Protein C News and Research

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Study uncovers roles of certain brain cells in Alzheimer's plaque formation

A study in Nature Neuroscience found that both neurons and oligodendrocytes contribute to amyloid-β plaque burden in Alzheimer's disease, highlighting new therapeutic targets.

7 Aug 2024

Study uncovers how TREM2 R47H mutation affects Alzheimer's plaques

Researchers led by the University of California, Irvine have discovered how the TREM2 R47H genetic mutation causes certain brain areas to develop abnormal protein clumps, called beta-amyloid plaques, associated with late-onset Alzheimer's disease.

6 Aug 2024

Omega-3 fatty acids show potential in protecting brain health in older adults

Researchers assess the role of ω-3 polyunsaturated fatty acids (PUFAs) in reducing white matter lesion accumulation and neuronal integrity degeneration.

6 Aug 2024

Cambridge experts question efficacy and practicality of new amyloid immunotherapy drugs

Cambridge researchers have cast doubt on whether new amyloid immunotherapy drugs will have the desired effect of significantly reducing the impact of Alzheimer's disease.

6 Aug 2024

New target identified for melanoma resistant to current therapies

Some proteins, such as programmed cell death protein 1 (PD1), can stop the immune system from attacking cancer cells and, therefore, support the growth of cancer.

6 Aug 2024

Mini intestines uncover mechanisms behind COVID-19-related diarrhea and potential treatments

Working with human stem cells that form a kind of "mini intestine-in-a-dish," Johns Hopkins Medicine scientists say they have found several molecular mechanisms for COVID-19-related diarrhea, suggesting potential ways to control it.

6 Aug 2024

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

In this interview conducted at Pittcon 2024, we spoke to Professor John Yates about capturing cardiomyocyte cell-to-cell heterogeneity via shotgun top-down proteomics.

From Pittcon 6 Aug 2024

Cap-QuIC: A new visual diagnostic technique for early detection of neurodegenerative diseases

Researchers at the University of Minnesota, have developed a new visual diagnostic technique that can be used to advance early detection for neurodegenerative diseases like Parkinson's disease and similar diseases that affect animals, including Chronic Wasting Disease in deer.

6 Aug 2024

Reduced folate intake enhances metabolic plasticity in aged mice

Folate fortification of staple foods has long been practiced in many countries.

6 Aug 2024

Valproic acid shows promise in reducing COVID-19 severity and hospitalization

Researchers found that valproic acid (VPA), especially when combined with DHA, significantly reduces SARS-CoV-2 infection rates and severity, potentially activating antiviral mechanisms. Epidemiologic data support VPA's role in reducing COVID-19 severity and hospitalization rates.

6 Aug 2024

New bioactive material regenerates high-quality cartilage in the knee joints of large-animal model

Northwestern University scientists have developed a new bioactive material that successfully regenerated high-quality cartilage in the knee joints of a large-animal model.

5 Aug 2024

Rapid, noninvasive tool tracks neurons and biomolecules activated in the brain by psychedelic drugs

Researchers at the University of California, Davis have developed a rapid, noninvasive tool to track the neurons and biomolecules activated in the brain by psychedelic drugs.

5 Aug 2024

Dr. Carrie Elks receives $1.4 million NIDDK grant to explore fat cell communication and insulin resistance

The National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases, or NIDDK, awarded Pennington Biomedical researcher Dr. Carrie Elks a grant of $1.4 million to explore insulin resistance and inflammation in fat cells.

5 Aug 2024

Breakthrough study identifies mechanisms behind glucocorticoid resistance in pediatric B-ALL

Josep Carreras Leukaemia Research Institute B-ALL is the most common paediatric cancer and, over the years and thanks to a very effective treatment based on glucocorticoids, its 5-year survival rates have reached 85% and beyond.

5 Aug 2024

Seaweed antioxidants show promise in preventing Parkinson's disease

Parkinson's disease is a neurodegenerative disease caused by the loss of neurons that produce dopamine, a neurotransmitter involved in motor control and cognitive function.

5 Aug 2024

Mucosal COVID-19 vaccine prevents airborne transmission of SARS-CoV-2

The impact of mucosal versus intramuscular vaccine immunization on airborne infection and transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Syrian hamsters.

5 Aug 2024

FDA accepted PD-L1 inhibitor durvalumab for the treatment of endometrial cancer

On June 14, 2024, the U.S. FDA approved AstraZeneca's Durvalumab (IMFINZI®) for primary advanced or recurrent endometrial cancer with mismatch repair deficiency. Endometrial cancer is the most prevalent gynecologic cancer, with an estimated 66,200 new U.S. cases in 2023.

From Sino Biological Inc. 5 Aug 2024

Cholesterol imbalance linked to neurodegeneration, study suggests potential strategies for intervention

Research highlights how cholesterol imbalances in the brain contribute to neurodegenerative diseases like Alzheimer's, Huntington's, and Parkinson's, suggesting targeted therapeutic interventions.

5 Aug 2024

Revolutionary real-time microscopy unveils secrets of motor protein behavior

A team led by Professor Seo Dae-ha of the Department of Physics and Chemistry at DGIST (President Lee Kun-woo) has developed new real-time microscopy technology and successfully observed the behavior of "motor proteins", which may hold the key to unraveling the efficient material transport strategy of cells.

2 Aug 2024

Study provides novel insights into the molecular mechanisms of melanoma progression

Cong Peng et al., at Department of Dermatology, Xiangya Hospital, Central South University, China, conducted a study titled "NETO2 promotes melanoma progression via activation of the Ca²⁺/CaMKII signaling pathway" that investigates the role of Neuropilin and tolloid-like 2 (NETO2) in melanoma, a deadly form of skin cancer.

2 Aug 2024

Protein C News and Research

Study uncovers roles of certain brain cells in Alzheimer's plaque formation

Study uncovers how TREM2 R47H mutation affects Alzheimer's plaques

Omega-3 fatty acids show potential in protecting brain health in older adults

Cambridge experts question efficacy and practicality of new amyloid immunotherapy drugs

New target identified for melanoma resistant to current therapies

Mini intestines uncover mechanisms behind COVID-19-related diarrhea and potential treatments

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

Cap-QuIC: A new visual diagnostic technique for early detection of neurodegenerative diseases

Reduced folate intake enhances metabolic plasticity in aged mice

Valproic acid shows promise in reducing COVID-19 severity and hospitalization

New bioactive material regenerates high-quality cartilage in the knee joints of large-animal model

Rapid, noninvasive tool tracks neurons and biomolecules activated in the brain by psychedelic drugs

Dr. Carrie Elks receives $1.4 million NIDDK grant to explore fat cell communication and insulin resistance

Breakthrough study identifies mechanisms behind glucocorticoid resistance in pediatric B-ALL

Seaweed antioxidants show promise in preventing Parkinson's disease

Mucosal COVID-19 vaccine prevents airborne transmission of SARS-CoV-2

FDA accepted PD-L1 inhibitor durvalumab for the treatment of endometrial cancer

Cholesterol imbalance linked to neurodegeneration, study suggests potential strategies for intervention

Revolutionary real-time microscopy unveils secrets of motor protein behavior

Study provides novel insights into the molecular mechanisms of melanoma progression

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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