Preclinical News and Research

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Asthma inhalers being trialed for treatment of COVID-19

Researchers from Queensland University of Technology and Oxford University are working in collaboration to begin human clinical trials of inhaled corticosteroids, commonly used for asthma patients, on patients with COVID-19. The researchers believe that this could be useful for patients with the novel coronavirus infection.

7 Jul 2020

Many in the UK would refuse a coronavirus vaccine, survey finds

The novel coronavirus pandemic (COVID-19) has left many scientists and pharmaceutical companies racing to develop an effective vaccine to combat the viral infection. With 21 candidate vaccines in clinical evaluation, 139 candidate vaccines in preclinical evaluation across the world, most countries are hoping to be first to the post.

7 Jul 2020

Dutch trial of convalescent plasma in COVID-19 discontinued

Now, a recent trial published on the preprint server medRxiv* in July 2020 reports that a majority of hospitalized COVID-19 patients have a high titer of neutralizing antibodies, at the time of admission, within 10 days of symptomatic disease.

7 Jul 2020

New vitamin K-based drug eliminates medication-resistant epileptic seizures in mice

In the cover article of the June 11 issue of the Journal of Medicinal Chemistry, a team of researchers at the Medical University of South Carolina, led by Sherine Chan, Ph.D., and James Chou, Ph.D., reports that a new vitamin K-based drug has proved effective in mouse models of medication-resistant seizures.

6 Jul 2020

Human trials of potential COVID-19 vaccine commence in South Australia

A potential COVID-19 vaccine developed at Flinders University has commenced human trials in South Australia.

6 Jul 2020

New editorial published following adverse events of gene therapy clinical trial

The Editor-in-Chief of Human Gene Therapy, the first journal devoted to the field of gene therapy, and one of the world's leading experts on gene therapy have co-authored a new editorial, Moving Forward After Two Deaths in a Gene Therapy Trial of Myotubular Myopathy, in response to the news of two deaths in a now-halted gene therapy clinical trial.

3 Jul 2020

New platform prioritizes synergistic drug combinations against SARS-CoV-2

Researchers in the U.S. have used a new web-based platform to help identify synergistic and antagonistic drug combinations and their underlying mechanisms of action in the context of coronavirus disease 2019 (COVID-19).

2 Jul 2020

Extended culture of human pancreatic slices as a model to study regeneration of beta cells

Scientists from the Diabetes Research Institute (DRI) at the University of Miami Miller School of Medicine have developed a method allowing for the long-term culture of "pancreatic slices" to study the regeneration of the human pancreas in real time.

1 Jul 2020

Researchers receive innovative grants to understand the biological underpinnings of blood cancers

Seeking to ignite the next major breakthroughs to treat blood cancers, The Leukemia & Lymphoma Society (LLS), The Mark Foundation, and The Paul G. Allen Frontiers Group today announced more than $6.75 million awarded to nine of the most exceptional scientists in the field.

1 Jul 2020

New polymeric heart valve could be a life-saver

Millions of persons around the world suffer from diseased and damaged heart valves. These patients require valve repair surgeries, and often when that is not possible, they need to take blood-thinners for life to prevent complications.

30 Jun 2020

Researchers develop artificial liquid retinal prosthesis to counteract the effects of eye disorders

Researchers at IIT-Istituto Italiano di Tecnologia (Italian Institute of Technology) has led to the revolutionary development of an artificial liquid retinal prosthesis to counteract the effects of diseases such as retinitis pigmentosa and age-related macular degeneration that cause the progressive degeneration of photoreceptors of the retina, resulting in blindness.

30 Jun 2020

Modified Vaccinia Ankara-based vaccine candidate for SARS-CoV-2

Now, a new study by researchers at Emory University, the University of Texas Medical Branch and the Ragon Institute and published on the preprint server bioRxiv in June 2020 reports the development of a promising new vaccine candidate that may rapidly and effectively induce the production of neutralizing antibodies against the spike protein of the virus.

30 Jun 2020

Bioengineered uterine tissue can support normal pregnancies, study shows

In new research from the Wake Forest Institute for Regenerative Medicine (WFIRM), scientists have shown that bioengineered uteri supported fertilization, fetal development, and live birth with normal offspring.

29 Jun 2020

New eye drops could prevent vision loss after retinal vein occlusion

Researchers at Columbia University Irving Medical Center have developed eye drops that could prevent vision loss after retinal vein occlusion, a major cause of blindness for millions of adults worldwide.

29 Jun 2020

New polymeric heart valve is a promising alternative for valve replacement surgery, study shows

A new polymeric heart valve with a life span potentially longer than current artificial valves that would also prevent the need for the millions of patients with diseased heart valves to require life-long blood thinning tablets has been developed by scientists at the universities of Bristol and Cambridge.

29 Jun 2020

Interactive cloud-based data portal provides access to treasure trove of pediatric solid tumor data

An innovative, interactive cloud-based data portal debuted this week that lets academic researchers mine the world's largest and most comprehensive collection of scientific resources for studying pediatric solid tumors and their related biology.

26 Jun 2020

International study uncovers three molecules with potential for treating epilepsy

A major international study has uncovered three molecules that have the potential to be developed into new drugs to treat epilepsy.

26 Jun 2020

Entos Pharmaceuticals selects two lead DNA vaccine candidates for COVID-19

Entos Pharmaceuticals, a healthcare biotechnology company developing nucleic acid medicines with its Fusogenix drug delivery platform, today announced the selection of two lead candidates for a pan-coronavirus Fusogenix DNA vaccine from its prototyping program launched at the onset of the global COVID-19 pandemic.

25 Jun 2020

New study assesses cardiac problems in elite female athletes

The first-ever cardiac study of elite female basketball players in the United States shows how their hearts adapt to intense physical training.

25 Jun 2020

Far-UVC light can efficiently and safely kill airborne coronaviruses

More than 99.9% of seasonal coronaviruses present in airborne droplets were killed when exposed to a particular wavelength of ultraviolet light that is safe to use around humans, a new study at Columbia University Irving Medical Center has found.

24 Jun 2020

Preclinical News and Research

Asthma inhalers being trialed for treatment of COVID-19

Many in the UK would refuse a coronavirus vaccine, survey finds

Dutch trial of convalescent plasma in COVID-19 discontinued

New vitamin K-based drug eliminates medication-resistant epileptic seizures in mice

Human trials of potential COVID-19 vaccine commence in South Australia

New editorial published following adverse events of gene therapy clinical trial

New platform prioritizes synergistic drug combinations against SARS-CoV-2

Extended culture of human pancreatic slices as a model to study regeneration of beta cells

Researchers receive innovative grants to understand the biological underpinnings of blood cancers

New polymeric heart valve could be a life-saver

Researchers develop artificial liquid retinal prosthesis to counteract the effects of eye disorders

Modified Vaccinia Ankara-based vaccine candidate for SARS-CoV-2

Bioengineered uterine tissue can support normal pregnancies, study shows

New eye drops could prevent vision loss after retinal vein occlusion

New polymeric heart valve is a promising alternative for valve replacement surgery, study shows

Interactive cloud-based data portal provides access to treasure trove of pediatric solid tumor data

International study uncovers three molecules with potential for treating epilepsy

Entos Pharmaceuticals selects two lead DNA vaccine candidates for COVID-19

New study assesses cardiac problems in elite female athletes

Far-UVC light can efficiently and safely kill airborne coronaviruses

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