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Medicare Advantage leads to lower cancer drug costs in colorectal cancer

A new study examining the use of high-cost drugs among patients with colorectal cancer and non-small cell lung cancer found those insured through Medicare Advantage received less expensive cancer drugs compared to others on Traditional Medicare.

10 Jan 2025

Machine learning technique can transform hospital care for long-COVID patients

Across the United States, no hospital is the same. Equipment, staffing, technical capabilities, and patient populations can all differ.

10 Jan 2025

Biglycan and decorin play crucial roles in bone health

Bone tissue is a complex structure, consisting of mineralized collagen fibers and a variety of non-collagenous proteins, including proteoglycans such as biglycan and decorin.

10 Jan 2025

T cells can completely prevent viral infections in humans

Scientists from Duke-NUS Medical School and the Singapore General Hospital have discovered that T cells-white blood cells that can destroy harmful pathogens-can completely prevent viral infection, to an extent previously thought only possible due to neutralizing antibodies.

10 Jan 2025

Breakthrough microscopy technique reveals how antibodies target cancer cells

In blood cancers such as chronic lymphocytic leukaemia, B cells of the immune system multiply uncontrollably.

10 Jan 2025

Machine learning reveals why cancer trials fall short in real-world patients

TrialTranslator uses machine learning to assess cancer RCT generalizability, revealing survival gaps for high-risk patients and enhancing research accuracy.

10 Jan 2025

New biomaterial could redefine recovery from brain and central nervous system injuries

A new electrically active transplantable material that can help to regrow cells in the brain and spinal cord could redefine the recovery prospects of patients who sustain life-altering injuries or suffer from neurodegenerative diseases.

10 Jan 2025

Lower force leads to faster cell movement on aligned collagen fibers

In mechanobiology, cells' forces have been considered fundamental to their enhanced function, including fast migration.

10 Jan 2025

New therapeutic target could boost CAR T-cell therapy success in solid tumors

Russell W. Jenkins, MD, PhD, a physician investigator in the Krantz Family Center for Cancer Research at the Mass General Cancer Center and an assistant professor of Medicine at Harvard Medical School, is senior author of a new study in Cancer Immunology Research, "TBK1 is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids".

10 Jan 2025

RNA nanoparticles offer dual action against prostate tumors

Yang Zhang, PhD, and Jinjun Shi, PhD, both of the Center for Nanomedicine and Department of Anesthesiology, Perioperative and Pain Medicine at Brigham and Women's Hospital, are co-senior authors of a paper published in ACS Nanoscience Au, "Lipid Nanoparticle Delivery of mRNA and siRNA for Concurrent Restoration of Tumor Suppressor and Inhibition of Tumorigenic Driver in Prostate Cancer."

10 Jan 2025

Mussel-inspired nanoparticles for targeted lung cancer therapy

Researchers from POSTECH and Kyungpook National University have developed a novel inhalable therapeutic delivery system for lung cancer, leveraging mucoadhesive protein nanoparticles inspired by the adhesive properties of marine mussels.

9 Jan 2025

Computer model helps tailor CML treatment to individual patients

Which medicine is best when you are affected by cancer? This can vary from person to person. A new method can help people with a specific type of blood cancer get the best medicine for them.

9 Jan 2025

Developing and refining muscle atrophy models for drug discovery

With the intensification of global population aging, muscle atrophy, characterized by the loss of muscle mass and function, has become an important health issue affecting the elderly. Researchers have widely used various animal and cellular models to gain a deeper understanding of the pathophysiological mechanisms of muscle atrophy and develop effective treatment strategies.

9 Jan 2025

A large-scale tongue cancer organoid library for precision oncology

Oral cancer is an increasingly prevalent disease worldwide, with over 300,000 new cases diagnosed each year. Among oral cancers, tongue cancer (TC) is the most common type and often carries a poor prognosis. Surgery combined with chemoradiotherapy is one of the main lines of treatment for high-risk cases of TC.

9 Jan 2025