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Phase 3 study of INLYTA fails to meet primary endpoint in treatment-naïve patients with RCC

Pfizer Inc. announced today that a Phase 3 study of INLYTA (axitinib) did not meet its primary endpoint of demonstrating statistically significantly longer progression-free survival, versus sorafenib, in treatment-naïve patients with advanced renal cell carcinoma.

18 Oct 2012

Chloride-restrictive intravenous fluids reduce risk for kidney injury

The restrictive use of chloride in intravenous fluids reduces the risk for acute kidney injury and renal replacement therapy, research shows.

18 Oct 2012

Attachment and relationship problems in adolescents with anxiety

Adolescents with anxiety disorders have greater attachment disorganization and higher levels of dysfunction in peer relationships compared with individuals without an Axis I diagnosis, US study findings indicate.

18 Oct 2012

Gingival crevicular fluid predicts periodontal attachment loss

Analysis of gingival crevicular fluid using mass spectrometry could be used to predict sites of periodontal attachment loss in individuals undergoing maintenance therapy for periodontitis, report researchers.

18 Oct 2012

Pain relief from palliative RT for bone metastases improves QoL

Cancer patients who experience pain relief after palliative radiation therapy for bone metastases report a better quality of life on specific bone metastases measures than their peers who do not respond to treatment, show study results.

18 Oct 2012

Nonmotor symptoms common in early-stage PD

Nonmotor symptoms occur in nearly all individuals with Parkinson’s disease, Italian study results suggest.

17 Oct 2012

Botulinum treatment benefits in BPH maybe down to placebo effect

Treatment with botulinum toxin has proved no more effective than placebo at reducing symptoms in men with lower urinary tract symptoms due to benign prostate hyperplasia, show study findings.

17 Oct 2012

Quitting smoking may improve HRQoL in advanced lung cancer

The health-related quality of life of patients with advanced-stage lung cancer is worsened if they smoke, report UK researchers.

17 Oct 2012

DNA damage response contains previously unknown components: Study

Researchers at Moffitt Cancer Center and colleagues at the University of South Florida; Duke University; Johns Hopkins University; the Brazilian National Cancer Institute; and the Rio de Janeiro Federal Institute of Education, Science and Technology have discovered that an intricate system to repair DNA damage called the "DNA damage response" (DDR) contains previously unknown components, including proteins that could be targeted as sensitizers for chemotherapy.

17 Oct 2012

Chloride-restrictive intravenous strategy may decrease incidence of AKI among critically ill patients

In a pilot study assessing the effect of different levels of chloride in intravenous fluids administered to critically ill patients in an intensive care unit, restricting the amount of chloride administration was associated with a significant decrease in the incidence of acute kidney injury and the use of renal replacement therapy, according to a study in the October 17 issue of JAMA.

17 Oct 2012

Stat5 protein could serve as biomarker to help guide prostate cancer treatment

Men who had high levels of the activated Stat5 protein in their prostate cancer after a radical prostatectomy were more likely to have a recurrence or die from the disease compared to men who had little to no presence of the growth protein, according to a recent study published in Human Pathology by Jefferson's Kimmel Cancer Center researchers.

17 Oct 2012

FGF21 hormone markedly increases life span in mice

A study by UT Southwestern Medical Center researchers finds that a starvation hormone markedly extends life span in mice without the need for calorie restriction.

17 Oct 2012

Study determines how Trop2 protein drives growth of tumor cells in prostate and other epithelial cancers

Researchers led by Tanya Stoyanova and Dr. Owen Witte of UCLA's Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have determined how a protein known as Trop2 drives the growth of tumor cells in prostate and other epithelial cancers.

17 Oct 2012

Salk findings on cold virus proteins may spur new cancer treatments

Cold viruses generally get a bad rap----which they've certainly earned----but new findings by a team of scientists at the Salk Institute for Biological Studies suggest that these viruses might also be a valuable ally in the fight against cancer.

17 Oct 2012

EMR before radiofrequency ablation safe and effective for patients with nodular Barrett's esophagus

A new study shows that endoscopic mucosal resection (EMR) before radiofrequency ablation (RFA) is a safe and effective treatment option for patients with nodular Barrett's esophagus (BE) and advanced neoplasia.

17 Oct 2012

Robert Wood Johnson Foundation announces winners of 2012 Community Health Leaders Award

The Robert Wood Johnson Foundation is proud to announce today the recipients of its 2012 Community Health Leaders Award, honoring 10 individuals who have surmounted significant challenges to help improve health and health care in their communities.

17 Oct 2012

Recurrent patterns of genomic imbalances determine evolution of invasive breast cancer

Ductal carcinoma in situ (DCIS) is considered a precursor lesion for invasive breast cancer if untreated, and is found in approximately 45% of patients with invasive ductal carcinoma (IDC). Patients with DCIS only (not accompanied by invasive disease) have a 5-year-survival of nearly 100%, compared to 89% for all stages of invasive breast cancer (24% for patients with distant metastasis).

17 Oct 2012

BioLineRx completes pre-clinical development of BL-8020 for HCV

BioLineRx, a biopharmaceutical development company, announced today that it has successfully completed the pre-clinical development of BL-8020, an orally available, interferon-free treatment for the Hepatitis C virus (HCV), and plans to commence a Phase I/II safety and efficacy study for BL-8020 in Europe during the first quarter of 2013.

17 Oct 2012

Adults with HIV can benefit from cognitive training exercises

As more effective antiretroviral therapy has evolved over the past 30 years, HIV/AIDS has shifted from an acute to a chronic condition. But as patients live longer, research indicates that they are experiencing cognitive impairments at a higher rate than people without the disease.

17 Oct 2012

Philips to showcase advancements that allow patients to sleep and breathe easier at Medtrade 2012

Philips Respironics, a unit of Royal Philips Electronics, today at Medtrade 2012 showcases advancements that allow patients to sleep and breathe easier, demonstrating its commitment to improving the quality of life of those who suffer from chronic sleep and respiratory conditions.

17 Oct 2012