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Osteopontin plays a role in X-linked hypophosphatemia

Diagnosed in toddlers, X-linked hypophosphatemia (XLH) is the most common form of heritable rickets, in which soft bones bend and deform, and tooth abscesses develop because infections penetrate soft teeth that are not properly calcified. Researchers at McGill University and the Federal University of Sao Paulo have identified that osteopontin, a major bone and tooth substrate protein, plays a role in XLH. Their discovery may pave the way to effectively treating this rare disease.

21 Feb 2013

New bio-mimicking therapeutics could help treat skin wounds

In "before" and "after" photos from advertisements for wound-healing ointments, bandages and antibiotic creams, we see an injury transformed from an inflamed red gash to smooth and flawless skin. What we don't appreciate is the vital role that our own natural biomolecules play in the healing process, including their contribution to the growth of new cells and the development of new blood vessels that provide nutrients to those cells.

21 Feb 2013

GCP could help lengthen life expectancy of certain prostate cancer patients

A natural, nontoxic product called genistein-combined polysaccharide, or GCP, which is commercially available in health stores, could help lengthen the life expectancy of certain prostate cancer patients, UC Davis researchers have found.

21 Feb 2013

Veterans diagnosed with reflux issues often start on high doses of drugs, rarely stop therapy

U.S. veterans diagnosed with gastroesophageal reflux disease (GERD) are frequently prescribed doses of proton pump inhibitors (PPIs), such as omeprazole (commonly known by brand names such as Prilosec), that are much higher than recommended --- and they are kept on the drug far too long, according to a new Northwestern Medicine- study.

21 Feb 2013

Immune Pharmaceuticals commences Phase II study with bertilimumab to treat ulcerative colitis

Immune Pharmaceuticals Ltd., a privately held Israeli company, and EpiCept Corporation announced today that Immune is initiating, following authorization from Israeli health authorities, a Phase II double-blind placebo controlled study with its lead drug, bertilimumab, in patients with moderate-to-severe ulcerative colitis.

21 Feb 2013

Muhammad Ali Parkinson Center in Phoenix launches new clinic

The Muhammad Ali Parkinson Center in Phoenix has launched a new clinic aimed at streamlining the process for the growing number of patients who are potential candidates for Deep Brain Stimulation.

20 Feb 2013

UCB seeks FDA and EMA marketing authorization for Cimzia to treat active psoriatic arthritis

UCB announced today two new regulatory filings with the US Food and Drug Administration (FDA) and with the European Medicines Agency (EMA) to extend the marketing authorization for Cimzia (certolizumab pegol) for the treatment of adult patients with active psoriatic arthritis (PsA) and for adult patients with active axial spondyloarthritis (axSpA).

20 Feb 2013

Expert to explain how extremely stable gold nanoparticles can be used in medicine

A nanoscale science expert will explain how extremely stable gold nanoparticles can be used in medicine. Professor Mathias Brust, of the University of Liverpool, will give his lecture Monolayer Protected Clusters of Gold: Building Blocks, Functional Materials, Macromolecules, Biomedical Tools and more at the University of Leicester on Thursday, February 21.

20 Feb 2013

Physiotherapy aids defecation in constipated children

Physiotherapy may be an effective complementary therapy to laxatives for treating constipation in children, research indicates.

20 Feb 2013

COX-2 inhibitor extends sunitinib activity in renal cell carcinoma

The effectiveness of sunitinib for the treatment of renal cell carcinoma could be enhanced with the addition of a cyclooxygenase-2 inhibitor, study findings show.

20 Feb 2013

Metastatic tumors best for sunitinib response evaluation in mRCC

When evaluating treatment response in non-nephrectomized patients with metastatic renal cell carcinoma, the primary lesion does not have to be selected as the target lesion, researchers report.

20 Feb 2013

AMD risk alleles fail to predict treatment response

The major risk alleles that influence the development of age-related macular degeneration do not predict response to therapy for the condition, a substudy of the CATT trial indicates.

20 Feb 2013

Misconduct biased fluid resuscitation studies

There are “serious safety concerns” associated with the use of hydroxyethyl starch for fluid resuscitation in critically ill patients, say the authors of a meta-analysis in JAMA.

20 Feb 2013

‘Liver first’ approach first choice for metastatic rectal cancer

Using the “liver first” approach to treat locally advanced rectal cancer and synchronous liver metastases allows nearly three-quarters of patients to receive optimal neoadjuvant therapy and resection for both their primary tumor and metastases, researchers report.

20 Feb 2013

Antibody-drug conjugates (ADCs): an interview with Dr Marco Timmers, CSO at Synthon Biopharmaceuticals

ADCs are used for a new type of targeted therapy that consists of a specific anti-cancer antibody or antibody fragment linked to a potent anti-cancer therapeutic.

20 Feb 2013

KSU faculty members help children with auditory processing disorder receive better treatment

Several Kansas State University faculty members are helping children with auditory processing disorder receive better treatment.

20 Feb 2013

Medical nutrition therapy can play an important role in acne treatment

A study published in the Journal of the Academy of Nutrition and Dietetics has determined that there is increasing evidence of a connection between diet and acne, particularly from high glycemic load diets and dairy products, and that medical nutrition therapy (MNT) can play an important role in acne treatment.

20 Feb 2013

Study reveals rare look into success of substance abuse treatment programs for African-Americans

New research out of the University of Cincinnati reveals a relatively rare look into the success of substance abuse treatment programs for African-Americans. Researchers report that self-motivation could be an important consideration into deciding on the most effective treatment strategy.

20 Feb 2013

Study may help design better DAA drug cocktails to treat HCV

Hepatitis C virus (HCV) infection affects about 4 million in the United States and is the primary cause of liver cirrhosis and liver cancer. Current therapy against HCV is suboptimal. Daclatasvir, a direct acting antiviral (DAA) agent in development for the treatment of HCV, targets one of the HCV proteins (i.e., NS5A) and causes the fastest viral decline (within 12 hours of treatment) ever seen with anti-HCV drugs.

20 Feb 2013

TIR-199 shows promise in fighting renal cancer

Chemists at the University of California, Riverside have developed a compound that holds much promise in the laboratory in fighting renal (kidney) cancer.

20 Feb 2013

Therapy News and Research

Osteopontin plays a role in X-linked hypophosphatemia

New bio-mimicking therapeutics could help treat skin wounds

GCP could help lengthen life expectancy of certain prostate cancer patients

Veterans diagnosed with reflux issues often start on high doses of drugs, rarely stop therapy

Immune Pharmaceuticals commences Phase II study with bertilimumab to treat ulcerative colitis

Muhammad Ali Parkinson Center in Phoenix launches new clinic

UCB seeks FDA and EMA marketing authorization for Cimzia to treat active psoriatic arthritis

Expert to explain how extremely stable gold nanoparticles can be used in medicine

Physiotherapy aids defecation in constipated children

COX-2 inhibitor extends sunitinib activity in renal cell carcinoma

Metastatic tumors best for sunitinib response evaluation in mRCC

AMD risk alleles fail to predict treatment response

Misconduct biased fluid resuscitation studies

‘Liver first’ approach first choice for metastatic rectal cancer

Antibody-drug conjugates (ADCs): an interview with Dr Marco Timmers, CSO at Synthon Biopharmaceuticals

KSU faculty members help children with auditory processing disorder receive better treatment

Medical nutrition therapy can play an important role in acne treatment

Study reveals rare look into success of substance abuse treatment programs for African-Americans

Study may help design better DAA drug cocktails to treat HCV

TIR-199 shows promise in fighting renal cancer

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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