Nephrology News and Research

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Nephrology is a branch of internal medicine and pediatrics dealing with the study of the function and diseases of the kidney.

Researchers aim to protect kidneys while improving cisplatin's efficacy against cancer

Cisplatin is a common, powerful chemotherapy agent used for a wide range of cancers such as breast, ovarian and lung, that in a handful of days can also permanently damage or destroy patients' kidneys.

14 Jun 2016

Liraglutide drug effectively decreases cardiovascular disease risk in type 2 diabetes patients

Researchers have shown that the glucose-lowering drug liraglutide safely and effectively decreases the overall risk of heart attack, stroke, or cardiovascular death for people with type 2 diabetes.

14 Jun 2016

GPCR-Gβγ inhibition therapy could prevent chronic and acute kidney damage in heart failure patients

A study in the Journal of the American Society of Nephrology suggests a new therapeutic approach to treat the development of chronic kidney disease secondary to chronic heart failure, known as cardiorenal syndrome type 2.

14 Jun 2016

Study opens up new strategy to make immunotherapy more effective for different cancer types

By combining local radiation therapy and anti-cancer vaccines with checkpoint inhibitors, researchers from the University of Chicago, working with mice, were able to increase the response rate for these new immunotherapy agents.

14 Jun 2016

'Hypertensive urgency' may cause unnecessary alarm

Patients with a very high blood pressure reading in the absence of other symptoms are highly unlikely to have a major adverse cardiovascular event within the next 6 months, researchers report.

14 Jun 2016

Many children, young adults with migraines appear to have mild vitamin deficiencies

A high percentage of children, teens and young adults with migraines appear to have mild deficiencies in vitamin D, riboflavin and coenzyme Q10 -- a vitamin-like substance found in every cell of the body that is used to produce energy for cell growth and maintenance.

13 Jun 2016

Scientists identify gene linked to severe glaucoma in children

Northwestern Medicine and University of Wisconsin-Madison scientists have identified a gene that causes severe glaucoma in children.

13 Jun 2016

Low birth weight, stress during pregnancy can lead to long-term health issues in women

Low birth weight or stress during pregnancy can lead to long-term health problems in women, according to a study published today in The Journal of Physiology.

13 Jun 2016

ACCORDION study shows lowering blood glucose can reduce progression of diabetic retinopathy

People with type 2 diabetes who intensively controlled their blood sugar level during the landmark Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial Eye Study were found to have cut their risk of diabetic retinopathy in half in a follow-up analysis conducted four years after stopping intensive therapy.

13 Jun 2016

About 30% of iPSCs not safe for clinical use, report multi-institutional researchers

As the promise of using regenerative stem cell therapies draws closer, a consortium of biomedical scientists reports about 30 percent of induced pluripotent stem cells they analyzed from 10 research institutions were genetically unstable and not safe for clinical use.

10 Jun 2016

Carfilzomib therapy shows promise for pre-kidney transplant patients

Early findings by researchers at the University of Cincinnati College of Medicine suggest that the use of a second generation cancer drug, carfilzomib, may provide an improved approach for the reduction of antibodies in potential kidney transplant candidates.

10 Jun 2016

Study highlights role of intestinal calcium absorption in kidney stone formation

Measuring intestinal calcium absorption may help to identify individuals who are prone to develop kidney stones, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology.

10 Jun 2016

UCLA scientists develop statistical method for conducting survival analysis of cancer patients

People with cancer are often told by their doctors approximately how long they have to live, and how well they will respond to treatments, but what if there were a way to improve the accuracy of doctors' predictions?

9 Jun 2016

Mathematical approach can help achieve optimal dosing for various drugs

In treating diseases with drugs, dosing is critical; too little is ineffective, while too much can be lethal. Colorado State University's Brad Reisfeld takes a mathematical approach to achieving optimal dosing for various drugs.

9 Jun 2016

Researchers investigate causes of renal failure using mathematical model

No one can deny that open-heart surgery, where the heart is exposed and the blood is made to bypass it, is one of the most invasive of all medical procedures. Nearly a third of all patients undergoing heart surgery experience kidney failure, yet little is known about why kidney injury occurs or how to prevent it.

9 Jun 2016

Researchers identify lymphatic endothelial lineage that shows potential for new anti-cancer treatment

Identifying the cell of origin is crucial to understanding how a tumor develops and metastasizes and for developing targeted therapies.

8 Jun 2016

Study finds differences in hospitalization trends for gout and rheumatoid arthritis

While hospitalizations related to rheumatoid arthritis have dropped considerably over the past two decades, hospitalizations primarily associated with gout have increased dramatically.

8 Jun 2016

TAVI matches SAVR for early and midterm mortality

Transcatheter aortic valve implantation has similar early and midterm mortality to surgical aortic valve replacement in patients with aortic stenosis, including those at low to intermediate risk, show results of a systematic review and meta-analysis.

8 Jun 2016

Nivolumab drug benefits metastatic RCC patients who continued treatment beyond progression

In a large randomized study, the immunotherapy drug nivolumab, a checkpoint inhibitor, was shown to be a safe and effective therapy for kidney cancer even in patients who continued treatment after their disease progressed.

7 Jun 2016

Overtesting for HbA1C levels can increase risk of severe hypoglycemia

With a more-is-better mindset common in society, frequent commercials encouraging checks of glycated hemoglobin (HbA1C) levels, and ads for new diabetes medications to lower HbA1C in adults with Type 2 diabetes, Mayo Clinic researchers were not too surprised to find overtesting occurring.

7 Jun 2016

Nephrology News and Research

Further Reading

Researchers aim to protect kidneys while improving cisplatin's efficacy against cancer

Liraglutide drug effectively decreases cardiovascular disease risk in type 2 diabetes patients

GPCR-Gβγ inhibition therapy could prevent chronic and acute kidney damage in heart failure patients

Study opens up new strategy to make immunotherapy more effective for different cancer types

'Hypertensive urgency' may cause unnecessary alarm

Many children, young adults with migraines appear to have mild vitamin deficiencies

Scientists identify gene linked to severe glaucoma in children

Low birth weight, stress during pregnancy can lead to long-term health issues in women

ACCORDION study shows lowering blood glucose can reduce progression of diabetic retinopathy

About 30% of iPSCs not safe for clinical use, report multi-institutional researchers

Carfilzomib therapy shows promise for pre-kidney transplant patients

Study highlights role of intestinal calcium absorption in kidney stone formation

UCLA scientists develop statistical method for conducting survival analysis of cancer patients

Mathematical approach can help achieve optimal dosing for various drugs

Researchers investigate causes of renal failure using mathematical model

Researchers identify lymphatic endothelial lineage that shows potential for new anti-cancer treatment

Study finds differences in hospitalization trends for gout and rheumatoid arthritis

TAVI matches SAVR for early and midterm mortality

Nivolumab drug benefits metastatic RCC patients who continued treatment beyond progression

Overtesting for HbA1C levels can increase risk of severe hypoglycemia

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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