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Gene therapy does not slow or halt progression of cell loss in Leber congenital amaurosis

Independent clinical trials, including one conducted at the Scheie Eye Institute at the Perelman School of Medicine, have reported safety and efficacy for Leber congenital amaurosis (LCA), a congenital form of blindness caused by mutations in a gene (RPE65) required for recycling vitamin A in the retina. Inherited retinal degenerative diseases were previously considered untreatable and incurable.

23 Jan 2013

Study details exactly how Her2 gene promotes progression and spread of breast cancer cells

Research led by Dr. Suresh Alahari, the Fred Brazda Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans and its Stanley S. Scott Cancer Center, details exactly how the Her2 cancer gene promotes the progression and spread of breast cancer cells.

23 Jan 2013

Novel way to engineer specialized immune cells targeted by the AIDS virus

Researchers at the Stanford University School of Medicine have found a novel way to engineer key cells of the immune system so they remain resistant to infection with HIV, the virus that causes AIDS.

23 Jan 2013

Galectin Therapeutics' GR-MD-02 reverses diabetic nephropathy in preclinical study

Galectin Therapeutics, the leading developer of therapeutics that target galectin proteins to treat fibrosis and cancer, today announced new preclinical data on the efficacy of anti-galectin therapy on diabetic kidney disease.

23 Jan 2013

Research on dystrophin gene sequence could lead to treatments for Duchenne muscular dystrophy

Muscular dystrophy is caused by the largest human gene, a complex chemical leviathan that has confounded scientists for decades. Research conducted at the University of Missouri and described this month in the Proceedings of the National Academy of Sciences has identified significant sections of the gene that could provide hope to young patients and families.

23 Jan 2013

SLU team discovers molecular pathway that contributes to triple-negative breast cancer

In research published in the Jan. 17 issue of The Journal of Cell Biology, a team led by Susana Gonzalo, Ph.D., assistant professor of biochemistry and molecular biology at Saint Louis University, has discovered a molecular pathway that contributes to triple-negative breast cancer, an often deadly and treatment resistant form of cancer that tends to strike younger women.

23 Jan 2013

Nationwide Children's to establish EC145 helicopter for neonatal and pediatric transports

Nationwide Children's Hospital is expanding their critical care transport services by establishing a fully dedicated helicopter for neonatal and pediatric transports.

23 Jan 2013

Less is more for emergency department treatment of whiplash

Researchers recommend that patients presenting to emergency departments with acute whiplash should receive usual consultations and a single physiotherapy advice session for persistent symptoms.

22 Jan 2013

Low-income groups slow to seek treatment for stroke

People with lower incomes are less likely to present at a hospital within 3 hours of stroke symptoms and thus have lower rates of thrombolysis therapy or post-stroke care than their more affluent counterparts, according to a retrospective analysis.

22 Jan 2013

Ultrasound strategy excludes DVT in pregnant women

Serial compression ultrasonography with iliac vein visualization can reliably exclude deep vein thrombosis in symptomatic pregnant women, according to results from an 8-year prospective cohort study published in the Canadian Medical Association Journal.

22 Jan 2013

Intelligent algorithms for programming deep brain stimulation in Parkinson’s to be developed by Great Lakes NeuroTechnologies

Great Lakes NeuroTechnologies (GLNT) announced today that they are launching a study to determine the feasibility of using intelligent algorithms to assist with programming deep brain stimulation settings for Parkinson’s disease.

22 Jan 2013

Chronic heart failure treatment, Inspra (eplerenone), accepted for use within NHS Wales

Inspra (eplerenone) has now been accepted by the All Wales Medicines Strategy Group (AWMSG) for use in adult patients with chronic heart failure (CHF) NYHA class II, in combination with standard optimal therapy...

22 Jan 2013

Dutasteride decreases risk of biopsy detectable prostate cancer by 22.8%

The four-year REDUCE (REduction by DUtasteride of prostate Cancer Events) clinical study evaluated prostate cancer risk reduction in men taking dutasteride, a 5-alpha-reductase inhibitor (5ARI) typically used to treat enlarged prostate.

22 Jan 2013

Synthon Biopharmaceuticals announces promising results with its antibody-drug conjugate program

Synthon Biopharmaceuticals, a subsidiary of specialty pharma company Synthon, has reported promising results with its lead program of antibody-drug conjugates (ADCs).

22 Jan 2013

Gene therapy improves vision but does not halt progression of cell loss

22 Jan 2013

Regular aspirin use appears to be associated with increased risk of neovascular AMD

Regular aspirin use appears to be associated with an increased risk of neovascular age-related macular degeneration (AMD), which is a leading cause of blindness in older people, and it appears to be independent of a history of cardiovascular disease and smoking, according to a report published Online First by JAMA Internal Medicine, a JAMA Network publication.

22 Jan 2013

Golden nanoparticle starves cancer cell to death

How do you annihilate lymphoma without using any drugs? Starve it to death by depriving it of what appears to be a favorite food: HDL cholesterol.

21 Jan 2013

Current smokers with HIV more likely to get bacterial pneumonia

Bacterial pneumonia is one of the commonest and most serious infections occurring in people infected with HIV. A metanalysis of cohort and case control studies published in BioMed Central's open access journal BMC Medicine finds that current smokers with HIV were at double the risk of bacterial pneumonia than non-smoking counterparts, but that when people stopped smoking their risk was reduced.

21 Jan 2013

Bevacizumab QoL impact highlighted in ovarian cancer patients

The ICON7 study results suggest that improved progression-free survival with bevacizumab therapy for high-risk ovarian cancer may come at the cost of health-related quality of life.

21 Jan 2013

Early treatment during primary HIV infection shows promise

Two papers in The New England Journal of Medicine suggest that starting antiretroviral treatment early after HIV infection is diagnosed may improve patients’ immune response, boosting the initial recovery of the immune system and delaying progression of the disease.

21 Jan 2013

Therapy News and Research

Gene therapy does not slow or halt progression of cell loss in Leber congenital amaurosis

Study details exactly how Her2 gene promotes progression and spread of breast cancer cells

Novel way to engineer specialized immune cells targeted by the AIDS virus

Galectin Therapeutics' GR-MD-02 reverses diabetic nephropathy in preclinical study

Research on dystrophin gene sequence could lead to treatments for Duchenne muscular dystrophy

SLU team discovers molecular pathway that contributes to triple-negative breast cancer

Nationwide Children's to establish EC145 helicopter for neonatal and pediatric transports

Less is more for emergency department treatment of whiplash

Low-income groups slow to seek treatment for stroke

Ultrasound strategy excludes DVT in pregnant women

Intelligent algorithms for programming deep brain stimulation in Parkinson’s to be developed by Great Lakes NeuroTechnologies

Chronic heart failure treatment, Inspra (eplerenone), accepted for use within NHS Wales

Dutasteride decreases risk of biopsy detectable prostate cancer by 22.8%

Synthon Biopharmaceuticals announces promising results with its antibody-drug conjugate program

Gene therapy improves vision but does not halt progression of cell loss

Regular aspirin use appears to be associated with increased risk of neovascular AMD

Golden nanoparticle starves cancer cell to death

Current smokers with HIV more likely to get bacterial pneumonia

Bevacizumab QoL impact highlighted in ovarian cancer patients

Early treatment during primary HIV infection shows promise

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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