 Mar 2013

Addition of niacin to statin does not improve HDL function

While two large clinical trials recently showed that adding niacin to statin therapy failed to improve clinical outcomes despite a significant increase in HDL-C levels, little is known about exactly why the increased HDL-C levels did not reduce the risk of cardiovascular events, including heart attack and stroke.

12 Mar 2013

NIH-sponsored comparative trial evaluates benefits of combination therapy and monotherapy in MS

People with multiple sclerosis (MS) who were treated with combination therapy did not see significant clinical benefit over those treated with single drug therapy, but combination therapy did reduce the development of new lesions, according to an international research team led by The Mount Sinai Medical Center.

12 Mar 2013

$Sildenafil does not improve exercise capacity in HF patients with preserved ejection fraction$

Sildenafil does not improve exercise capacity in HF patients with preserved ejection fraction

Among patients with heart failure with preserved ejection fraction (a measure of heart function), administration of sildenafil for 24 weeks, compared with placebo, did not result in significant improvement in exercise capacity or clinical status, according to a study published online by JAMA.

12 Mar 2013

Nearly two-thirds of women with ovarian cancer do not receive guideline-adherent care

Women are 30 percent less likely to die of ovarian cancer if they have guideline-recommended treatment, yet nearly two-thirds of those with the disease do not receive it, often because they are cared for at hospitals that treat a small number of ovarian cancer patients.

12 Mar 2013

Combination of INF and glatiramer acetate does not reduce MS progression

A recent clinical trial found that interferonβ-1a (INF) and glatiramer acetate (GA), two of the most commonly prescribed drugs for multiple sclerosis (MS), provide no additional clinical benefit when taken together.

12 Mar 2013

$Sildenafil does not help heart failure patients with preserved ejection fraction$

Sildenafil does not help heart failure patients with preserved ejection fraction

A commonly used erectile dysfunction drug, sildenafil, doesn't help patients who have heart failure with preserved ejection fraction, a condition in which the heart's lower chambers are stiff and cannot relax and fill fully between beats.

12 Mar 2013

UniStem Day 2013 to take place on Mar. 15

This year, six Spanish universities participate in UniStem Day 2013, an event that takes place next Friday, 15th March. It is the first time that the event is carried out simultaneously in several European countries.

12 Mar 2013

New Sapien XT aortic valve reduces rate of death and strokes

The new Sapien XT aortic valve showed a non-significantly lower rate of death and strokes at 30 days than the original model, and both valves demonstrated notably better short-term outcomes than seen with the Sapien system in PARTNER I, according to the first results from the PARTNER II study presented today at the American College of Cardiology's 62nd Annual Scientific Session.

12 Mar 2013

Study: No increase in mortality with well-controlled HIV

For HIV-infected patients whose disease is well-controlled by modern treatment, the risk of death is not significantly higher than in the general population, according to a study published in AIDS, official journal of the International AIDS Society. AIDS is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

12 Mar 2013

Combining weight loss therapy and CPAP can help reduce blood pressure in OSA patients

Obesity and obstructive sleep apnea (OSA) tend to co-exist and are associated with high blood pressure. The effects of weight loss and continuous positive airway pressure (CPAP), the standard therapy for OSA, on blood pressure have been previously studied individually, but the incremental benefit of combination therapy (weight loss and CPAP therapy) over either therapy alone in obese patients with OSA has been unknown.

12 Mar 2013

Measuring avoidance could predict children's development of anxiety

Children who avoid situations they find scary are likely to have anxiety a Mayo Clinic study of more than 800 children ages 7 to 18 found. The study published this month in Behavior Therapy presents a new method of measuring avoidance behavior in young children.

12 Mar 2013

On and off-pump coronary artery bypass surgery equally safe, effective for older patients

Older patients did as well after undergoing coronary bypass surgery off-pump as they did with the more costly "on-pump" procedure using a heart-lung machine to circulate blood and oxygen through the body during surgery, according to research presented today at the American College of Cardiology's 62nd Annual Scientific Session.

12 Mar 2013

Researchers uncover clear genetic link between fat and bone mass

When it comes to body shape, diet and exercise can only take us so far. Our body shape and geometry are largely determined by genetic factors. Genetics also have an impact on our body composition - including soft fat tissue and hard bone tissue - and can lead to excess fat or osteoporosis.

12 Mar 2013

Therapy News and Research

Burnt-out employees have increased risk of heart disease, researcher finds

RELAX study finds no beneficial effects of erectile dysfunction drug for diastolic heart failure

Restored Hearing to launch clinical trials to find cure for permanent tinnitus

Mini-chromosome maintenance protein can change DNA topology: Study

Cangrelor solidly outperforms clopidogrel during percutaneous coronary intervention

Aliskiren and standard therapy not associated with reduced CV death or HF rehospitalization

Results from Orion Pharma’s ORM-12741 phase IIa study on AD

Addition of niacin to statin does not improve HDL function

NIH-sponsored comparative trial evaluates benefits of combination therapy and monotherapy in MS

Sildenafil does not improve exercise capacity in HF patients with preserved ejection fraction

Nearly two-thirds of women with ovarian cancer do not receive guideline-adherent care

Combination of INF and glatiramer acetate does not reduce MS progression

Sildenafil does not help heart failure patients with preserved ejection fraction

UniStem Day 2013 to take place on Mar. 15

New Sapien XT aortic valve reduces rate of death and strokes

Study: No increase in mortality with well-controlled HIV

Combining weight loss therapy and CPAP can help reduce blood pressure in OSA patients

Measuring avoidance could predict children's development of anxiety

On and off-pump coronary artery bypass surgery equally safe, effective for older patients

Researchers uncover clear genetic link between fat and bone mass

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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