Neurodegenerative Diseases News and Research

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Polyglycine aggregates disrupt tRNA splicing and drive neurodegeneration

Neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, are devastating and incurable diseases.

17 Jul 2025

Standardized brain cell atlas to accelerate Parkinson's and Alzheimer's research

Researchers now have a powerful new way to understand the types of brain cells that are affected in neurodegenerative diseases and to uncover connections between conditions such as Parkinson's, Alzheimer's, and other forms of dementia.

17 Jul 2025

Research suggests a new strategy to improve blood flow to the brain to battle Alzheimer's

New University of Virginia School of Medicine research suggests an unexpected way doctors may be able to improve blood flow to the brain to battle Alzheimer's and other neurodegenerative diseases.

16 Jul 2025

New research offers hope to preserve vision in autosomal dominant optic atrophy

Autosomal dominant optic atrophy (ADOA), the most common genetic optic neuropathy, is an insidious disease. It often presents slowly during childhood by way of blurry vision, trouble reading or focusing, and sometimes only as a failed vision test.

16 Jul 2025

Harvard researchers uncover how the brain directs blood flow in real time

All day long, our brains carry out complicated and energy-intensive tasks such as remembering, solving problems, and making decisions.

16 Jul 2025

UK Biobank completes world's largest whole-body imaging project

In a remarkable achievement that is already impacting how we detect and diagnose disease, UK Biobank has completed the world's largest whole body imaging project, scanning the brains, hearts, abdomens, blood vessels, bones and joints of 100,000 volunteers.

16 Jul 2025

UNM researchers get $1 million grant to launch early clinical trial for Alzheimer’s vaccine

University of New Mexico researchers have received funding to launch an early-stage clinical trial of a vaccine engineered to clear pathological tau protein from the brains of patients suffering from Alzheimer's dementia.

15 Jul 2025

Scientists uncover key role of cypin in strengthening brain cell connections

Scientists have discovered how a key protein helps maintain strong connections between brain cells that are crucial for learning and memory.

11 Jul 2025

Explainable AI helps decode the substrate specificity of γ-secretase enzyme

Using artificial intelligence, researchers show how γ-secretase recognizes substrates - an important advance for fundamental and translational research.

11 Jul 2025

New device offers breakthrough for safe drug delivery into the brain

A new device combining ultrasound and advanced imaging to provide crucial information for the safe delivery of drugs into the brain has been developed by University of Queensland researchers.

11 Jul 2025

Fasting triggers neuroprotective changes that could delay dementia

Intermittent fasting could be a neuroprotective strategy, improving gut-brain axis function and reducing inflammation linked to neurodegenerative diseases.

11 Jul 2025

Mitochondria and peroxisomes work together to defend against cell damage

An international team led by researchers at The Hospital for Sick Children (SickKids), Princess Margaret Cancer Centre, Dalhousie University, the University of Exeter (UK) and the Medical University of Vienna (Austria) has uncovered a surprising way compartments within cells work together to defend themselves against oxidative stress, a finding that could shift how we understand age-associated conditions such as diabetes and neurodegenerative diseases.

10 Jul 2025

Can dietary copper help protect against dementia and memory loss?

Higher dietary copper intake was linked to better cognitive performance in older US adults, with benefits plateauing above a certain threshold. The effect was especially notable in stroke survivors, but further research is needed to confirm causality.

8 Jul 2025

Football headers trigger motor control changes in women

A study on women's football heading reveals subtle changes in fine motor function, raising concerns about long-term neurological effects and concussion risks.

4 Jul 2025

Targeting a key enzyme could reverse early Parkinson's effects

Putting the brakes on an enzyme might rescue neurons that are dying due to a type of Parkinson's disease that's caused by a single genetic mutation, according to a new Stanford Medicine-led study conducted in mice.

2 Jul 2025

Uncovering the link between viruses and neurodegeneration through primate models

In a comprehensive Genomic Press Innovators & Ideas interview, Dr. Danielle Beckman reveals how her passion for microscopy has evolved into a mission to understand viral impacts on brain health, offering hope for patients suffering from post-viral neurological symptoms.

2 Jul 2025

Glycogen metabolism in neurons emerges as key to fighting Alzheimer's

A new study from scientists at the Buck Institute for Research on Aging has revealed a surprising player in the battle against Alzheimer's disease and other forms of dementia: brain sugar metabolism.

1 Jul 2025

Proteome imbalance from aneuploidy linked to mitochondrial dysfunction

It has been known for several years that abnormal chromosome numbers lead to protein imbalances in the affected cells. Researchers at RPTU have now investigated the detailed effects of such imbalances.

27 Jun 2025

Harnessing saliva for precision medicine and early disease diagnosis

A research team led by the University of the Basque Country (Euskal Herriko Unibertsitatea, EHU) has identified hundreds of molecular markers in saliva that could reveal the risk of a person developing major diseases such as cancer, cardiovascular diseases, diabetes and neurodegenerative diseases.

26 Jun 2025

Researchers link brain waste clearance to early Alzheimer’s damage

A crucial link between the brain's cleaning system and deterioration of neurons associated with Alzheimer's disease has been discovered by University of Queensland researchers.

25 Jun 2025