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DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

New study unveils Foxp3's role in regulatory T cell chromatin architecture

Regulatory T cells are specialized immune cells that suppress the immune response and prevent the body from attacking its own cells.

6 Nov 2023

Kicking the habit: Oral microbiota bounces back five years after quitting smoking

Study finds that smoking reshapes the oral microbiome by favoring anaerobic bacteria, potentially contributing to health risks, yet the effects may reverse if smoking is ceased for over five years, restoring a microbiota similar to that of non-smokers.

5 Nov 2023

Tobacco smoking undermines anti-cancer safeguards by causing harmful DNA mutations

Scientists at the Ontario Institute for Cancer Research (OICR) have uncovered one way tobacco smoking causes cancer and makes it harder to treat by undermining the body's anti-cancer safeguards.

3 Nov 2023

Time-lapsed images show how magnesium ions coordinate double-stranded breaks in CRISPR-Cas9

The gene-editing technology known as CRISPR has led to revolutionary changes in agriculture, health research and more.

2 Nov 2023

Study reveals how formaldehyde alters gene expression through epigenetics

Epigenetics, the chemical mechanisms that controls the activity of genes, allows our cells, tissues and organs to adapt to the changing circumstances of the environment around us.

2 Nov 2023

Researchers discover new mechanism of cancer treatment resistance

A surprising mechanism that makes some cancers treatment-resistant has been discovered by Weill Cornell Medicine and NewYork-Presbyterian investigators.

2 Nov 2023

Tufts researchers explore the science of aging

Anti-wrinkle creams, superfoods that keep you young, dietary supplements that promise improved memory, "immortal" cells that can renew themselves forever - in our stores and media, claims about aging abound.

2 Nov 2023

Gene editing breakthrough could offer new hope for people with phenylketonuria

Phenylketonuria (PKU) is a rare newborn genetic disease that impacts between 1 in 10,000 to 1 in 20,000 people, depending on the individuals' genetic ancestry. PKU causes an amino acid - called phenylalanine (Phe) - to build up in the bloodstream.

2 Nov 2023

Study sheds light on origins of breast cancer in people with BRCA2 mutations

A pioneering study led by Professor Ashok Venkitaraman from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore and Dr Mona Shehata from the University of Cambridge (UK) has uncovered vital insights into the distinct effects of BRCA2 mutations on breast tissue cells, shedding light on early breast cancer development in people with BRCA2 mutations.

1 Nov 2023

Added calcium and phosphate in fluoride varnishes no silver bullet for fighting kids' tooth decay, study finds

The study explores the effectiveness of sodium fluoride varnishes with added calcium and phosphate versus conventional varnishes in reducing harmful bacteria in preschool children's mouths. Results indicate no significant difference between the two types of varnishes in controlling bacterial growth, calling for more research on effective ways to combat early childhood caries.

1 Nov 2023

New study provides insights about mosaic chromosomal alterations in diverse populations

As people age, the DNA in their cells begins to accumulate genetic mutations. Mosaic chromosomal alterations (mCAs), a category of mutations acquired in blood cells, are linked with a 10-fold increased risk of developing blood cancer.

1 Nov 2023

Study finds epigenetic signature for obesity susceptibility in human twins

A susceptibility to gain weight may be written into molecular processes of human cells, a Washington State University study indicates.

1 Nov 2023

New gene editing method creates first mice with human-like COVID-19

Researchers have genetically engineered the first mice that get a human-like form of COVID-19, according to a study published online November 1 in Nature.

1 Nov 2023

PacBio announces Kinnex RNA Kits, further scaling HiFi Sequencing in Full-Length RNA, Single-Cell RNA and 16S rRNA applications

PacBio today announced it has begun taking orders for its groundbreaking Kinnex RNA kits, which increase throughput for full-length RNA, single-cell RNA, and 16S rRNA sequencing on PacBio’s long-read sequencing systems to enable large-scale studies at a resolution difficult to attain with short-read RNA sequencing.

From PacBio 1 Nov 2023

Proof-of-concept study holds promise for safer gene therapy techniques for treating immunodeficiencies

Researchers described an approach to edit the recombination-activating gene 2 (RAG2) locus for therapeutic applications.

1 Nov 2023

3D organization of DNA can influence glioblastoma progression, study reveals

A pioneering study at Umeå University, Sweden, has unveiled that the 3D organization of DNA can influence the progression of the aggressive brain tumor known as glioblastoma.

1 Nov 2023

How one gene shakes up our understanding of male infertility

The study investigates the role of the ACTL7B gene in sperm formation using genetically modified mice and finds that deficiencies in this gene lead to failed spermatogenesis and structural sperm abnormalities. Given the gene's similarity in humans, the findings suggest ACTL7B could serve as a potential biomarker for male infertility.

31 Oct 2023

Speeding up Alzheimer's research: Progerin turbocharges cellular models for quicker drug screening

The study reveals that introducing progerin, a protein associated with accelerated aging, into cellular models of Alzheimer's Disease (AD) can hasten the development of AD-related traits. This innovative approach offers a more efficient method for studying AD mechanisms, potentially accelerating the discovery of new treatments.

31 Oct 2023

Sickle cell disease patients willing to accept high risks for gene therapy cure

Individuals living with severe sickle cell disease (SCD) are highly interested in new, potentially curative gene therapy treatments and are willing to accept associated risks for a chance at a cure, according to a study published today in Blood Advances.

31 Oct 2023

Unbiased proteomic analysis reveals fibroinflammatory landscape of the aging ovary

A new priority research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 20, entitled, "Proteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent fibro-inflammatory signature."

31 Oct 2023

DNA News and Research

Further Reading

New study unveils Foxp3's role in regulatory T cell chromatin architecture

Kicking the habit: Oral microbiota bounces back five years after quitting smoking

Tobacco smoking undermines anti-cancer safeguards by causing harmful DNA mutations

Time-lapsed images show how magnesium ions coordinate double-stranded breaks in CRISPR-Cas9

Study reveals how formaldehyde alters gene expression through epigenetics

Researchers discover new mechanism of cancer treatment resistance

Tufts researchers explore the science of aging

Gene editing breakthrough could offer new hope for people with phenylketonuria

Study sheds light on origins of breast cancer in people with BRCA2 mutations

Added calcium and phosphate in fluoride varnishes no silver bullet for fighting kids' tooth decay, study finds

New study provides insights about mosaic chromosomal alterations in diverse populations

Study finds epigenetic signature for obesity susceptibility in human twins

New gene editing method creates first mice with human-like COVID-19

PacBio announces Kinnex RNA Kits, further scaling HiFi Sequencing in Full-Length RNA, Single-Cell RNA and 16S rRNA applications

Proof-of-concept study holds promise for safer gene therapy techniques for treating immunodeficiencies

3D organization of DNA can influence glioblastoma progression, study reveals

How one gene shakes up our understanding of male infertility

Speeding up Alzheimer's research: Progerin turbocharges cellular models for quicker drug screening

Sickle cell disease patients willing to accept high risks for gene therapy cure

Unbiased proteomic analysis reveals fibroinflammatory landscape of the aging ovary

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