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Study evaluates the tumor-modulatory effects of opsins on melanoma cancer

Melanopsin (OPN4) is a light-sensing protein found in skin and retina cells. A new study conducted at the University of São Paulo (USP) in Brazil suggests that OPN4 can also participate in the development and progression of melanoma, the most aggressive type of skin cancer.

10 Aug 2022

New CDC Vital Signs report: Less than a third of people diagnosed with hepatitis C get timely treatment

Hepatitis C can cause advanced liver disease, liver cancer, and death and affects millions in the United States.

9 Aug 2022

Exposure to a synthetic “forever chemical” linked to non-viral hepatocellular carcinoma

Exposure to a synthetic chemical found widely in the environment is linked to non-viral hepatocellular carcinoma, the most common type of liver cancer, according to a new study conducted by researchers from the Keck School of Medicine of USC and published in JHEP Reports.

9 Aug 2022

Grape consumption alters gene expression in the brain and has positive effects on behavior and cognition

Recent studies released by Dr. John Pezzuto and his team from Western New England University show "astonishing" effects of grape consumption and "remarkable" impacts on health and on lifespans.

9 Aug 2022

Disruption of the circadian clocks plays a key role in weight gain

Disruption of the circadian clocks that keep the body and its cells entrained to the 24-hour day-night cycle plays a critical role in weight gain, according to a pair of studies by Weill Cornell Medicine investigators.

8 Aug 2022

Boosting vitamin D in individuals with deficiencies likely to reduce chronic inflammation

Inflammation is an essential part of the body's healing process. But when it persists, it can contribute to a wide range of complex diseases including type 2 diabetes, heart disease, and autoimmune diseases.

8 Aug 2022

NIH researchers develop three-dimensional structure of twinkle protein

Researchers from the National Institutes of Health have developed a three-dimensional structure that allows them to see how and where disease mutations on the twinkle protein can lead to mitochondrial diseases.

5 Aug 2022

New recommendations on how to determine eligibility criteria for lung cancer clinical trials

A clinical trial is only as powerful as its participants. For years, researchers have struggled to fill clinical trials and enroll sufficiently diverse groups of patients for results to reflect the broader population, in part because of stringent guidelines on who can participate.

5 Aug 2022

Vitamin B12, folic acid supplements could potentially halt or reverse advanced form of fatty liver disease

Scientists at Duke-NUS Medical School in Singapore have uncovered a mechanism that leads to an advanced form of fatty liver disease - and it turns out that vitamin B12 and folic acid supplements could reverse this process.

5 Aug 2022

Extracellular vesicle-based surface protein assay likely to lead to a better way to detect early-stage hepatocellular carcinoma

Primary liver cancer, the third-leading cause of cancer-related death worldwide, takes more than 30,000 lives in the United States each year. The high mortality rates can be attributed in part to the fact that a significant portion of the patients are detected at a late stage, when potentially curative treatments are no longer an option. Unfortunately, today's screening methods are not able to routinely provide accurate, early detection.

5 Aug 2022

Discovery could prevent insulin resistance and have significant benefits for people with type 2 diabetes

In a potential game changer for patients with type 2 diabetes, a team of researchers at the Diabetes, Obesity, and Metabolism Institute (DOMI) at the Icahn School of Medicine at Mount Sinai has identified a therapeutic target for the preservation and regeneration of beta cells (β cells) - cells in the pancreas that produce and distribute insulin.

4 Aug 2022

Using native microbes as chassis for transgene delivery in live bacterial therapeutics

Residing within the human gut are trillions of bacteria and other microorganisms that can impact a variety of chronic human ailments, including obesity, type 2 diabetes, atherosclerosis, cancer, non-alcoholic fatty liver disease and inflammatory bowel disease.

4 Aug 2022

Monoclonal antibody protects U.S. adults from malaria, Phase 1 clinical trial shows

One injection of a candidate monoclonal antibody (mAb) known as L9LS was found to be safe and highly protective in U.S. adults exposed to the malaria parasite, according to results from a National Institutes of Health Phase 1 clinical trial published in The New England Journal of Medicine.

4 Aug 2022

Mice study reveals hepatic consequences of exposure to endocrine disrupting chemical mixtures

We are increasingly being exposed to endocrine-disrupting chemicals (EDCs) that interfere with the normal functioning of our hormones. Bisphenol A (BPA) and phthalates, which are widely used in consumer products including plastics, aluminum cans, pharmaceuticals, and cosmetics, are well-known EDCs.

4 Aug 2022

Inexpensive, self-driven microfluidic chip rapidly detects Hepatitis C virus in about 45 minutes

Hepatitis C affects more than 354 million people worldwide. About 75 to 85 percent of people who have it get a long-term infection referred to as chronic Hepatitis C. Left untreated, it could lead to cirrhosis, liver cancer or liver failure.

3 Aug 2022

Turning to Organ-on-a-Chip Studies for the Future of Drug Discovery

In this interview, we speak to Tom Kostrzewski, VP of Science and Technology at CN Bio, about their organ-on-a-chip product and the future of drug discovery.

From CN Bio 3 Aug 2022

Study pinpoints a three-pronged approach that makes liver cancer cells stop growing

Liver cancer's rapid growth leads to a vulnerability in its energy-production and cell-building processes that may be potently exploited with a new combination-treatment strategy, according to a study from researchers at the Perelman School of Medicine at the University of Pennsylvania.

3 Aug 2022

Liver News and Research

Study evaluates the tumor-modulatory effects of opsins on melanoma cancer

New CDC Vital Signs report: Less than a third of people diagnosed with hepatitis C get timely treatment

Exposure to a synthetic “forever chemical” linked to non-viral hepatocellular carcinoma

Grape consumption alters gene expression in the brain and has positive effects on behavior and cognition

Disruption of the circadian clocks plays a key role in weight gain

Boosting vitamin D in individuals with deficiencies likely to reduce chronic inflammation

NIH researchers develop three-dimensional structure of twinkle protein

New recommendations on how to determine eligibility criteria for lung cancer clinical trials

Vitamin B12, folic acid supplements could potentially halt or reverse advanced form of fatty liver disease

Extracellular vesicle-based surface protein assay likely to lead to a better way to detect early-stage hepatocellular carcinoma

Discovery could prevent insulin resistance and have significant benefits for people with type 2 diabetes

Using native microbes as chassis for transgene delivery in live bacterial therapeutics

Monoclonal antibody protects U.S. adults from malaria, Phase 1 clinical trial shows

Mice study reveals hepatic consequences of exposure to endocrine disrupting chemical mixtures

Inexpensive, self-driven microfluidic chip rapidly detects Hepatitis C virus in about 45 minutes

Turning to Organ-on-a-Chip Studies for the Future of Drug Discovery

Study pinpoints a three-pronged approach that makes liver cancer cells stop growing

Drugs with antiviral activity against monkeypox virus

New national guidelines focus on preventing unhealthy weight gain in middle-aged women

ADAR1 mutation sets off biochemical pathways that produce an organ-damaging autoimmune response

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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