Preclinical News and Research

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Buck researchers investigate ketone bodies as possible therapeutic against COVID-19

Given the disproportionate impact that COVID-19 has on older adults in terms of death and lasting disability, and the impact of common aging-related comorbidities like diabetes and cardiovascular disease, Buck Institute professor and practicing geriatrician John Newman, MD, PhD, can make a compelling argument that those infected with the SARS-CoV2 virus are suffering from an aging-related disease, no matter how old they are when they get infected.

15 Jul 2020

NanoSurface Biomedical is now Curi Bio

NanoSurface Biomedical, a leading developer of human stem cell-based biotechnology products, today announced a comprehensive rebrand, including a change of the company’s name to Curi Bio.

From Curi Bio 15 Jul 2020

Altimmune announces positive preclinical results of intranasal COVID-19 vaccine candidate

Altimmune, Inc., a clinical-stage biopharmaceutical company, has announced positive results from the preclinical studies conducted in mice at the University of Alabama at Birmingham of its intranasal COVID-19 vaccine candidate, AdCOVID.

13 Jul 2020

Molecular imaging reveals inter-organ communication between the heart and kidneys after heart attack

Whole body positron emission tomography (PET) has, for the first time, illustrated the existence of inter-organ communication between the heart and kidneys via the immune system following acute myocardial infarction, or heart attack.

13 Jul 2020

New theranostic agents show efficacy for precision diagnosis, treatment of prostate cancer

Researchers have developed a new pair of agents that show exceptional effectiveness for precision diagnosis and treatment of prostate cancer in preclinical studies.

13 Jul 2020

Delirium linked to long-term cognitive decline

A new meta-analysis of 24 observational studies from researchers at Columbia University Vagelos College of Physicians and Surgeons found that delirium may cause significant long-term cognitive decline.

13 Jul 2020

New opioid medication may slow the progression of osteoarthritis

A novel preclinical study by Keck Medicine of USC researchers, published in Arthritis & Rheumatology, reveals that a potential new opioid medication may have the ability to slow the progression of osteoarthritis while being less addictive than commonly prescribed opioid drugs.

13 Jul 2020

Newly discovered chemical compound shows potential to become treatment for brain disorders

Researchers at IIT-Istituto Italiano di Tecnologia (Italian Institute of Technology) discovered a novel chemical compound, which has the potential to became a new drug for the treatment of core symptoms of brain disorders like Down syndrome and autism.

11 Jul 2020

Researchers set up Gate2Brain to exploit a novel drug-transporting technology

Researchers from IRB Barcelona, the University of Barcelona (UB) and the Sant Joan de Déu Research Institute - Hospital Sant Joan de Déu (SJD) have set up Gate2Brain, a company based on a novel technology developed at IRB Barcelona to transport drugs into the brain.

10 Jul 2020

Volunteers can now register for coronavirus disease vaccine trials

In an attempt to recruit many volunteers, the National Institute of Allergy and Infectious Diseases (NIAID) has established a new clinical COVID-19 Prevention Trials Network (COVPN) that aims to enroll thousands of volunteers to test various investigational vaccines against the SARS-CoV-2 infection.

10 Jul 2020

Pigs and chickens not susceptible to SARS-CoV-2

A team of researchers in Germany aimed to investigate the susceptibility of potential animal hosts and the risk of zoonosis spill-over infections, which are illnesses transmitted to humans from animals. On the other hand, reverse zoonosis pertains to infections in humans that jump to animals.

9 Jul 2020

New cancer vaccine shows promising signs in preclinical studies

Scientists are ready to trial a new cancer vaccine in humans following the successful outcome of their preclinical studies.

9 Jul 2020

Remdesivir potently inhibits SARS-CoV-2 in human lung cell cultures

The news about remdesivir, the investigational anti-viral drug that has shown early promise in the fight against COVID-19, keeps getting better.

9 Jul 2020

New nanoconjugate blocks dissemination of tumor cells in animal models of acute myeloid leukemia

The nanoparticle targets only leukemic cells and therefore would reduce the severe adverse effects of current treatments.

9 Jul 2020

siRNA therapeutics can reduce off-target side effects of anticancer drugs

Small interfering RNA (siRNA) has shown tremendous potential for treating human diseases in the past decades.

9 Jul 2020

Lung physiology and immune function could spare children from severe COVID-19

Differences in lung physiology and immune function in children could be why they are more often spared from severe illness associated with COVID-19 than adults, according to pediatric and adult physicians at The University of Texas Health Science Center at Houston and Baylor College of Medicine, who teamed up to investigate the disparity.

8 Jul 2020

New study provides insight into the origin and evolution of glioblastoma

Brain cancers have long been thought of as being resistant to treatments because of the presence of multiple types of cancer cells within each tumor. A new study uncovers a cancer cell hierarchy that originates from a single cancer cell type, which can be targeted to slow cancer growth.

8 Jul 2020

Scientists discover promising therapy to combat the growing epidemic of liver disease

In an effort to combat a growing worldwide epidemic of Nonalcoholic Fatty Liver Disease (NAFLD), scientists have discovered a new target and a new therapy that has shown promising results in preclinical mouse models, according to researchers at the University of Colorado Anschutz Medical Campus.

8 Jul 2020

Characterizing Polymorphs and Amorphous Form

Dr. Matteo Daldosso and Dr. Sebastian Wegner discuss novel solutions for the characterization of polymorphs and amorphous form APIs.

From Bruker BioSpin Group 8 Jul 2020

New technology can rapidly disrupt existing biofilms that account for chronic diseases

Chronic and recurrent bacterial diseases are treatment-resistant due to the ability of the pathogens to establish biofilms, which act as fortresses built of extracellular DNA and proteins to protect populations of the bacteria.

8 Jul 2020

Preclinical News and Research

Buck researchers investigate ketone bodies as possible therapeutic against COVID-19

NanoSurface Biomedical is now Curi Bio

Altimmune announces positive preclinical results of intranasal COVID-19 vaccine candidate

Molecular imaging reveals inter-organ communication between the heart and kidneys after heart attack

New theranostic agents show efficacy for precision diagnosis, treatment of prostate cancer

Delirium linked to long-term cognitive decline

New opioid medication may slow the progression of osteoarthritis

Newly discovered chemical compound shows potential to become treatment for brain disorders

Researchers set up Gate2Brain to exploit a novel drug-transporting technology

Volunteers can now register for coronavirus disease vaccine trials

Pigs and chickens not susceptible to SARS-CoV-2

New cancer vaccine shows promising signs in preclinical studies

Remdesivir potently inhibits SARS-CoV-2 in human lung cell cultures

New nanoconjugate blocks dissemination of tumor cells in animal models of acute myeloid leukemia

siRNA therapeutics can reduce off-target side effects of anticancer drugs

Lung physiology and immune function could spare children from severe COVID-19

New study provides insight into the origin and evolution of glioblastoma

Scientists discover promising therapy to combat the growing epidemic of liver disease

Characterizing Polymorphs and Amorphous Form

New technology can rapidly disrupt existing biofilms that account for chronic diseases

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