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Discovery may lead to new treatment approach for people with alcohol-associated liver disease

Investigators at Cedars-Sinai have uncovered a new pathway that helps explain how consuming too much alcohol causes damage to the liver, specifically mitochondrial dysfunction in alcohol-associated liver disease.

14 Feb 2022

Study reveals that 1PBC and niclosamide bind the same drug-binding pocket

Researchers used cryo-EM to demonstrate that 1PBC, and the drug niclosamide, both inhibitors of TMEM16 proteins, have therapeutic potential and may be used for COVID-19 treatment.

14 Feb 2022

Testes found to be a viral reservoir for SARS-CoV-2 replication

In a recent study posted to the medRxiv* pre-print server, researchers used a suite of methods to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the testis of patients who died from coronavirus disease 2019 (COVID-19) to gain insights into SARS-CoV-2 tropism inside testis and its impact on male fertility.

13 Feb 2022

Hollings researcher receives grant to fight complications after pediatric bone marrow transplant

MUSC Hollings Cancer Center researcher Sophie Paczesny, M.D., Ph.D., recently received a four-year grant from the National Heart, Lung, and Blood Institute to investigate solutions to help doctors to fight complications after pediatric bone marrow transplantation (BMT).

12 Feb 2022

New class of compounds can improve multiple aspects of metabolic syndrome, mice study shows

A study in mice - led by researchers at Washington University School of Medicine in St. Louis - shows that a new class of compounds the scientists developed can improve multiple aspects of metabolic syndrome.

12 Feb 2022

New system enables automatic analysis of biomedical videos captured by microscopy

Researchers at the Universidad Carlos III de Madrid have developed a system based on computer vision techniques that allows automatic analysis of biomedical videos captured by microscopy in order to characterize and describe the behavior of the cells that appear in the images.

12 Feb 2022

Molecular cage helps researchers to get atomic-level details of key cancer protein

Acute myeloid leukemia (AML), the American Cancer Institute estimates, will affect more than 20,000 Americans this year and kill more than 11,000 of them.

11 Feb 2022

First unbiased proteome scale study expands the number of known transcriptional activators

Also known as transcriptional activators for their ability to induce transcription of genes into RNA messages, these proteins are essential for the cells to function properly. Yet little is known about these proteins, and it wasn't clear how many activators there might be in human cells – until now.

11 Feb 2022

Scientists discover a new class of potential drug targets for neurodegenerative diseases

Oregon State University scientists have discovered a new class of potential drug targets for people suffering from neurodegenerative conditions such as Alzheimer's, Parkinson's and Lou Gehrig's disease.

10 Feb 2022

Novel molecule shows ability to inhibit the replication of all coronaviruses

Uppsala researchers have succeeded in designing a molecule that inhibits the replication of coronaviruses and that has great potential for development into a drug suitable for treating COVID-19.

10 Feb 2022

Researchers reveal new therapeutic way to block oncogenic RAS mutants

As a 10-year journey comes to fruition, MUSC Hollings Cancer Center researcher John O'Bryan, Ph.D., and colleagues have demonstrated a new therapeutic way to block a protein that is frequently mutated in cancers.

9 Feb 2022

Super-resolution imaging of the human coronavirus genome during infection

Using high-throughput confocal super-resolution microscopy, scientists visualize the genomic material of the human coronavirus HCoV-229E.

9 Feb 2022

Research may lead to the development of effective fasting-based therapies

Voluntary fasting, for example interval fasting, is beneficial to health for many people, depending on their individual condition. For example, controlled periods of starvation can prevent and improve diseases such as diabetes and obesity.

9 Feb 2022

Research reveals why Black women experience higher breast cancer mortality

New research from Sanford Burnham Prebys has revealed significant molecular differences between the breast cells of white and Black women that help explain why Black women experience higher breast cancer mortality.

9 Feb 2022

UCLA researchers develop a smartwatch that assesses cortisol levels found in sweat

The human body responds to stress, from the everyday to the extreme, by producing a hormone called cortisol.

9 Feb 2022

Old FDA-approved drug may protect against lung injury and blood clots in severe COVID-19

An FDA-approved drug that has been in clinical use for more than 70 years may protect against lung injury and the risk of blood clots in severe COVID-19 and other disorders that cause immune-mediated damage to the lungs, according to a preclinical study from researchers at Weill Cornell Medicine and Cold Spring Harbor Laboratory.

8 Feb 2022

FDA-approved drug prevents the immune system from producing neutrophil extracellular traps

A team of scientists led by Cold Spring Harbor Laboratory (CSHL) have discovered that disulfiram, an FDA-approved drug, prevents the immune system from producing toxic webs known as neutrophil extracellular traps (NETs).

8 Feb 2022

Mechanical hearts can generate new muscle tissue in the failing human heart

Mechanical hearts spur some regeneration in dormant parts of failing hearts, according to a UT Southwestern pilot study that shows promise for developing regenerative heart therapies.

8 Feb 2022

Investigating taraxerol as a protease inhibitor against SARS-CoV-2

In a recent study posted to the Research Square preprint* server, a team of researchers investigated the toxicity and absorption, distribution, metabolism, and excretion (ADME) characteristics of a potent herbal drug, taraxerol, in the management of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The paper is under consideration for publication in the Structural Chemistry journal.

7 Feb 2022

Discovery shows promise for development of a new non-hormonal contraceptive

A discovery that blocks the normal transition of semen from a thick gel to a liquid shows promise for development of a new form of non-hormonal, over-the-counter contraception.

7 Feb 2022

Molecule News and Research

Discovery may lead to new treatment approach for people with alcohol-associated liver disease

Study reveals that 1PBC and niclosamide bind the same drug-binding pocket

Testes found to be a viral reservoir for SARS-CoV-2 replication

Hollings researcher receives grant to fight complications after pediatric bone marrow transplant

New class of compounds can improve multiple aspects of metabolic syndrome, mice study shows

New system enables automatic analysis of biomedical videos captured by microscopy

Molecular cage helps researchers to get atomic-level details of key cancer protein

First unbiased proteome scale study expands the number of known transcriptional activators

Scientists discover a new class of potential drug targets for neurodegenerative diseases

Novel molecule shows ability to inhibit the replication of all coronaviruses

Researchers reveal new therapeutic way to block oncogenic RAS mutants

Super-resolution imaging of the human coronavirus genome during infection

Research may lead to the development of effective fasting-based therapies

Research reveals why Black women experience higher breast cancer mortality

UCLA researchers develop a smartwatch that assesses cortisol levels found in sweat

Old FDA-approved drug may protect against lung injury and blood clots in severe COVID-19

FDA-approved drug prevents the immune system from producing neutrophil extracellular traps

Mechanical hearts can generate new muscle tissue in the failing human heart

Investigating taraxerol as a protease inhibitor against SARS-CoV-2

Discovery shows promise for development of a new non-hormonal contraceptive

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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