Preclinical News and Research

RSS

First National Preclinical Imaging Centre established in Ireland to enhance medical research

A new National Preclinical Imaging Centre which will provide enhanced research data to inform new clinical trials that aim to improve patient outcomes, has been awarded funding of €3.4 million under the Science Foundation Ireland Research Infrastructure Programme.

16 Jun 2020

Abnormal expression of Zeb2 protein in epithelial cells can induce colorectal cancer

A collaborative study by research groups from the VIB-UGent Center for Inflammation Research and Ghent University uncovered a new mechanism causing colorectal cancer.

16 Jun 2020

Cascade Chemistry selected to help speed clinical testing of promising investigational drug for COVID-19

Cascade Chemistry, a leading contract research and manufacturing organization serving the pharmaceutical, materials, and chemical industries, today announced that it has been selected to produce the active pharmaceutical ingredient for clinical trial supplies of RBT-9, an investigational therapy entering a Phase 2 trial for the treatment of COVID-19 patients who are at high risk of deteriorating health due to age or comorbid conditions such as kidney or cardiovascular disease.

16 Jun 2020

Temple researchers receive $1.77M grant to explore therapy for cocaine addiction

Cocaine is a highly addictive drug - some people are unable to walk away from it after just one use. And once addicted, users can lose control of their lives.

15 Jun 2020

Hydroxychloroquine ineffective in animal SARS-CoV-2 infection

A new study by scientists from the U.S and U.K. and published on the preprint server bioRxiv in June 2020 reports that there is no evidence of efficacy for the drug hydroxychloroquine (HCQ) against infection with SARS-CoV-2 in hamsters or macaque models. This finding does not support the current widespread prophylactic and therapeutic use of HCQ in COVID-19.

14 Jun 2020

Steroidal drugs subvert SARS-CoV-2 interaction with ACE2 receptors

A new study by Italian researchers and published online on the preprint server bioRxiv* in June 2020 reports the ability of several existing steroidal drugs to reduce the binding of the SARS-CoV-2 to the ACE2 receptor. This could help define newer strategies using viral entry blockers to reduce viral load.

14 Jun 2020

Hydroxychloroquine shows no antiviral effect on SARS-Cov-2 in non-human primate models

A study on the effects of hydroxychloroquinei n macaques infected with the SARS-CoV-2 virus, , used alone or in combination with azithromycin, have been pre-published on Research Square, after their submission to Nature.

12 Jun 2020

Texas Heart Institute and 7 Hills Pharma receive $1.9 million to improve stem cell transplants

The Texas Heart Institute and 7 Hills Pharma received a $1.9 million, Phase II STTR (R42) grant from the National Heart Lung Blood Institute to advance further their lead product 7HP349, a novel integrin activator, to define the optimal dosing schedule for cord blood transplant along with a focus on development and production of a formulation that meets safety standards for filing an IND application with the FDA.

12 Jun 2020

Beta adrenergic agonists can help decrease risk of graft vs. host disease in alloBMT recipients

New preclinical work by a team of researchers from Roswell Park Comprehensive Cancer Center's Transplant and Cellular Therapy Program suggests that the risk of developing acute graft vs. host disease during allogeneic blood/marrow transplant - a potentially curative treatment for selected patients with hematologic disorders - can be decreased using an existing class of drugs called beta adrenergic agonists.

12 Jun 2020

Scientists find potential new way to improve treatment for Von Willebrand Disease

Scientists have found a potential new way to promote blood clotting that could be used to help develop treatments for Von Willebrand Disease, the most common genetic bleeding disorder.

12 Jun 2020

Researchers evaluate survivin expression in neuroendocrine tumors

Volume 11, Issue 23 of @Oncotarget reported that tissue microarrays of 132 patients were stained for survivin using immunohistochemistry and correlated with outcomes.

10 Jun 2020

Cellular mechanophenotyping may provide more comprehensive view of the tumor

Our ability to predict who will get cancer, how a patient will respond to treatment, or if a patient will relapse is still quite limited. Despite advances in the detection of genetic mutations and the establishment of risk factors, such as age and genetic variants, it remains a great scientific and medical challenge.

9 Jun 2020

Photodynamic therapy can be used in many types and localizations of tumors

As co-author, Research Associate Ayrat Bilyalov explains, the work on photodynamic therapy has been ongoing for 5 years. The group comprises medical professionals from Kazan Federal University and Medical Center of the Presidential Administration of Kazakhstan.

8 Jun 2020

Using antibodies to detect Alzheimer’s disease

News-Medical speaks to Professor Vendruscolo about his research that uses antibodies to detect Alzheimer's disease, which could help to improve drug discovery.

8 Jun 2020

New strategy may facilitate development of multi-epitope peptide vaccine against SARS-CoV-2

By combining T and B lymphocyte analysis with manufacturability heuristic, researchers from the US and Germany proposed a set of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine peptides to use in subsequent animal studies and clinical trials. Their paper is currently available on the bioRxiv preprint server.

7 Jun 2020

UTEP researchers unlock potential of carbon quantum dots to combat neurological disorders

The contributions of researchers from The University of Texas at El Paso (UTEP) have yielded the first indication that carbon quantum dots, a class of nanoparticles, can be utilized to combat neurological disorders, according to a paper published in the journal Processes as part its special issue on protein biosynthesis and drug design and delivery.

5 Jun 2020

Experts debate over future Parkinson’s disease trial involving growth factors

Growth factors such as glial cell line-derived neurotrophic factor (GDNF) were initially thought to be exciting new treatments for Parkinson's disease (PD), but trials have been disappointing.

5 Jun 2020

Designing a prototype spike protein vaccine for SARS-CoV-2

A recent study published on the preprint server bioRxiv in June 2020 reports the development of a prototype vaccine containing multiple antigenic sites, based on the spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that is causing the current COVID-19 pandemic. If successful, this could lead to the development of an effective, non-allergenic vaccine that induces both humoral and cellular immunity.

4 Jun 2020

Scientists aim to develop a gene-targeting, antiviral agent against COVID-19

A team of scientists from Stanford University is working with researchers at the Molecular Foundry, a nanoscience user facility located at the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab), to develop a gene-targeting, antiviral agent against COVID-19.

4 Jun 2020

Nox4 protein can be used as a marker to predict untreatable kidney cancer

A team of researchers from The University of Texas Health Science Center at San Antonio confirmed the role of a certain protein in the development of high-grade kidney cancer.

4 Jun 2020

Preclinical News and Research

First National Preclinical Imaging Centre established in Ireland to enhance medical research

Abnormal expression of Zeb2 protein in epithelial cells can induce colorectal cancer

Cascade Chemistry selected to help speed clinical testing of promising investigational drug for COVID-19

Temple researchers receive $1.77M grant to explore therapy for cocaine addiction

Hydroxychloroquine ineffective in animal SARS-CoV-2 infection

Steroidal drugs subvert SARS-CoV-2 interaction with ACE2 receptors

Hydroxychloroquine shows no antiviral effect on SARS-Cov-2 in non-human primate models

Texas Heart Institute and 7 Hills Pharma receive $1.9 million to improve stem cell transplants

Beta adrenergic agonists can help decrease risk of graft vs. host disease in alloBMT recipients

Scientists find potential new way to improve treatment for Von Willebrand Disease

Researchers evaluate survivin expression in neuroendocrine tumors

Cellular mechanophenotyping may provide more comprehensive view of the tumor

Photodynamic therapy can be used in many types and localizations of tumors

Using antibodies to detect Alzheimer’s disease

New strategy may facilitate development of multi-epitope peptide vaccine against SARS-CoV-2

UTEP researchers unlock potential of carbon quantum dots to combat neurological disorders

Experts debate over future Parkinson’s disease trial involving growth factors

Designing a prototype spike protein vaccine for SARS-CoV-2

Scientists aim to develop a gene-targeting, antiviral agent against COVID-19

Nox4 protein can be used as a marker to predict untreatable kidney cancer

New Approach Methodologies, the 3Rs and Multimodal Imaging in Preclinical Research - eBook eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics