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Tug of war between Hsp70 and 90 determines how much the body makes of superoxide

Two proteins are in a tug of war that determines how much the body makes of superoxide, a highly reactive and potentially destructive product of oxygen that's dramatically elevated in cardiovascular disease, researchers report.

16 Nov 2012

CLR01 effectively inhibits synaptotoxicity in mice with Alzheimer's

Last March, researchers at UCLA reported the development of a molecular compound called CLR01 that prevented toxic proteins associated with Parkinson's disease from binding together and killing the brain's neurons.

16 Nov 2012

New insights into how MSCs ‘traffic’ from the circulation into tissues

Mesenchymal stem cells (MSCs), are a newly emerging cellular therapy being tested in approximately 250 clinical trials worldwide to help repair damaged tissues, such as injured heart muscle following a heart attack. The problem is that when culture-expanded MSCs are injected into the circulation, they have trouble gaining access to the inflamed tissues-exactly where their help is needed.

16 Nov 2012

New AAN book for people with primary and metastatic brain tumors

It is estimated that every 30 minutes, someone is diagnosed with brain cancer. Published in conjunction with the American Academy of Neurology as part of the Neurology Now Books series, NAVIGATING LIFE WITH A BRAIN TUMOR provides readily accessible information and encouragement for the thousands of people living with primary and metastatic brain tumors.

16 Nov 2012

Researchers develop catheter that can perform triple-duty during cardiac ablation surgery

Researchers at the McCormick School of Engineering are part of a team that has used stretchable electronics to create a multipurpose medical catheter that can both monitor heart functions and perform corrections on heart tissue during surgery.

16 Nov 2012

Study looks at health outcomes of kidney transplant recipients with low donor-specific antibodies

Kidney transplant recipients who have even very low levels of preformed antibodies directed against a donated kidney have a significantly increased risk of organ rejection and kidney failure, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

16 Nov 2012

Tanshinones protect against sepsis: Study

Researchers at The Feinstein Institute for Medical Research have discovered that tanshinones, which come from the plant Danshen and are highly valued in Chinese traditional medicine, protect against the life-threatening condition sepsis. The findings are published in the December issue of Biochemical Pharmacology.

16 Nov 2012

Cook receives FDA approval for Zilver PTX Drug-Eluting Peripheral Stent to treat PAD

The U.S. Food and Drug Administration approved the Zilver PTX Drug-Eluting Peripheral Stent (Zilver PTX Stent), the first drug-eluting stent indicated to re-open a particular artery in the thigh (femoropopliteal artery) when narrowed or blocked as a result of peripheral artery disease (PAD).

15 Nov 2012

Gene therapy shows promise against dry mouth in cancer patients

Injecting an adenoviral vector encoding human aquaporin-1 into the parotid glands of head and neck cancer survivors improves their symptoms of dry mouth induced by radiation therapy, show study results.

15 Nov 2012

Deep-brain stimulation effects sustained in dystonia

Improvements in dystonia achieved with deep-brain stimulation are usually sustained for at least 5 years, shows follow up of a randomized trial.

15 Nov 2012

Positive preliminary results from ImmunoPulse Phase II trial in metastatic melanoma

OncoSec Medical Inc., a company developing its advanced-stage ImmunoPulse DNA-based immunotherapy and NeoPulse therapy to treat solid tumors, announces positive preliminary results from a Phase II trial investigating the use of ImmunoPulse in metastatic melanoma patients at the 6th World Meeting of Interdisciplinary Melanoma Skin Cancer Centres & 8th EADO Congress.

15 Nov 2012

Breakthrough treatment for survivors of traumatic brain injury

The first treatment breakthrough of its kind for survivors of traumatic brain injury (TBI) or stroke will be published in the December 1 issue of the journal CNS Drugs, with an accompanying editorial.

15 Nov 2012

Roundup: Disparity in states' fiscal health; Ark. Medicaid shortfall threatens care; Mich. Blue Cross pushes to become nonprofit

Factors such as growing unfunded pension liabilities and burgeoning fixed costs related to programs like Medicaid are weighing down weaker states, while stronger states are benefiting from improved business conditions and strong employment growth, he said. A closer look at some specific metrics shows this fiscal disparity.

15 Nov 2012

Study on effect of glucose on cancer growth in mice

An animal study conducted by researchers at Georgetown Lombardi Comprehensive Cancer Center raises questions about the consequences of diet - specifically glucose, the plant-based sugar that fuels cell life - on increased activity of an oncogene that drives tumor growth.

15 Nov 2012

Myasthenia gravis therapies: an interview with Professor Daniel Drachman

Myasthenia gravis (MG) is an autoimmune disease that produces weakness and fatiguability of muscles. It affects between 1 and 7 people per 10,000, according to the best statistics.

15 Nov 2012

Trastuzumab increases risk of heart failure in older women with breast cancer

Heart failure is a relatively common complication in older women with breast cancer, but the risk is even higher in those patients treated with adjuvant trastuzumab (Herceptin-), Yale School of Medicine researchers report in the current issue of the Journal of the American College of Cardiology.

15 Nov 2012

Pharmaceutical compounding problems spread under lax regulation

News outlets report that congressional oversight was lacking and the Boston Globe uncovers documents about the company that started the meningitis outbreak.

15 Nov 2012

Irregular sleep patterns may trigger schizophrenia symptoms

Neuroscientists studying the link between poor sleep and schizophrenia have found that irregular sleep patterns and desynchronised brain activity during sleep could trigger some of the disease's symptoms. The findings, published in the journal Neuron, suggest that these prolonged disturbances might be a cause and not just a consequence of the disorder's debilitating effects.

15 Nov 2012

ALN RNAi therapeutic program represents novel approach for treatment of AAT deficiency

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today that it has presented new pre-clinical data with an RNAi therapeutic targeting alpha-1 antitrypsin (AAT) for the treatment of liver disease associated with AAT deficiency. These data were presented at the 63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD, "The Liver Meeting") held November 9-13, 2012 in Boston.

15 Nov 2012

Age at onset of first menstrual cycle associated with increased BMI, obesity in adulthood

Age at onset of menarche (first menstrual cycle) is associated with increased body mass index (BMI), waist circumference, and overall obesity in adulthood, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

15 Nov 2012

Therapy News and Research

Tug of war between Hsp70 and 90 determines how much the body makes of superoxide

CLR01 effectively inhibits synaptotoxicity in mice with Alzheimer's

New insights into how MSCs ‘traffic’ from the circulation into tissues

New AAN book for people with primary and metastatic brain tumors

Researchers develop catheter that can perform triple-duty during cardiac ablation surgery

Study looks at health outcomes of kidney transplant recipients with low donor-specific antibodies

Tanshinones protect against sepsis: Study

Cook receives FDA approval for Zilver PTX Drug-Eluting Peripheral Stent to treat PAD

Gene therapy shows promise against dry mouth in cancer patients

Deep-brain stimulation effects sustained in dystonia

Positive preliminary results from ImmunoPulse Phase II trial in metastatic melanoma

Breakthrough treatment for survivors of traumatic brain injury

Roundup: Disparity in states' fiscal health; Ark. Medicaid shortfall threatens care; Mich. Blue Cross pushes to become nonprofit

Study on effect of glucose on cancer growth in mice

Myasthenia gravis therapies: an interview with Professor Daniel Drachman

Trastuzumab increases risk of heart failure in older women with breast cancer

Pharmaceutical compounding problems spread under lax regulation

Irregular sleep patterns may trigger schizophrenia symptoms

ALN RNAi therapeutic program represents novel approach for treatment of AAT deficiency

Age at onset of first menstrual cycle associated with increased BMI, obesity in adulthood

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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