Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Study shows how copper boosts pig growth

Pigs have better feed conversion rates with copper in their diets, but until now, scientists didn't fully understand why.

27 Mar 2020

Roscovitine enhances nuclear enrichment of traditionally cytoplasmic signaling molecules

Oncotarget Volume 11, Issue 12 reported that using the HL-60 human non-APL AML model where ATRA causes nuclear enrichment of c-Raf that drives differentiation/G0-arrest, the research team now observe that roscovitine enhanced nuclear enrichment of certain traditionally cytoplasmic signaling molecules and enhanced differentiation and cell cycle arrest.

26 Mar 2020

Jumping genes help make functional brain cells in a lab dish

The process of making functional brain cells in a lab dish requires the precise activation of selfish genetic elements known as LINE-1 (L1) retrotransposons.

26 Mar 2020

Overexpression of hPCL3S could contribute to tumor progression in prostate cancer

The cover for issue 12 of Oncotarget features Figure 11, "Global analyses of the RNA-Seq data of LNCaP empty vector and LNCaP cells overexpressing hPCL3S (Clone 12)" by Abdelfettah, et al.

25 Mar 2020

YAP signal pathway plays a vital role in the onset of head-and-neck cancer

Joint research between Kobe University and National Hospital Organization Kyushu Cancer Center has revealed that mice with mutations in the YAP signal pathway develop head-and-neck cancer over an extremely short period of time (world's fastest cancer onset mouse model), indicating that this pathway plays a crucial role in the onset of these cancers.

25 Mar 2020

Study explores genetic mechanisms underlying resistance to leishmaniasis

In an article published in Scientific Reports, researchers affiliated with the University of São Paulo in Brazil describe experiments performed with mice that show how genetic factors can determine whether an individual is susceptible or resistant to leishmaniasis.

24 Mar 2020

Research reveals important mechanism in the repair of DNA double-strand breaks

Scientists have revealed an important mechanism in the repair of DNA double-strand breaks, according to new research published today in eLife.

24 Mar 2020

Researchers rejuvenate aged human cells with stem cell technology

Scientists have used stem cell technology to force old human cells to rejuvenate, reversing the impact that aging has on cells.

24 Mar 2020

Old human cells regain youthful strength after rejuvenating protein treatment, study finds

Old human cells return to a more youthful and vigorous state after being induced to briefly express a panel of proteins involved in embryonic development, according to a new study by researchers at the Stanford University School of Medicine.

24 Mar 2020

OncoMX knowledgebase improves exploration of cancer biomarkers and related evidence

The OncoMX knowledgebase will improve the exploration and research of cancer biomarkers in the context of related evidence, according to a recent article from the George Washington University.

23 Mar 2020

Fatty acid-binding protein 4 plays an important role in kidney stone formation

Kidney stone disease has a high prevalence worldwide, ranging up to 13% in North America, 9% in Europe, and 5% in Asia. They are painful for patients, often lead to surgery, and impart a significant economic impact.

23 Mar 2020

Melinjo seed extract may improve obesity and diabetes

In Southeast Asia, the fruit, flowers, and leaves of Indonesia's "Melinjo" tree are traditional foods.

23 Mar 2020

Discovery shows a novel opportunity for DOT1L inhibitors in cancer treatment

Oncotarget Volume 11, Issue 11 reported that in order to understand the molecular mechanism of the dependency in MM, the research team examined gene expression changes upon DOT1L inhibition in sensitive and insensitive cell lines and discovered that genes belonging to the endoplasmic reticulum stress pathway and protein synthesis machinery were specifically suppressed in sensitive cells.

22 Mar 2020

Researcher working to measure gene expression in blood of patients treated for opioid use disorder

MingKuan Lin, Research Assistant Professor, INOVA Neuroscience, School of Systems Biology, is working to measure gene expression levels in blood from patients undergoing treatment with buprenorphine for opioid use disorder.

22 Mar 2020

CNIC scientists identify inflammatory regulatory circuit controlled by endothelial cells in the eye

Researchers at the Centro Nacional de Investigaciones Cardiovasculares, working with an international network of scientists, have identified an inflammatory regulatory circuit in the eye controlled by a subtype of endothelial cells, the cells that line the interior of blood vessels.

21 Mar 2020

Researchers discover why some prostate cancers are more aggressive

Researchers at the University of East Anglia have discovered why some prostate cancers are more aggressive, spread to different parts of the body, and ultimately cause death.

20 Mar 2020

Study reveals major changes that occur in mammalian skin cells during wound healing

A team of University of California, Irvine researchers have published the first comprehensive overview of the major changes that occur in mammalian skin cells as they prepare to heal wounds.

19 Mar 2020

Diet affects sperm and the health of offspring

A new study published in the journal Molecular Cell, in March 2020, reports that parental diet is a crucial factor in the future metabolic health of the offspring.

19 Mar 2020

Researchers uncover molecular events underlying paternal diet-induced metabolic disorders in children

When parents eat low-protein or high-fat diets it can lead to metabolic disorders in their adult offspring. Now, an international team led by researchers at the RIKEN Cluster for Pioneering Research have identified a key player and the molecular events underlying this phenomenon in mice.

19 Mar 2020

Bacteria-trapping protein may contribute to breast cancer metastasis

The protein peptidyl arginine deiminase 4 (PAD4), which enables some immune cells to trap bacteria, promoted breast cancer metastasis in mice when expressed in cancer cells, according to data published in Molecular Cancer Research, a journal of the American Association for Cancer Research.

19 Mar 2020