Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

IMI launches new project that focuses on development of new biomarkers

The University of Zurich coordinates a worldwide research project that focuses on the development of new biomarkers.

15 Apr 2019

FDA approves new treatment for adults with metastatic bladder cancer

The U.S. Food and Drug Administration today granted accelerated approval to Balversa (erdafitinib), a treatment for adult patients with locally advanced or metastatic bladder cancer that has a type of susceptible genetic alteration known as FGFR3 or FGFR2, and that has progressed during or following prior platinum-containing chemotherapy.

12 Apr 2019

Study describes vulnerability shared by large subset of cancer cell lines

Cancer cells adapt to potentially fatal mutations and other molecular malfunctions by adjusting one or more other genes' activity, in the process becoming dependent on those genes for their survival and growth.

12 Apr 2019

Reduced ADK expression can make liver more susceptible to carcinogenic damage

A new study has shown that reduced adenosine kinase expression in the liver can make it more susceptible to carcinogenic damage and the development of liver cancer.

11 Apr 2019

TGen review associates a gene with hepatocellular carcinoma

Hepatocellular carcinoma is a long medical name for the most common form of liver cancer, a malignancy whose incidence has nearly doubled over the past decade, making it the fastest growing type of cancer in the U.S., and the third-leading cause of cancer-related death worldwide.

9 Apr 2019

Unexpected function of enzyme in sounding alarm about liver damage could lead to new treatments

On a normal day, the cells of a human liver do what they do best - making key blood proteins, clearing toxins from the blood and sending their remains down the digestive tract in a never-ending stream of bile.

9 Apr 2019

Vascular changes in the eye reveal early cognitive impairment

Reduced blood capillaries in the back of the eye may be a new, noninvasive way to diagnose early cognitive impairment, the precursor to Alzheimer's disease in which individuals become forgetful, reports a newly published Northwestern Medicine study.

5 Apr 2019

PET images of microglial activation levels could better predict Alzheimer's disease progression

Researchers have discovered a way to better predict progression of Alzheimer's disease. By imaging microglial activation levels with positron emission tomography, researchers were able to better predict progression of the disease than with beta-amyloid PET imaging, according to a study published in the April issue of the Journal of Nuclear Medicine.

4 Apr 2019

AACR Annual Meeting 2019 Highlighted Latest Advances in Cancer Research

On Friday, March 29 to Wednesday, April 3, the Georgia World Congress Center in Atlanta, Georgia, hosted the AACR Annual Meeting 2019.

From 10x Genomics, Inc. 4 Apr 2019

DBS improves patients' cognitive control by increasing power of brain rhythms

In a new study that could improve the therapeutic efficacy of deep-brain stimulation for psychiatric disorders such as depression, a team of scientists shows that, when DBS is applied to a specific brain region, it improves patients' cognitive control over their behavior by increasing the power of a specific low-frequency brain rhythm in their prefrontal cortex.

4 Apr 2019

ADDF’s new initiative aims to advance digital tools for Alzheimer's and dementias

As part of its Diagnostics Accelerator research program, the Alzheimer's Drug Discovery Foundation announced today a new initiative that aims to fast-track the development of digital tools for Alzheimer's disease and related dementias.

4 Apr 2019

Research demonstrates clinical utility of ddPCR-powered liquid biopsy at 2019 AACR Annual Meeting

New research demonstrating the clinical utility of Bio-Rad's Droplet Digital PCR powered liquid biopsy will be presented this week during the 2019 American Association for Cancer Research Annual Meeting in Atlanta, March 29-April 3.

30 Mar 2019

New combination therapy found to be well tolerated in patients with aggressive brain tumor

A phase I clinical trial that set out to assess the safety of a new combination therapy for a type of aggressive brain tumour has found the treatment to be well tolerated in patients.

30 Mar 2019

Preterm babies born without a protein in blood cells have higher risk of cerebral palsy and death

Researchers at the University of Illinois at Chicago have found that some preterm babies born without haptoglobin, a protein in blood cells, have higher odds of brain bleeding, cerebral palsy and death. Their findings suggest that the absence of the protein could serve as a potential biomarker indicating a need for increased monitoring or other preventive interventions.

30 Mar 2019

IASLC 2019 Small Cell Lung Cancer Meeting focuses on immunotherapy and patient perspective

While non-small cell lung cancer is the more common form of lung cancer and attracts the lion's share of the research funding, recent developments in small cell lung cancer may be shifting that slightly.

29 Mar 2019

Tumor biomarker EpCAM shown to be promising target for cancer immunotherapy

Researchers have shown that cancer immunotherapy targeting the tumor biomarker epithelial cell adhesion molecule is safe and nontoxic in mice and can significantly delay tumor formation and growth.

28 Mar 2019

Quanterix appoints Amol Chaubal as Chief Financial Officer

Quanterix announced that it has named Amol Chaubal to the position of Chief Financial Officer, effective April 12, 2019.

From Quanterix 28 Mar 2019

Exercise helps prevent cartilage degradation caused by osteoarthritis, study shows

Exercise helps to prevent the degradation of cartilage caused by osteoarthritis, according to a new study from Queen Mary University of London.

27 Mar 2019

C-Path and Japan's PMDA join forces on first-of-its-kind biomarker project

Critical Path Institute announced today that a formal consultation between its Predictive Safety Testing Consortium and Japan's Pharmaceuticals and Medical Devices Agency has resulted in an agreement on a first-of-its-kind approach to compare the levels of eight novel urinary kidney safety biomarkers in healthy Japanese volunteers to data collected on these same biomarkers in healthy Western volunteers in a bridging study.

27 Mar 2019

Prostate cancer cells 'spit out' a protein that promotes tumor growth

Prostate cancer cells change the behavior of other cells around them, including normal cells, by 'spitting out' a protein from their nucleus, new research has found.

26 Mar 2019