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Study refocuses on how neuroblastoma tumors evolve in response to medicine and other factors

An extensive genomic study of the childhood cancer neuroblastoma reinforces the challenges in treating the most aggressive forms of this disease. Contrary to expectations, the scientists found relatively few recurrent gene mutations—mutations that would suggest new targets for neuroblastoma treatment. Instead, say the researchers, they have now refocused on how neuroblastoma tumors evolve in response to medicine and other factors.

21 Jan 2013

FDA to step up evaluation of metal hip implants, other devices

The Food and Drug Administration is studying whether several medical devices already on the market, such as electroconvulsive therapy devices for depression and emergency defibrillators, require additional evidence to prove they're safe.

19 Jan 2013

EMA adopts positive opinion for Pfizer’s bosutinib conditional approval in the EU

Pfizer Inc. announced today that the Committee for Medicinal Products for Human Use of the European Medicines Agency has adopted a positive opinion regarding the conditional marketing authorization of bosutinib in the European Union for the treatment of adult patients with chronic phase (CP), accelerated phase (AP), and blast phase (BP) Philadelphia chromosome positive chronic myelogenous leukemia previously treated with one or more tyrosine kinase inhibitor(s) (TKIs) and for whom imatinib, nilotinib and dasatinib are not considered appropriate treatment options.

19 Jan 2013

Cancer Targets & Therapeutics Conference to take place from Feb. 25-26 in Las Vegas

With the rapid progression of molecular biology and genetics, and the subsequent emergence of many new targets, emerging targets & therapeutics provides new opportunities for the prevention and treatment of several major disease systems.

19 Jan 2013

CRF to sponsor 8th International Conference on Cell Therapy for Cardiovascular Disease

The final agenda for the Eighth International Conference on Cell Therapy for Cardiovascular Disease, sponsored by the Cardiovascular Research Foundation, is now available online.

19 Jan 2013

ECLS system supports flu patients in their recovery from severe respiratory problems

In recent weeks the intensive critical care units at University Health Network's Toronto General Hospital have used Extra Corporeal Lung Support (ECLS) to support five influenza (flu) patients in their recovery from severe respiratory problems.

19 Jan 2013

New math model may help predict colon cancer resistance to chemotherapy

Scientists may be able to better predict which patients with colorectal cancer will respond to chemotherapy using a new mathematical model that measures the amount of stress required for a cancer cell to die without harming healthy tissue. The results of this study are published in Cancer Research, a journal of the American Association for Cancer Research.

19 Jan 2013

New method can visualize aging and tumor growth in real-time

In a study published in the January 18 issue of Cell, researchers from the University of North Carolina Lineberger Comprehensive Cancer Center have developed a new method to visualize aging and tumor growth in mice using a gene closely linked to these processes.

18 Jan 2013

$ADT increases risk of fracture incidence after treatment completion in men with prostate cancer$

ADT increases risk of fracture incidence after treatment completion in men with prostate cancer

In what is believed to be the first study to describe the impact on men with a 'high' risk of bone fracture who are receiving long-term androgen deprivation therapy (ADT) for prostate cancer, new research from The Cancer Institute of New Jersey shows this population to have a higher fracture incidence following treatment completion.

18 Jan 2013

Researchers disagree over ethics of HIV treatment clinical trial in Africa, Nature reports

Nature reports how "a potential breakthrough in the quest to prevent HIV and AIDS has collided with sensitivities about testing expensive drugs in poor parts of the world."

18 Jan 2013

Sabutoclax appears to selectively target leukemia stem cells that are responsible for relapses

Researchers at the University of California, San Diego School of Medicine have discovered that hard-to-reach, drug-resistant leukemia stem cells (LSCs) that overexpress multiple pro-survival protein forms are sensitive - and thus vulnerable - to a novel cancer stem cell-targeting drug currently under development.

18 Jan 2013

Children's Oakland recruits patients for deferiprone clinical trial to treat PKAN

A groundbreaking, international clinical trial of an iron chelation drug, deferiprone, to treat the rare and devastating neurodegenerative disease, pantothenate kinase-associated neurodegeneration (PKAN), began last month at the trial's only North American site, Children's Hospital & Research Center Oakland.

17 Jan 2013

Donor feces more effective than antibiotic for C. difficile infection

Treatment of recurrent Clostridium difficile infection with donor feces infusion is significantly more effective than conventional vancomycin therapy, show results published in The New England Journal of Medicine.

17 Jan 2013

Hypercoagulable markers identified in upper arm thrombosis patients

Coagulation tests are warranted in young women undergoing surgery for subclavian vein thrombosis, especially patients with Paget-Schroetter syndrome unrelated to physical activity, say US clinicians.

17 Jan 2013

True extent of life-support buy-in revealed

Many surgeons contract informally with patients preoperatively about the use of postoperative life support, report researchers.

17 Jan 2013

Potential stem cell therapy for Duchenne’s

Researchers have found that injecting aorta-derived stem cells into the hearts of dystrophin-deficient mice prevents the onset of dilated cardiomyopathy, raising hopes of a potential new treatment approach to prevent or reverse the condition in human Duchenne muscular dystrophy.

17 Jan 2013

FDA clears Sanovas’ Vas Zeppelin Smart Catheter to treat chronic pulmonary diseases, lung cancer

Sanovas Inc., a life science technology company developing and commercializing the next-generation of micro-invasive diagnostics, devices and drug delivery technologies, announced today that it has filed with the U.S. Food and Drug Administration for clearance of the company's Vas Zeppelin Smart Catheter for the treatment of chronic pulmonary diseases and lung cancer.

17 Jan 2013

Scientists identify new mechanism for schistosomiasis-bladder cancer connection

About 200 million people across 75 of the poorest countries in the world are now infected by the blood parasite Schistosoma haematobium (S. haematobium). The infection causes severe urogenital disease, but also causes bladder cancer in a number of patients and why this occurs is not clear.

17 Jan 2013

Positive gene therapy results in large mammals of Duchenne muscular dystrophy

Usually, results from a new study help scientists inch their way toward an answer whether they are battling a health problem or are on the verge of a technological breakthrough. Once in a while, those results give them a giant leap forward. In a preliminary study in a canine model of Duchenne muscular dystrophy (DMD), University of Missouri scientists showed exactly such a leap using gene therapy to treat muscular dystrophy.

17 Jan 2013

FDA approves St. Jude Medical’s Merlin.net Patient Care Network

St. Jude Medical, Inc., a global medical device company, today announced U.S. Food and Drug Administration (FDA) approval of the next-generation Merlin.net Patient Care Network (PCN), a secure, Internet-based remote care system for patients with implanted medical devices.

17 Jan 2013

Therapy News and Research

Study refocuses on how neuroblastoma tumors evolve in response to medicine and other factors

FDA to step up evaluation of metal hip implants, other devices

EMA adopts positive opinion for Pfizer’s bosutinib conditional approval in the EU

Cancer Targets & Therapeutics Conference to take place from Feb. 25-26 in Las Vegas

CRF to sponsor 8th International Conference on Cell Therapy for Cardiovascular Disease

ECLS system supports flu patients in their recovery from severe respiratory problems

New math model may help predict colon cancer resistance to chemotherapy

New method can visualize aging and tumor growth in real-time

ADT increases risk of fracture incidence after treatment completion in men with prostate cancer

Researchers disagree over ethics of HIV treatment clinical trial in Africa, Nature reports

Sabutoclax appears to selectively target leukemia stem cells that are responsible for relapses

Children's Oakland recruits patients for deferiprone clinical trial to treat PKAN

Donor feces more effective than antibiotic for C. difficile infection

Hypercoagulable markers identified in upper arm thrombosis patients

True extent of life-support buy-in revealed

Potential stem cell therapy for Duchenne’s

FDA clears Sanovas’ Vas Zeppelin Smart Catheter to treat chronic pulmonary diseases, lung cancer

Scientists identify new mechanism for schistosomiasis-bladder cancer connection

Positive gene therapy results in large mammals of Duchenne muscular dystrophy

FDA approves St. Jude Medical’s Merlin.net Patient Care Network

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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