Nephrology News and Research

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Nephrology is a branch of internal medicine and pediatrics dealing with the study of the function and diseases of the kidney.

Gene editing technology helps excise segment of HIV-1 DNA from genomes of living animals

Using gene editing technology, researchers at the Lewis Katz School of Medicine at Temple University have, for the first time, successfully excised a segment of HIV-1 DNA - the virus responsible for AIDS - from the genomes of living animals.

20 May 2016

Simple sarcopenia screening method could easily diagnose severity of heart disease

Researchers from Kumamoto University in Japan have shown that a simple screening method could quickly and easily diagnose the severity of heart disease. The method was originally developed to diagnose sarcopenia, a disease that causes a loss of muscle mass and strength.

19 May 2016

Innovative research technique may help understand early stage kidney disease

UT Dallas scientists are developing an innovative research technique that could help urologists better understand the early stages of kidney disease.

19 May 2016

New lab blood test may help identify HELLP syndrome in pregnant women

A laboratory blood test developed at Johns Hopkins for the diagnosis of a rare genetic red blood cell disorder also shows promise in identifying HELLP syndrome, a life-threatening high blood pressure condition affecting 1 percent of all pregnant women that causes hypertension along with end organ damage, researchers report in the May issue of the journal Experimental Hematology.

19 May 2016

UD scientists merge electronic health records to improve care, clinical outcomes for CKD patients

Electronic health records have the potential to reduce the incidence of medical errors, duplication of tests, and delays in treatment.

19 May 2016

Rural hospitals may work well for straightforward surgeries in relatively healthy patients

They may be in small towns. They may only have a couple of surgeons. But for common operations, they may be safer and less expensive than their larger cousins, a new study finds.

18 May 2016

Potential marker of disease activity identified for eosinophilic esophagitis

Researchers have identified a potential marker of disease activity for a severe and often painful food allergic disease called eosinophilic esophagitis (EoE) - possibly sparing children with EoE the discomfort and risk of endoscopic procedures to assess whether their disease is active.

17 May 2016

Motor protein Myo1c uses actin cytoskeleton as 'track' for Neph1 transport

The motor protein Myo1c binds to Neph1, a protein crucial for ensuring effective filtration by the kidney, and serves as one mode of its cellular transport, according to findings by investigators at the Medical University of South Carolina and their collaborators reported in the May 16, 2016 issue of Molecular and Cellular Biology.

17 May 2016

Study shows inhibition of SHP-2 enzyme can diminish lupus symptoms

Researchers at Beth Israel Deaconess Medical Center have identified an enzyme that is significantly elevated in mouse models of systemic lupus erythematosus and in blood samples of patients with lupus.

17 May 2016

FDA approves additional indication for Eisai's anticancer agent Lenvima in combo with Everolimus for advanced renal cell carcinoma

Eisai Co., Ltd. has announced that its U.S. subsidiary Eisai Inc. has received approval from the U.S. Food and Drug Administration (FDA) for an additional indication for Eisai's in-house developed novel anticancer agent Lenvima (lenvatinib mesylate) in combination with everolimus for the treatment of patients with advanced renal cell carcinoma following one prior anti-angiogenic therapy.

16 May 2016

University of Colorado Boulder combines Raman spectroscopy and nanoindentation for improved materials characterisation

The University of Colorado Boulder, USA, combines Raman spectroscopy and nanoindentation for improved materials characterisation.

From Renishaw plc - Spectroscopy 16 May 2016

Neos announces U.S. launch of Adzenys XR-ODT for ADHD

Neos Therapeutics, Inc., a pharmaceutical company with a late‐stage pipeline of innovative extended-release (XR) product candidates for the treatment of attention-deficit/hyperactivity disorder (ADHD), today announced that Adzenys XR-ODT™ is in distribution channels and is now available to prescribe for patients with ADHD in the United States.

16 May 2016

Myocardial fibrosis linked to adverse cardiovascular outcomes in OSA patients

Myocardial fibrosis could be a future therapeutic target after researchers found it correlated with adverse cardiovascular outcomes in patients with obstructive sleep apnoea (OSA) referred for cardiac magnetic resonance (CMR).

13 May 2016

'Weekend effect’ may contribute to worsening availability of donor kidneys in the U.S

Investigators have uncovered a "weekend effect" contributing to the worsening availability of donor kidneys in the United States. They found that kidneys that would normally be made available for transplantation were less likely to be procured from donors over the weekend (89.5% on the weekend vs. 90.2% during the week).

13 May 2016

Increased trend of surgical intervention for urinary tract stones in the UK

Researchers in Oxford who analyzed recent trends related to urinary tract stones in the UK found a sustained and high prevalence of the condition, with an increased trend to treat patients with surgery.

12 May 2016

New IsoPSA test identifies molecular structural changes in protein biomarkers to detect prostate cancer

A promising new test is detecting prostate cancer more precisely than current tests, by identifying molecular changes in the prostate specific antigen (PSA) protein, according to Cleveland Clinic research presented today at the American Urological Association annual meeting.

12 May 2016

Combination of two compounds found in red grapes, oranges could treat diseases

A combination of two compounds found in red grapes and oranges could be used to improve the health of people with diabetes, and reduce cases of obesity and heart disease.

12 May 2016

Genetic mutations may be key culprit behind ciliopathies, study shows

Scientists have identified genetic mutations that appear to be a key culprit behind a suite of birth defects called ciliopathies, which affect an estimated 1 in 1,000 births.

11 May 2016

Titanium dioxide nanoparticles can have low-level effects on oxidative stress genes

A nanoparticle commonly used in food, cosmetics, sunscreen and other products can have subtle effects on the activity of genes expressing enzymes that address oxidative stress inside two types of cells.

11 May 2016

Potential new intraocular treatment based on RAS manipulation can prevent or reverse diabetic retinopathy

Pathologic changes of the retina caused by diabetes is the leading cause of blindness in working adults. Diabetic retinopathy has no known cure, treatment options are inadequate, and prevention strategies offer limited protection. In the first of its kind, a report in The American Journal of Pathology describes a potential new intraocular treatment based on manipulating the renin angiotensin system (RAS) that both prevents and reverses some characteristics of diabetic retinopathy in a mouse model.

10 May 2016

Nephrology News and Research

Further Reading

Gene editing technology helps excise segment of HIV-1 DNA from genomes of living animals

Simple sarcopenia screening method could easily diagnose severity of heart disease

Innovative research technique may help understand early stage kidney disease

New lab blood test may help identify HELLP syndrome in pregnant women

UD scientists merge electronic health records to improve care, clinical outcomes for CKD patients

Rural hospitals may work well for straightforward surgeries in relatively healthy patients

Potential marker of disease activity identified for eosinophilic esophagitis

Motor protein Myo1c uses actin cytoskeleton as 'track' for Neph1 transport

Study shows inhibition of SHP-2 enzyme can diminish lupus symptoms

FDA approves additional indication for Eisai's anticancer agent Lenvima in combo with Everolimus for advanced renal cell carcinoma

University of Colorado Boulder combines Raman spectroscopy and nanoindentation for improved materials characterisation

Neos announces U.S. launch of Adzenys XR-ODT for ADHD

Myocardial fibrosis linked to adverse cardiovascular outcomes in OSA patients

'Weekend effect’ may contribute to worsening availability of donor kidneys in the U.S

Increased trend of surgical intervention for urinary tract stones in the UK

New IsoPSA test identifies molecular structural changes in protein biomarkers to detect prostate cancer

Combination of two compounds found in red grapes, oranges could treat diseases

Genetic mutations may be key culprit behind ciliopathies, study shows

Titanium dioxide nanoparticles can have low-level effects on oxidative stress genes

Potential new intraocular treatment based on RAS manipulation can prevent or reverse diabetic retinopathy

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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