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Researchers identify immune expression signature in surgical specimens linked to disease progression for non-CPR patients

Researchers from Spain have identified an immune expression signature in surgical specimens associated with disease progression for non-complete pathological responders patients treated with neo adjuvant chemo-immunotherapy, which could help the follow-up and therapeutic management of these high-risk patients.

8 Aug 2022

The safety and preliminary efficacy of OP-101 in patients with severe COVID-19

Researchers assessed the impact of dendrimer nanotherapy in treating severe COVID-19.

8 Aug 2022

Researchers create a physical wiring diagram of the human immune system

In a new study, researchers systematically mapped the surface proteins on human leukocytes to examine interactions between their cell-surface proteomes and develop a physical wiring diagram encapsulating the diversity of surface protein architectures found across all major subsets of leukocytes.

8 Aug 2022

Gut microbiota-derived metabolites offer protection against SARS-CoV-2

A new study investigated how the gut microbiome confers immunity to mammalian hosts against SARS-CoV-2 intranasal infection by generating short-chain fatty acids.

5 Aug 2022

How does COVID-19 affect sexual and bladder functions in men?

Researchers discuss the impact of COVID-19 on the urogenital health of males.

1 Aug 2022

Decoy ACE2 receptors broadly neutralize SARS-CoV-2 variants

Researchers review current developments in preclinical studies associated with recombinant ACE2 decoy receptors against coronaviruses.

31 Jul 2022

Efficacy of COVID mRNA vaccines among patients on CAR‐T‐lymphocyte therapy

Researchers evaluate the effectiveness of mRNA COVID-19 vaccines among patients receiving CAR‐T‐lymphocyte therapy.

27 Jul 2022

Temporal changes in CD4 T-lymphocyte dynamics upon immunization against SARS-CoV-2 spike protein

Researchers assessed changes in CD4 T-lymphocyte temporal dynamics by evaluating T-lymphocyte responses to SARS-CoV-2 S using Foxp3-Tocky mice and Nr4a3-Tocky mice.

27 Jul 2022

Nasal spray highly effective against HIV and SARS-CoV-2 in animal models

The intranasal delivery of amph-protein vaccines is a potential approach to elicit a mucosal immune response against many infectious diseases.

26 Jul 2022

Improving the immune defenses against blood cancer

For patients with lymphoma, multiple myeloma, or certain types of leukemia, treatment with chimeric antigen receptor T cells (CAR T cells) is sometimes the last chance of overcoming the cancer.

22 Jul 2022

A different approach to build a more durable, broadly effective COVID-19 vaccine

Researchers at University of California San Diego School of Medicine, with colleagues elsewhere, describe a different way to build a COVID-19 vaccine, one that would, in theory, remain effective against new and emerging variants and could be taken as a pill, by inhalation or other delivery methods.

21 Jul 2022

FDA clears IND application for MD Anderson-sponsored Phase I clinical study of OBX-115 therapy

The University of Texas MD Anderson Cancer Center and Obsidian Therapeutics, Inc. today announced Food and Drug Administration (FDA) clearance of an Investigational New Drug (IND) application for an MD Anderson-sponsored Phase I clinical study of OBX-115, Obsidian's lead engineered tumor infiltrating lymphocyte (TIL) therapy candidate.

21 Jul 2022

Charged nanoparticles combined with a vaccine effective in eliminating melanoma tumors in mice

Cancers in humans have all sorts of ways to survive and thrive: Cells and tumors alike engage in devious means to deflect, deceive, and evade detection by our bodies’ immune systems.

20 Jul 2022

Cytokine-based cancer immunotherapy: current progress and future prospects

In this interview, News-Medical talks to Dr. Shuang Zhou about cytokine-base cancer immunotherapy, the current state of the field, and future prospects.

From Sino Biological Inc. 18 Jul 2022

Study shows that older adults can generate robust, long-lived memory against SARS-CoV-2 following infection

Researchers reported on the benefit of immunity developed by previous SARS-CoV-2 infection for overcoming the age-associated decline in COVID-19 vaccine effectiveness.

18 Jul 2022

Clinical presentation of monkeypox infection in two Israeli males

Researchers described the symptomatology and clinical manifestations of monkeypox infections among two Israeli patients.

12 Jul 2022

Study reveals sex-based differences in the clinical outcomes of COVID-19 in the US

Researchers investigated sex-based differences among COVID-19 patients in the United States.

11 Jul 2022

After 3 doses of COVID vaccine, most cancer patients retain detectable humoral immunity

In a recent study posted to the medRxiv* preprint server, researchers assessed the efficacy and durability of immune responses to the third dose of coronavirus disease 2019 (COVID-19) vaccines. They also assessed the efficacy of the fourth vaccine dose among severely immunocompromised patients with hematological malignancies.

7 Jul 2022

Intrahost genetic diversity and evolution of the SARS-CoV-2 B.1.517 lineage during chronic infection of an immunocompromised individual

Researchers investigated the intrahost evolution and genetic diversity of the SARS-CoV-2 B.1.517 variant in an immunosuppressed person with chronic COVID-19.

6 Jul 2022

What role does human microbiota play in COVID-19 severity?

In a recent study published in the journal Advanced Science, researchers explored the dynamic changes in the respiratory tract and gut microbiota in coronavirus disease 2019 (COVID-19) patients. They observed and analyzed these changes during different disease progression stages among patients with differential disease severities.

5 Jul 2022

Lymphocyte News and Research

Researchers identify immune expression signature in surgical specimens linked to disease progression for non-CPR patients

The safety and preliminary efficacy of OP-101 in patients with severe COVID-19

Researchers create a physical wiring diagram of the human immune system

Gut microbiota-derived metabolites offer protection against SARS-CoV-2

How does COVID-19 affect sexual and bladder functions in men?

Decoy ACE2 receptors broadly neutralize SARS-CoV-2 variants

Efficacy of COVID mRNA vaccines among patients on CAR‐T‐lymphocyte therapy

Temporal changes in CD4 T-lymphocyte dynamics upon immunization against SARS-CoV-2 spike protein

Nasal spray highly effective against HIV and SARS-CoV-2 in animal models

Improving the immune defenses against blood cancer

A different approach to build a more durable, broadly effective COVID-19 vaccine

FDA clears IND application for MD Anderson-sponsored Phase I clinical study of OBX-115 therapy

Charged nanoparticles combined with a vaccine effective in eliminating melanoma tumors in mice

Cytokine-based cancer immunotherapy: current progress and future prospects

Study shows that older adults can generate robust, long-lived memory against SARS-CoV-2 following infection

Clinical presentation of monkeypox infection in two Israeli males

Study reveals sex-based differences in the clinical outcomes of COVID-19 in the US

After 3 doses of COVID vaccine, most cancer patients retain detectable humoral immunity

Intrahost genetic diversity and evolution of the SARS-CoV-2 B.1.517 lineage during chronic infection of an immunocompromised individual

What role does human microbiota play in COVID-19 severity?

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