Preclinical News and Research

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Decreasing early neuroinflammation could slow Alzheimer's progression

In a new animal study examining Alzheimer's disease, researchers found that disease progression could be slowed by decreasing neuroinflammation in the brain before memory problems and cognitive impairment were apparent.

27 Apr 2020

Researchers make breakthrough in understanding cause of rare childhood brain disorders

A new breakthrough in understanding the cause of rare childhood brain disorders has been made by researchers at the University of Sheffield.

27 Apr 2020

Investigational drug may hold benefit for patients with lung and ovarian cancers

In a first-time disclosure of IPN60090, a small-molecule inhibitor of the metabolic enzyme glutaminase (GLS1), researchers from The University of Texas MD Anderson Cancer Center's Therapeutics Discovery division and Ipsen Biopharmaceuticals reported the preclinical discovery and early-stage clinical development of this novel drug. IPN60090, now under investigation in a Phase I trial, may hold benefit for certain patients with lung and ovarian cancers.

27 Apr 2020

Restoring the Sense of Touch

Dr. Patrick Ganzer speaks to News-Medical about his groundbreaking research into restoring the sense of touch using brain-computer interfaces.

24 Apr 2020

Therapeutic antibody successfully prevents metastases in mice with breast or lung cancer

A receptor in the cell layer that lines the blood vessels from the inside stimulates both the formation of new blood vessels in tumors and metastasis.

24 Apr 2020

UAB to join international effort to test drugs for COVID-19

The University of Alabama at Birmingham will join an international effort coordinated by Scripps Research to test drugs for COVID-19.

24 Apr 2020

Research looks at best ways to tackle coronavirus crisis

A new study published in the journal Frontiers in Microbiology in April 2020 discusses the most attractive approaches among the broad spectrum of experimental and theoretical strategies being worked on to counter the COVID-19 pandemic.

24 Apr 2020

Chinese scientists develop two novel compounds that inhibit SARS-CoV-2 main protease

A team of Chinese scientists has recently developed two novel compounds that inhibit the SARS-CoV-2 main protease (Mpro) and one of them is a good drug candidate for further clinical studies.

23 Apr 2020

AMPK activation by anti-diabetes drug promotes survival of dormant breast cancer cells

Most breast cancers utilize the female hormone estrogen to grow, so drug-induced estrogen deprivation is used as a treatment in many patients. However, cancer will recur in one-third of these patients.

22 Apr 2020

Scripps Research established international network to find antiviral compounds against COVID-19

With the COVID-19 pandemic continuing to spread around the globe, Scripps Research has quickly established an international network of collaborating scientific laboratories to leverage ReFRAME, the world's leading drug repurposing collection, to find antiviral compounds against the novel coronavirus.

22 Apr 2020

PiCoVacc vaccine candidate for COVID-19 effective in animal trials

In a new study available on the bioRxiv preprint server, a group of researchers from China report on the pilot-scale production of a purified inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus vaccine candidate (PiCoVacc), shown to induce virus-specific neutralizing antibodies in rats, mice, and non-human primates.

21 Apr 2020

Study: Behavioral intervention is effective in treating language problems in youth with FXS

A UC Davis Health study found more evidence for the efficacy of telehealth-delivered behavioral intervention in treating language problems in youth with fragile X syndrome (FXS).

21 Apr 2020

Bio-Rad Introduces Anti-Ipilimumab Antibodies

Bio-Rad Laboratories, Inc has extended its range of recombinant monoclonal anti-idiotypic antibodies.

21 Apr 2020

Scientists use genomics and bioinformatics to analyze blueprint of novel coronavirus

Australian researchers from the Commonwealth Scientific and Industrial Research Organization (CSIRO) have found a new way to decode the genome of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes COVID-19 disease. This approach could help in drug and vaccine development. Their work titled, "Supporting pandemic response using genomics and bioinformatics: a case study on the emergent SARS-CoV-2 outbreak," is published in the latest issue of the journal Transboundary and Emerging Diseases.

21 Apr 2020

CSIRO researchers unveil new approach to understand evolving SARS-CoV-2 virus strains

Researchers from CSIRO, Australia's national science agency, have unveiled a new approach to analyzing the genetic codes - or the blueprint - of the SARS-CoV-2 virus that causes COVID-19.

20 Apr 2020

Study adds increasing evidence that autoimmunity plays a role in Parkinson's disease

A new study co-led by scientists at the La Jolla Institute for Immunology adds increasing evidence that Parkinson's disease is partly an autoimmune disease. In fact, the researchers report that signs of autoimmunity can appear in Parkinson's disease patients years before their official diagnosis.

20 Apr 2020

Hydroxychloroquine and azithromycin treatment in 80 COVID-19 patients: short-term outcomes

The COVID-19 pandemic is still spreading around the world and affecting nearly 2.4 million people, with over 164,000 dead so far. With neither vaccine nor proven therapeutic drug being available so far, the need of the hour is for effective treatment. Now, a new study reports the potential usefulness of a combination of hydroxychloroquine and azithromycin as a treatment in mild cases of COVID-19 infection and urges the need for further evaluation and widespread use if its findings are confirmed.

19 Apr 2020

A promising antiviral drug to fight COVID-19 pandemic

COVID-19 patients in a clinical trial at Houston Methodist Hospital are responding quickly to the antiviral drug Remdesivir. The trial's criteria allows for the treatment of patients early in their clinical course and, in some cases, at times where they might have otherwise been intubated.

17 Apr 2020

Scripps Research establishes collaborative global effort to rapidly find drugs against COVID-19

With the COVID-19 pandemic continuing to spread across the globe, Scripps Research has quickly established an international network of collaborating scientific laboratories to leverage ReFRAME, the world's leading drug repurposing collection, to find antiviral compounds against the novel coronavirus.

16 Apr 2020

Potential universal Ebola vaccine may neutralize all four harmful virus species

Infectious disease scientists report early development of a potential universal vaccine for Ebola viruses that preclinical tests show might neutralize all four species of these deadly viruses infecting people in recent outbreaks, mainly in Africa.

16 Apr 2020

Preclinical News and Research

Decreasing early neuroinflammation could slow Alzheimer's progression

Researchers make breakthrough in understanding cause of rare childhood brain disorders

Investigational drug may hold benefit for patients with lung and ovarian cancers

Restoring the Sense of Touch

Therapeutic antibody successfully prevents metastases in mice with breast or lung cancer

UAB to join international effort to test drugs for COVID-19

Research looks at best ways to tackle coronavirus crisis

Chinese scientists develop two novel compounds that inhibit SARS-CoV-2 main protease

AMPK activation by anti-diabetes drug promotes survival of dormant breast cancer cells

Scripps Research established international network to find antiviral compounds against COVID-19

PiCoVacc vaccine candidate for COVID-19 effective in animal trials

Study: Behavioral intervention is effective in treating language problems in youth with FXS

Bio-Rad Introduces Anti-Ipilimumab Antibodies

Scientists use genomics and bioinformatics to analyze blueprint of novel coronavirus

CSIRO researchers unveil new approach to understand evolving SARS-CoV-2 virus strains

Study adds increasing evidence that autoimmunity plays a role in Parkinson's disease

Hydroxychloroquine and azithromycin treatment in 80 COVID-19 patients: short-term outcomes

A promising antiviral drug to fight COVID-19 pandemic

Scripps Research establishes collaborative global effort to rapidly find drugs against COVID-19

Potential universal Ebola vaccine may neutralize all four harmful virus species

Event guide: 4th LNP Formulation & Process Development Summit eBook

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Advancing degrader and proximity-based drug development

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Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics