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Potential tumor vulnerability may be exploited to improve treatment of neuroblastoma

A Ludwig Cancer Research study has identified a potential vulnerability in neuroblastoma tumors that might be exploited to improve treatment of the aggressive childhood cancer, which accounts for roughly 15% of all deaths from pediatric malignancies.

7 Feb 2022

Cocktail of two chemicals could help slow down age-related muscular decline

Researchers from Tokyo Metropolitan University have shown that a mixture of 5-aminolevulinic acid(5-ALA) hydrochloride and sodium ferrous citrate (SFC) helps slow down aging-related muscular decline in fruit flies, leading to a slower decline in locomotor activity and longer lifespans.

7 Feb 2022

Scientists reveal how droplets of transcription factors collectively read DNA regions to switch on genes

Life starts with one cell. When an organism develops, dividing cells specialize to form the variety of tissues and organs that build up the adult body, while keeping the same genetic material – contained in our DNA.

6 Feb 2022

Scientists elucidate the structure of central cellular inflammatory switch

Researchers at the Universities of Bonn and Regensburg have elucidated the structure of a central cellular inflammatory switch.

4 Feb 2022

Roswell Park scientists identify a potential new treatment target for pancreatic cancer

Scientists at Roswell Park Comprehensive Cancer Center have identified a potential new target for the treatment of pancreatic cancer.

3 Feb 2022

Scientists identify genome regions linked to migraine risk

An international consortium of leading migraine scientists identified more than 120 regions of the genome that are connected to risk of migraine.

3 Feb 2022

Study offers unprecedented insight into the mechanism of action of topo VI enzyme

The function of an enzyme, critical to most forms of life, has been revealed.

2 Feb 2022

CECR2 gene inhibition prevents triple-negative breast cancer from metastasizing, study shows

A new study by researchers at Yale Cancer Center shows inhibition of the CECR2 gene prevents triple-negative breast cancer from advancing or metastasizing.

2 Feb 2022

Researchers visualize protein machinery of respiration for the first time

Oxygen and sugar are the basis of life for animals, plants, fungi and many bacteria. The metabolic process called respiration makes it possible to convert food into energy for the cells.

31 Jan 2022

Researchers use microscopic strands of DNA to assemble hydrogel blocks

Researchers from the Okinawa Institute of Science and Technology Graduate University (OIST) have used microscopic strands of DNA to guide the assembly of gel blocks that are visible to the naked eye.

31 Jan 2022

3C-like protease inhibitor clinical candidate, S-217622, as a treatment for SARS-CoV-2

In a new study, a team of researchers discovered S-217622, a non-covalent SARS-CoV-2 3C-like protease (3CLpro) inhibitor clinical candidate for the treatment of COVID-19.

31 Jan 2022

Binding and conformational properties of the SARS-CoV spike protein and hACE2 complex

A new paper in the journal Molecules describes this in molecular terms, comparing SARS-CoV-2 with an earlier highly pathogenic coronavirus, SARS-CoV.

31 Jan 2022

Damon Runyon Cancer Research Foundation announces newest cohort of Fellows and Breakthrough Scientists

The Damon Runyon Cancer Research Foundation has announced its newest cohort of Damon Runyon Fellows, 13 outstanding postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators.

29 Jan 2022

Study provides atomistic level insight into target residence time of small molecule kinase inhibitors

When a drug molecule binds to its target protein, it stays bound for some time before eventually unbinding the target. The actual time how long a drug molecule resides bound to its target varies among compounds.

29 Jan 2022

Novel molecular signaling pathway plays a key role in producing osteoarthritis pain

Researchers from North Carolina State University have discovered that a particular molecular signaling pathway plays an important role in producing osteoarthritis (OA) pain.

27 Jan 2022

Targeting CHI3L1 inhibits SARS-CoV-2 variants, including Delta and Omicron

Researchers show that the CHI3L1 inhibitors reduce epithelial cell infection by SARS-CoV-2 VOC pseudovirus moieties.

27 Jan 2022

New imaging method reveals the inner workings of a family of light-sensing molecules

Using an innovative new imaging technique, researchers at Weill Cornell Medicine have revealed the inner workings of a family of light-sensing molecules in unprecedented detail and speed. The work could inform new strategies in the burgeoning field of optogenetics, which uses light pulses to alter the activity of individual neurons and other cells.

27 Jan 2022

‘Lefty’ protein pumps the brakes during initial stages of embryo differentiation

A protein known as Lefty pumps the brakes as human embryos begin to differentiate into the bones, soft tissues and organs that make us.

25 Jan 2022

Scientists explore how proteins bind with specific companions inside cells

Despite its minute size, a single cell contains billions of molecules that bustle around and bind to one another, carrying out vital functions. The human genome encodes about 20,000 proteins, most of which interact with partner proteins to mediate upwards of 400,000 distinct interactions.

25 Jan 2022

Beta-amyloid deposits found in young patients with COVID-19

A new study describes the finding that patients of COVID-19 exhibit large amounts of focal β-amyloid deposits in their neocortical tissues.

25 Jan 2022

Molecule News and Research

Potential tumor vulnerability may be exploited to improve treatment of neuroblastoma

Cocktail of two chemicals could help slow down age-related muscular decline

Scientists reveal how droplets of transcription factors collectively read DNA regions to switch on genes

Scientists elucidate the structure of central cellular inflammatory switch

Roswell Park scientists identify a potential new treatment target for pancreatic cancer

Scientists identify genome regions linked to migraine risk

Study offers unprecedented insight into the mechanism of action of topo VI enzyme

CECR2 gene inhibition prevents triple-negative breast cancer from metastasizing, study shows

Researchers visualize protein machinery of respiration for the first time

Researchers use microscopic strands of DNA to assemble hydrogel blocks

3C-like protease inhibitor clinical candidate, S-217622, as a treatment for SARS-CoV-2

Binding and conformational properties of the SARS-CoV spike protein and hACE2 complex

Damon Runyon Cancer Research Foundation announces newest cohort of Fellows and Breakthrough Scientists

Study provides atomistic level insight into target residence time of small molecule kinase inhibitors

Novel molecular signaling pathway plays a key role in producing osteoarthritis pain

Targeting CHI3L1 inhibits SARS-CoV-2 variants, including Delta and Omicron

New imaging method reveals the inner workings of a family of light-sensing molecules

‘Lefty’ protein pumps the brakes during initial stages of embryo differentiation

Scientists explore how proteins bind with specific companions inside cells

Beta-amyloid deposits found in young patients with COVID-19

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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