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Study finds new signaling pathway involved in development of chronic inflammation of brain cells

The number of Alzheimer's patients will continue to dramatically increase in the next several decades. Various teams of researchers worldwide are feverishly investigating precisely how the illness develops. A

20 Dec 2012

Merck’s TREDAPTIVE clinical study on high-risk CVD patients does not meet primary endpoint

Merck, known outside the United States and Canada as MSD, today announced that the HPS2-THRIVE (Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events) study of TREDAPTIVE(extended-release niacin/laropiprant) did not meet its primary endpoint.

20 Dec 2012

Biotest receives FDA approval for BIVIGAM to treat primary humoral immunodeficiency

Biotest AG announced today that Biotest Pharmaceuticals Corporation received approval for BIVIGAM for the treatment of patients with Primary Humoral Immunodeficiency (PI) from the U.S. Food and Drug Administration (FDA).

20 Dec 2012

Disparities in HIV care in Ontario

Researchers have found significant disparities in hospital admission rates for certain groups of individuals living with HIV in Ontario, Canada.

20 Dec 2012

CBT boosts response in medication-resistant depression

Patients with depression who have not responded to pharmacologic treatment should be offered cognitive behavioral therapy, suggest the results of a randomized trial conducted in a primary care setting.

20 Dec 2012

Scientists uncover TDP-43 protein as possible target for treatment of ALS, FTD

Neuroscientists at Georgetown University Medical Center say they have new evidence that challenges scientific dogma involving two fatal neurodegenerative diseases - amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD) - and, in the process, have uncovered a possible therapeutic target as a novel strategy to treat both disorders.

20 Dec 2012

Investigators report non-coding miRNAs as appealing biomarkers for cancer malignancy

As many as 50 percent of all human protein-coding genes are regulated by microRNA (miRNA) molecules. While some miRNAs impact onset and progression of cancer, others can actually suppress the development of malignant tumors and are useful in cancer therapy. They can also serve as potential biomarkers for early cancer detection. In a new issue of Cancer Biomarkers, investigators report on non-coding miRNAs as appealing biomarkers for malignancy.

20 Dec 2012

AAV-based gene therapy cocktail may help extend lives of children with Canavan disease

Results of a clinical trial that began in 2001 show that a gene therapy cocktail conveyed into the brain by a molecular special delivery vehicle may help extend the lives of children with Canavan disease, a rare and fatal neurodegenerative disorder.

20 Dec 2012

Personalized rectal cancer therapy shows promise

Personalized chemotherapy for rectal cancer results in high rates of pathologic response, indicate the results of a pilot study.

19 Dec 2012

Partners should be involved in speech therapy

The partners of individuals who stutter should be involved in stuttering treatment, researchers advise.

19 Dec 2012

Umbilical cord stem cell therapy shows promise in infant BPD

Researchers have successfully used human umbilical cord stem cells to partially prevent damage and restore lung structure and function in an experimental animal model of bronchopulmonary dysplasia.

19 Dec 2012

Findings emphasize importance of counseling HIV patients on smoking cessation

Among HIV patients receiving well-organized care with free access to antiretroviral therapy, those who smoke lose more years of life to smoking than to HIV, according to a Danish study published in Clinical Infectious Diseases and available online. The findings highlight the importance of smoking cessation efforts in the long-term, integrated care of patients infected with HIV.

19 Dec 2012

Ion channel acts as powerful ‘brake’ after epileptic seizures

Given that epilepsy impacts more than 2 million Americans, there is a pressing need for new therapies to prevent this disabling neurological disorder. New findings from the neuroscience laboratory of Mark S. Shapiro, Ph.D., at The University of Texas Health Science Center at San Antonio, published Dec. 20 in the high-impact scientific journal, Neuron, may provide hope.

19 Dec 2012

Risk Benefit kit to empower patients with critical decision making tools

The American Autoimmune Related Diseases Association (AARDA) conducted a study to determine what factors patients took into consideration when deciding to adhere or not adhere to new treatment as prescribed by their physicians.

19 Dec 2012

Festive season can trigger new cases of tinnitus

On the run-up to New Year, most of us stock-up with remedies for a sore head, bloated tummy, itching eyes and a bout of flu. But have you ever stopped to consider your hearing?

19 Dec 2012

University of Maryland, Baltimore hosts first national conference on oral and systemic health

By hosting the first national conference on oral and systemic health in Baltimore on Dec. 10, the University of Maryland, Baltimore (UMB) took another major step toward true interprofessional health care education, says Jay A. Perman, MD, president of the University.

19 Dec 2012

Georgia State researcher discover new process to make one-time flu vaccine

A new process to make a one-time, universal influenza vaccine has been discovered by a researcher at Georgia State University's Center for Inflammation, Immunity and Infection and his partners.

19 Dec 2012

Tumor cells manipulate unfolded protein response

Researchers at the University of California, San Diego School of Medicine report that tumor cells use stress signals to subvert responding immune cells, exploiting them to actually boost conditions beneficial to cancer growth.

19 Dec 2012

Infectex initiates enrollment in SQ109 Phase IIb-III trial for MDR-TB

Infectex, a Russian biotech company in Maxwell Biotech Venture Fund's portfolio, announced today enrollment of the first patients in its Phase IIb-III clinical trial of SQ109 for MDR-TB. Infectex was founded in 2011 to develop and commercialize innovative products for the treatment of TB.

19 Dec 2012

Riverside Methodist Hospital treats first PAD patient with Cook Medical's Zilver PTX device

Just weeks after the Food and Drug Administration (FDA) approved Cook Medical's Zilver PTX Drug-Eluting Peripheral Stent, Riverside Methodist Hospital in Columbus, Ohio, has treated the first patient with the device as part of Cook's U.S. commercial launch.

19 Dec 2012

Therapy News and Research

Study finds new signaling pathway involved in development of chronic inflammation of brain cells

Merck’s TREDAPTIVE clinical study on high-risk CVD patients does not meet primary endpoint

Biotest receives FDA approval for BIVIGAM to treat primary humoral immunodeficiency

Disparities in HIV care in Ontario

CBT boosts response in medication-resistant depression

Scientists uncover TDP-43 protein as possible target for treatment of ALS, FTD

Investigators report non-coding miRNAs as appealing biomarkers for cancer malignancy

AAV-based gene therapy cocktail may help extend lives of children with Canavan disease

Personalized rectal cancer therapy shows promise

Partners should be involved in speech therapy

Umbilical cord stem cell therapy shows promise in infant BPD

Findings emphasize importance of counseling HIV patients on smoking cessation

Ion channel acts as powerful ‘brake’ after epileptic seizures

Risk Benefit kit to empower patients with critical decision making tools

Festive season can trigger new cases of tinnitus

University of Maryland, Baltimore hosts first national conference on oral and systemic health

Georgia State researcher discover new process to make one-time flu vaccine

Tumor cells manipulate unfolded protein response

Infectex initiates enrollment in SQ109 Phase IIb-III trial for MDR-TB

Riverside Methodist Hospital treats first PAD patient with Cook Medical's Zilver PTX device

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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