Cell Metabolism News and Research

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Study: Effect of diabetes medication can be blocked by a molecule from gut bacteria

The action of metformin, the classic drug used to treat diabetes by stabilizing blood sugar, can be blocked by a molecule from the bacteria in our intestines, a University of Gothenburg study shows.

11 Nov 2020

ERC Synergy project explores causes of drug tolerance in intractable fungal infections

Over the next six years, research groups at Charité - Universitätsmedizin Berlin and Tel Aviv University will study how invasive fungal pathogens are able to evade treatments and develop tolerance to antifungal drugs.

10 Nov 2020

Study: Blocking energy pathway helps reduce graft-versus-host disease

MUSC Hollings Cancer Center researchers identified that blocking an alternative energy pathway for T-cells after hematopoietic stem cell transplant helps reduce graft-versus-host disease (GVHD) in an animal model of leukemia.

5 Nov 2020

High Throughput Identification and Quantification of Breast Cancer With NMR-Based Metabolomics

Breast cancer is the leading cause of cancer-related death among the female population globally, despite the ever-growing technology of early detection.

From Bruker BioSpin Group 30 Oct 2020

Researchers aim to identify disease tolerance mechanisms in sepsis patients

Sepsis is estimated to cause 11 million deaths every year in the world. Its treatment is based on the use of antibiotics and organ support measures, but many times it fails due to unsuccessful attempts at modulating the immune response.

16 Oct 2020

Study reveals link between composition of intestinal microbiota and cognitive performance

Since 2006, several studies have shown that morbid obesity is associated with impaired immediate and recent memory.

14 Oct 2020

Researchers identify a mechanism to prevent hair loss

An international research group headed by Associate Professor Sara Wickström at the University of Helsinki has identified a mechanism that is likely to prevent hair loss.

13 Oct 2020

Researchers create p16-Cre ERT2 -tdTomato mouse model to characterize in vivo senescent cells

Cell senescence is a state of permanent cell cycle arrest that was initially defined for cells grown in cell culture. It plays a key role in age-associated organ dysfunction and age-related diseases such as cancer, but the in vivo pathogenesis is largely unclear.

7 Oct 2020

Researchers have discovered a safe, non-invasive way to manage blood sugar

Researchers from the University of Iowa may have discovered a safe new way to manage blood sugar non-invasively. Exposing diabetic mice to a combination of static electric and magnetic fields for a few hours per day normalizes two major hallmarks of type 2 diabetes, according to new findings published Oct. 6 in Cell Metabolism.

7 Oct 2020

Blocking the self-destruction process of enzymes can mitigate age-related diseases

Stopping the cannibalistic behavior of a well-studied enzyme could be the key to new drugs to fight age-related diseases, according to a new study published online in Nature Cell Biology.

30 Sep 2020

New mechanism that prevents hair loss identified

A team of researchers from Cologne and Helsinki has discovered a mechanism that prevents hair loss: hair follicle stem cells, essential for hair to regrow, can prolong their life by switching their metabolic state in response to low oxygen concentration in the tissue.

28 Sep 2020

Heat and gut microbiota promote stronger bones

Osteoporosis, a bone disease linked to ageing, is characterized by a loss of bone density, micro-architectural deterioration of the bones and an increased risk of fractures.

11 Sep 2020

Polygenic risk score can predict risk of drug-induced liver injury

Scientists who were working on a way to determine the viability of batches of tiny liver organoids have discovered a testing method that may have far broader implications.

7 Sep 2020

Researchers develop novel model to study factors that cause type 2 diabetes

Using cells taken from patients with type 2 diabetes and new techniques to convert them into specialized precursors of muscle cells, researchers have developed a novel 'disease-in-a-dish' model to study the basic molecular factors that lead to the development of type 2 diabetes.

4 Sep 2020

Study reveals a troubling connection between coronavirus and obesity

A review of COVID-19 studies reveals a troubling connection between two health crises: coronavirus and obesity.

26 Aug 2020

Developing more precise, targeted therapy for a highly aggressive breast cancer

Taking advantage of a cancer cell's altered metabolism that drives its runaway growth, Princess Margaret researchers are zeroing in on these molecular changes to help them develop more precise drug targets for one of the most deadly breast cancers.

21 Aug 2020

Manipulating cancer cell metabolism may help combat DIPGs and other brain tumors

Every year, 150 to 300 children in the United States are diagnosed with diffuse intrinsic pontine gliomas (DIPGs), aggressive and lethal tumors that grow deep inside the brain, for which there are no cures.

18 Aug 2020

COVID-19 virus acts as a 'sponge' to deplete specific host microRNAs

Why is the COVID-19 virus deadly, while many other coronaviruses are fairly innocuous and just cause colds?

15 Aug 2020

Membrane nanoparticles acts as a bait to trap SARS-CoV-2

In an exciting new bioRxiv preprint research paper, Chinese researchers describe the development of membrane nanoparticles from ACE2-rich cells with a potent capacity to block the adherence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

13 Aug 2020

Researchers discover how to activate brown fat in humans

The receptor responsible for activating the energy-burning property of brown fat in humans has been identified.

5 Aug 2020