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Heavy drinking fuels Alzheimer’s disease by igniting brain inflammation and protein damage

Chronic alcohol use accelerates Alzheimer’s disease (AD) progression by intensifying oxidative stress, neuroinflammation, and amyloid-tau pathology through shared molecular pathways. The review highlights emerging therapies, targeting TLR4, GSK-3β, and metabolic dysfunction, that may mitigate alcohol-induced neurodegeneration.

20 Oct 2025

Ingestible bioprinter offers minimally invasive tissue repair

Soft tissue injuries of the gastrointestinal tract, like ulcers or hemorrhages, can currently be treated only with some form of surgery, which is invasive and may not result in permanent repair.

16 Oct 2025

Ganoderma lucidum protects against liver damage from high-fat diets

A long-term high-fat diet (HFD) exerts lipotoxic effects on multiple organs, particularly the liver, leading to metabolic diseases.

16 Oct 2025

New insights into how bacteria can drive treatment resistance in oral and colorectal cancer

Researchers from The University of Texas MD Anderson Cancer Center have discovered a previously unknown mechanism that explains how bacteria can drive treatment resistance in patients with oral and colorectal cancer.

16 Oct 2025

UC Irvine develops human-like colon model for precision medicine

Researchers at the University of California, Irvine have developed a 3D human colon model integrated with bioelectronics to aid in colorectal cancer research and drug discovery.

15 Oct 2025

Does eating watermelon lower blood pressure?

Researchers reviewed the role of watermelon as a natural source of L-citrulline and its potential to improve cardiovascular health by enhancing nitric oxide production. While promising effects on blood pressure and arterial stiffness were seen in at-risk groups, long-term and dose-specific studies are still needed to confirm clinical benefits.

15 Oct 2025

What happens when microplastics reach the testes? Study shows autophagy and cell loss

Researchers found that microplastics from everyday plastic tableware accumulate in human semen and, although not linked to semen quality in the full cohort, were associated with altered sperm parameters in specific subgroups. Experimental models confirmed that 50 nm polystyrene particles trigger autophagy and apoptosis via the FOXA1/MAP3K1/p38 pathway, impairing sperm structure and function.

15 Oct 2025

CU Boulder researchers advance miniature laser technology for biomedical imaging

Darwin Quiroz is exploring new frontiers in miniature lasers with major biomedical applications.

14 Oct 2025

Scientists revive diabetic beta cells, revealing a new path to restore insulin function

Researchers demonstrated that pancreatic β cells from type 2 diabetes donors can partially regain glucose responsiveness when cultured outside the diabetic environment. This recovery, driven by specific gene expression changes, identifies JAK inhibitors as potential therapeutic candidates to restore β-cell function.

14 Oct 2025

Study offers new models for understanding the causes of chemo brain

Cancer is a challenging enough diagnosis, but many patients are dealt a second blow, even as they heal: "chemo brain."

13 Oct 2025

Targeting SIRT7 offers new strategy against liver fibrosis

Liver fibrosis, a progressive scarring of the liver tissue, represents a major global health burden with limited treatment options.

10 Oct 2025

Researchers identify key role of lactylation in driving aortic dissection

Recently, a research team led by Professor Jian-Xun Wang and Professor Tao Yu from Qingdao University made a significant breakthrough in understanding the role of lactylation modification in aortic dissection (AD).

10 Oct 2025

Obesity-linked fat vesicles accelerate amyloid aggregation in Alzheimer’s disease

Researchers discuss the role of extracellular vesicles as a potential link between obesity and Alzheimer’s disease.

9 Oct 2025

Taste-based flu test that detects infection within minutes

Researchers examine the effectiveness of a novel taste-based sensor for the early detection of influenza infection.

8 Oct 2025

Live retinal imaging uncovers early signs of diabetic eye disease

A new method of taking microscopic images of a live mouse's retina through the eye allows to record the reaction of brain cells to disease and treatment.

6 Oct 2025

Common food additives may trigger childhood asthma

Researchers utilize metabolomics to investigate the mechanisms underlying the association between food additives and childhood asthma.

6 Oct 2025

Newly discovered mechanism helps leukemia cells to evade the immune system

A research team at Lund University in Sweden has discovered a mechanism that helps acute myeloid leukemia cells to evade the body's immune system.

3 Oct 2025

Harnessing “DNA surgery” to develop therapeutic medicines for genetic liver and heart diseases

Genome editing is increasingly recognized as a leading frontier in biomedical research and an essential driver of healthcare innovation.

30 Sep 2025

Researchers design factor IX variants for short- and long-term Hemophilia B management

After blood vessel damage, effective blood clotting is essential to halt bleeding. However, this process is inefficient in some individuals due to hereditary factors. Hemophilia B, for example, results from a deficiency in coagulation factor IX (FIX), which can lead to prolonged bleeding after injuries or surgery.

30 Sep 2025

Novel biosensing platform provides quantitative graded evaluation of mild to severe liver injury

Real-time monitoring of key biomarkers is a critical prerequisite for early disease diagnosis and personalized therapy. Early detection of liver function impairment particularly relies on the measurement of serum alanine aminotransferase (ALT).

29 Sep 2025

in vivo News and Research

Heavy drinking fuels Alzheimer’s disease by igniting brain inflammation and protein damage

Ingestible bioprinter offers minimally invasive tissue repair

Ganoderma lucidum protects against liver damage from high-fat diets

New insights into how bacteria can drive treatment resistance in oral and colorectal cancer

UC Irvine develops human-like colon model for precision medicine

Does eating watermelon lower blood pressure?

What happens when microplastics reach the testes? Study shows autophagy and cell loss

CU Boulder researchers advance miniature laser technology for biomedical imaging

Scientists revive diabetic beta cells, revealing a new path to restore insulin function

Study offers new models for understanding the causes of chemo brain

Targeting SIRT7 offers new strategy against liver fibrosis

Researchers identify key role of lactylation in driving aortic dissection

Obesity-linked fat vesicles accelerate amyloid aggregation in Alzheimer’s disease

Taste-based flu test that detects infection within minutes

Live retinal imaging uncovers early signs of diabetic eye disease

Common food additives may trigger childhood asthma

Newly discovered mechanism helps leukemia cells to evade the immune system

Harnessing “DNA surgery” to develop therapeutic medicines for genetic liver and heart diseases

Researchers design factor IX variants for short- and long-term Hemophilia B management

Novel biosensing platform provides quantitative graded evaluation of mild to severe liver injury

eBook: Using iPSCs models for human disease research and drug discovery eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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