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Exosomes yield regenerative benefits equivalent to hiPSC-CCs, shows study

Science has long known that recovery from experimental heart attacks is improved by injection of a mixture of heart muscle cells, endothelial cells and smooth muscle cells, yet results have been limited by poor engraftment and retention, and researchers worry about potential tumorigenesis and heart arrhythmia.

30 Sep 2020

New graphical tool to identify potent neutralizing antibodies against SARS-CoV-2

A new study by researchers at the Indian Institute of Science and the University of Queensland and published on the preprint server medRxiv in September 2020 discusses using a novel tool to identify the most effective among currently known anti-SARS-CoV-2 NAbs.

29 Sep 2020

A study contradicting the phenotypical relationship between plasmablasts and developing neutrophils

A team of scientists from Australia challenges the findings of a recent study by Wilk et al. demonstrating that plasmablasts transdifferentiate into developing neutrophils in severe coronavirus disease 2019 (COVID-19). The Australian study is currently available on the bioRxiv preprint server.

29 Sep 2020

Researchers develop a new substance that can disarm tumor-promoting proteins

The villain in this drama has a pretty name: Aurora - Latin for dawn. In the world of biochemistry, however, Aurora (more precisely: Aurora-A kinase) stands for a protein that causes extensive damage. There, it has been known for a long time that Aurora often causes cancer.

29 Sep 2020

PrimeStore® MTM novel viral transport media successfully evaluated by Public Health England for SARS-CoV-2 inactivation

EKF Diagnostics announces that the novel viral transport media PrimeStore® MTM has been successfully evaluated for effective SARS-CoV-2 inactivation.

From EKF Diagnostics 29 Sep 2020

A special issue on the emerging COVID-19 infection

Acta Pharmaceutica Sinica B publishes special issue on 'Research on Emerging COVID-19 (Target, Mechanism, and Therapeutics)' edited by Hai-Bin Luo, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China; Shilin Chen, Institute of Chinese Materia Medica, Beijing, China and Peiqing Liu, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.

29 Sep 2020

Valproic acid can interact with DNA conformation and regulate gene expression

Results of recent studies involving valproic acid, used for decades as an anti-convulsant drug, show that it can interact with the conformation of DNA and regulate gene expression.

29 Sep 2020

Resveratrol and pterostilbene inhibit SARS-CoV-2 infection in vitro

A team of scientists at the University of Groningen, in the Netherlands, demonstrates that a natural plant product, resveratrol, and its structural analog, pterostilbene, have long-lasting antiviral effects against severe acute respiratory coronavirus 2 (SARS-CoV-2) infection. The study is currently available on the bioRxiv preprint server.

28 Sep 2020

BAT study analyzes the toxicological impact of nicotine pouch products

New research by BAT indicates that modern oral products (MOPs) showed lower toxicity responses in certain assays than traditional cigarettes.

28 Sep 2020

Special formulation of inhaled niclosamide may be effective against SARS-CoV-2

Now in new research published on the preprint server bioRxix*, a novel formulation of the drug Niclosamide (NIC) is observed to be effective against SARS-CoV-2 and MERS-CoV in mouse models; it also protects against methicillin-resistance Staphylococcus aureus pneumonia and inflammatory lung damage.

28 Sep 2020

Bacteria-free method for making SARS-CoV-2 infectious clones

Using a circular polymerase chain reaction, researchers have developed a method for making severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recombinant virus, with the ability to introduce mutations. The research by Japanese scientists is published on the preprint server bioRxiv* in September 2020.

27 Sep 2020

Yale designates three independent laboratories to perform SalivaDirect COVID-19 test

Yale has designated three independent laboratories to perform the university-developed SalivaDirectTM COVID-19 test.

26 Sep 2020

Study identifies hiding place where tumor cells shelter from chemotherapy in childhood leukemia

The stroma of the choroid plexus is one of the locations within the central nervous system (CNS) that serves as a shelter for tumor cells, allowing them to elude chemotherapy and potentially cause subsequent relapses in childhood acute lymphoblastic leukaemia, according to research led by the Complutense University of Madrid.

25 Sep 2020

Women treated with fertility-sparing surgery for ovarian tumors could become pregnant

Women receiving fertility-sparing surgery for treatment of borderline ovarian tumors were able to have children, a study from Karolinska Institutet in Sweden published in Fertility & Sterility shows.

25 Sep 2020

D614G mutation now the dominant variant in the global COVID-19 pandemic

Now, a new study published on the preprint server medRxiv in September 2020 shows that a significant variant characterized by the D614G mutation has higher infectivity, which may account for its rapid rise to the dominant position in all regions where it has emerged.

25 Sep 2020

Study highlights the importance of healthy placental development in pregnancy

The first stages of placental development take place days before the embryo starts to form in human pregnancies. The finding highlights the importance of healthy placental development in pregnancy, and could lead to future improvements in fertility treatments such as IVF, and a better understanding of placental-related diseases in pregnancy.

25 Sep 2020

Researchers use natural pigment for screening cell viability

Synthetic dyes are commonly used to assess the toxicity of chemical compounds in cell cultures. However, these dyes damage cells, rendering the cultures useless for long-term experiments.

25 Sep 2020

Prevalence of SARS-CoV-2 with D614G mutation in a second wave infection in Houston

A recent study reveals that the genetic variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detected in the initial phase of coronavirus disease 2019 (COVID-19) pandemic differ from the variants detected in a massive second wave of infection in Houston, Texas. The study is currently available on the medRxiv preprint server.

24 Sep 2020

AI used to define the cytokine storm implicated in fatal COVID-19

A new study published on the preprint server bioRxiv* in September 2020 reports the use of artificial intelligence (AI) to identify an invariant or universal host immune response found in all viral pandemics so far. The association of this response with severe COVID-19 phenotypes indicates a new understanding of the human immune response in viral pandemics.

24 Sep 2020

NeutrobodyPlex nanobodies help monitor SARS-CoV-2 immune responses

Researchers recently described a set of 11 Nbs derived from an immunized alpaca which showed high-affinity binding to the glycosylated SARS-CoV-2 spike receptor domain (RBD) in a study published in the preprint server bioRxiv.

23 Sep 2020