Clinical Trial News and Research

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First successful Phase 2 trial uses cutting-edge RNA CAR-T therapy to treat autoimmunity

Cartesian Therapeutics, a clinical-stage biotechnology company pioneering cell therapies for autoimmune diseases, announced today the publication of a landmark paper in The Lancet Neurology.

22 Jun 2023

Do Panax notoginseng saponins (Xuesaitong soft capsules) improve function in patients with ischemic stroke?

Researchers examined the effectiveness and safety of using Panax notoginseng saponins for ischemic stroke in adults.

22 Jun 2023

Hypertension drug shown to prevent post-traumatic headaches

A study led by VA Puget Sound Health Care System researchers has shown that prazosin, a drug used to treat high blood pressure, can prevent posttraumatic headaches.

21 Jun 2023

Single mutation of the hepatitis E virus stands in the way of sofosbuvir drug's effectiveness

A single mutation stands in the way of a drug's effectiveness. Understanding it helps find new therapeutic approaches.

21 Jun 2023

Study investigates the sustainability in blood pressure reduction through a 12-month lifestyle intervention

The sustainability and scalability of limited duration interventions in low- and middle-income countries remain unclear.

21 Jun 2023

Novel approach to multimodal aging clock for interpretable age prediction and target discovery

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 11, entitled, "Precious1GPT: multimodal transformer-based transfer learning for aging clock development and feature importance analysis for aging and age-related disease target discovery."

21 Jun 2023

Study investigates whether metformin mitigates androgen deprivation therapy-related metabolic syndrome

A new research paper was published in Oncotarget's Volume 14 on June 19, 2023, entitled, "Utilizing metformin to prevent metabolic syndrome due to androgen deprivation therapy (ADT): a randomized phase II study of metformin in non-diabetic men initiating ADT for advanced prostate cancer."

21 Jun 2023

3D-printed vaginal ovules offer promising treatment for endometriosis

3D-printed vaginal ovules offer controlled release and targeted treatment, showing promise for conditions like endometriosis.

20 Jun 2023

Treatment with dupilumab leads to sustained improvements in COPD patients with type 2 inflammation

Chronic obstructive pulmonary disease patients with type 2 inflammation saw rapid and sustained improvements in their disease after treatment with the monoclonal antibody dupilumab, according to a yearlong, Phase 3 clinical trial reported in the New England Journal of Medicine.

20 Jun 2023

Cardiac MRI is a safe and valuable tool to help evaluate patients with acute chest pain

An estimated 3 million patients visit emergency departments each year with acute chest pain and mildly elevated troponin levels.

20 Jun 2023

Closed Loop Medicine appoints Kate Woolland as Chief Operating Officer

The key executive appointment supports the strategic, operational delivery of the Company’s product and partnership programs.

From Closed Loop Medicine 20 Jun 2023

Individuals with AUD show psychomotor impairment when challenged with a very high alcohol dose

While heavy drinkers can tolerate a certain amount of alcohol better than light or moderate drinkers, the concept of "holding your liquor" is more nuanced than commonly believed, according to new research from the University of Chicago.

18 Jun 2023

Testosterone therapy reduces gender dysphoria, depression and suicidality in trans adults

Receiving rapid access to testosterone therapy reduced feelings of gender dysphoria and led to a clinically significant reduction in depression as well as a 50% reduction in suicidality among transgender and gender diverse adults, according to research being presented Sunday at ENDO 2023, the Endocrine Society's annual meeting in Chicago, Ill.

18 Jun 2023

Intravenous treatment with MK-3402 can be an effective strategy in fighting antimicrobial resistance

New research by investigators in Ghent, Belgium shows that intravenous treatment with MK-3402, a metallo-beta-lactamase inhibitor, can be an effective strategy in fighting antimicrobial resistance. The findings are presented at ASM Microbe 2023, the annual meeting of the American Society for Microbiology.

18 Jun 2023

Broader search needed for successful management of eosinophilic gastritis

The good news: a monoclonal antibody treatment called benralizumab proved quite effective in a clinical trial at depleting the number of eosinophils found in the blood and digestive tract tissues of patients with eosinophilic gastritis.

16 Jun 2023

Wider use of high-dose hemodiafiltration may have benefits for kidney failure patients

Mortality in patients with kidney failure has been found to be 23% lower among those treated with high dose hemodiafiltration compared to those treated with high flux hemodialysis, according to new research from the CONVINCE consortium led by University Medical Center Utrecht.

16 Jun 2023

Catalent expands OneBio® suite for integrated development, manufacturing and supply across biologic modalities

Catalen today announced that it has expanded its integrated development, manufacturing and supply solution, OneBio® Suite, across a range of biologic modalities, including antibody and recombinant proteins, cell and gene therapies, and mRNA.

From Catalent 16 Jun 2023

Researchers review the principles of universal vaccine development for key pandemic potential viruses

A recent review addressed the efforts to develop universal vaccines for viruses at family and genus levels.

16 Jun 2023

Study concludes a single intramuscular injection of adintrevimab provides prophylactic efficacy against COVID-19 without safety concerns

Researchers evaluated the prophylactic immune protection conferred by a single intramuscular injection of adintrevimab (ADG20) against symptomatic COVID-19.

16 Jun 2023

$Fruquintinib improved survival in patients with refractory metastatic colorectal cancer$

Fruquintinib improved survival in patients with refractory metastatic colorectal cancer

Researchers from The University of Texas MD Anderson Cancer Center reported study results showing that the targeted therapy fruquintinib significantly improved overall survival (OS) and progression-free survival (PFS) in patients with refractory metastatic colorectal cancer.

16 Jun 2023

Clinical Trial News and Research

First successful Phase 2 trial uses cutting-edge RNA CAR-T therapy to treat autoimmunity

Do Panax notoginseng saponins (Xuesaitong soft capsules) improve function in patients with ischemic stroke?

Hypertension drug shown to prevent post-traumatic headaches

Single mutation of the hepatitis E virus stands in the way of sofosbuvir drug's effectiveness

Study investigates the sustainability in blood pressure reduction through a 12-month lifestyle intervention

Novel approach to multimodal aging clock for interpretable age prediction and target discovery

Study investigates whether metformin mitigates androgen deprivation therapy-related metabolic syndrome

3D-printed vaginal ovules offer promising treatment for endometriosis

Treatment with dupilumab leads to sustained improvements in COPD patients with type 2 inflammation

Cardiac MRI is a safe and valuable tool to help evaluate patients with acute chest pain

Closed Loop Medicine appoints Kate Woolland as Chief Operating Officer

Individuals with AUD show psychomotor impairment when challenged with a very high alcohol dose

Testosterone therapy reduces gender dysphoria, depression and suicidality in trans adults

Intravenous treatment with MK-3402 can be an effective strategy in fighting antimicrobial resistance

Broader search needed for successful management of eosinophilic gastritis

Wider use of high-dose hemodiafiltration may have benefits for kidney failure patients

Catalent expands OneBio® suite for integrated development, manufacturing and supply across biologic modalities

Researchers review the principles of universal vaccine development for key pandemic potential viruses

Study concludes a single intramuscular injection of adintrevimab provides prophylactic efficacy against COVID-19 without safety concerns

Fruquintinib improved survival in patients with refractory metastatic colorectal cancer

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