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New study raises red flags about strategy to block cancer drug resistance

Sooner or later, most cancer patients develop resistance to the very chemotherapy drugs designed to kill their cancer, forcing oncologists to seek alternatives.

17 Apr 2020

Study looks into how malaria parasite evades the immune system

The parasite causing the most severe form of human malaria uses proteins to make red blood cells sticky, making it harder for the immune system to destroy it and leading to potentially fatal blood clots. New research at the Crick has identified how the parasite may control this process.

13 Apr 2020

Where cancers spread can give specific insights on disease traits

Kidney cancers that metastasize to the pancreas have a fundamentally different biology from those that metastasize elsewhere, with characteristics that can influence successful treatment, a study led by investigators with the UT Southwestern Kidney Cancer Program suggests.

12 Apr 2020

Cancer-causing mutation also promotes inflammation

Analyses of cell signals provide insight into the origin of severe inflammatory symptoms that appear in various types of blood cancer and point to possible therapeutic approaches: In around one-fourth of patients suffering from juvenile myelomonocytic leukemia, there is evidence of mutations in the so-called KRAS gene in the leukemia cells.

8 Apr 2020

Research suggests potential treatment target to slow lymphoma tumor growth

Researchers at the MDC observe the very early stages of blood vessel development in lymph node tumors.

7 Apr 2020

Study suggests targeted cancer therapy could help with rare neurologic disease

A targeted therapy currently studied for treatment of certain cancers may be beneficial in treating other neurologic diseases.

6 Apr 2020

Scientists uncover key molecular mechanism underlying different aspects of sepsis

Sepsis is a life-threatening condition that kills millions annually; it is poorly understood and has no specific treatment.

27 Mar 2020

Excessive salt intake weakens the immune system

A high-salt diet is not only bad for one's blood pressure, but also for the immune system. This is the conclusion of a current study under the leadership of the University Hospital Bonn.

25 Mar 2020

A high salt intake impairs immune response, study suggests

A study has shown that a high salt intake inhibits the immune system’s ability to combat bacteria.

25 Mar 2020

Study explores genetic mechanisms underlying resistance to leishmaniasis

In an article published in Scientific Reports, researchers affiliated with the University of São Paulo in Brazil describe experiments performed with mice that show how genetic factors can determine whether an individual is susceptible or resistant to leishmaniasis.

24 Mar 2020

Newly discovered molecule in the lymphatic system could play a role in autoimmune diseases

A study by investigators at Hospital for Special Surgery has discovered a molecule in the lymphatic system that has the potential to play a role in autoimmune disease.

22 Mar 2020

What does COVID-19 do to the body?

The novel coronavirus SARS-CoV-2, also known as 2019-nCoV, is the virus that causes COVID-19, and that is spreading throughout the world is causing panic in almost all countries. With a death rate ranging from 1% to 2% in young patients but about 5%-8% in elderly and sick patients, it is capable of ravaging multiple organ systems in the human body.

12 Mar 2020

New biochemical mechanism in cells is crucial component of anti-aging program

Aging is an inevitable part of life, yet some species are aging very differently than others, even than very similar ones.

11 Mar 2020

Combination of anti-cancer nanodrugs with Intralipid enhances therapeutic efficacy

Pairing chemotherapy nanodrugs with a nutritional supplement can lessen devastating side-effects while reducing the amount of the expensive drugs needed to treat cancer according to a study from Carnegie Mellon University and Taiwan's National Health Research Institutes.

10 Mar 2020

UAB research reveals hydrogen sulfide as new culprit for deadly tuberculosis

A new culprit -- hydrogen sulfide -- has been found for the deadly infectious disease tuberculosis. Hydrogen sulfide gas is known for its rotten egg smell, yet it has normal physiological roles in the human body to communicate among cells.

3 Mar 2020

Collaborative project aims to study red blood cells under physiological flow conditions

Red blood cells (erythrocytes) are the pack animals of the human circulatory system. They transport oxygen to the places in the body where it's needed: to the cells that make up our muscles and organs.

27 Feb 2020

Novartis and DNDi to partner on development of new oral treatment for visceral leishmaniasis

Novartis and the Drugs for Neglected Diseases initiative, a not-for-profit research and development organization, have signed a collaboration and license agreement to jointly develop LXE408, as a potential new oral treatment for visceral leishmaniasis, one of the world's leading parasitic killers.

25 Feb 2020

Guiding nanoparticles directly to the tumor cells

Modern anticancer therapies aim to attack tumor cells while sparing healthy tissue. An interdisciplinary team of researchers at Helmholtz-Zentrum Dresden-Rossendorf and FU Berlin has made important progress in this area: the scientists have produced tiny nanoparticles that are designed to specifically target cancer cells.

24 Feb 2020

New Endothelial Cell Atlas can be used to improve treatments for many diseases

New surprising knowledge on endothelial cells in a dozen different murine tissues is now available in an open access, user-friendly, database for professionals.

20 Feb 2020

Finding the origins of angiosarcoma

In a new study published in the journal Nature Medicine on February 2020, scientists report some newly discovered reasons for the occurrence of a rare blood vessel wall cancer called angiosarcoma. This could one day help develop better therapies for this aggressive tumor. The project is a striking example of unexpectedly rich findings from a crowd-sourced venture that brings together a scattered group of patients with a rare disease.

10 Feb 2020