Cell Death News and Research

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DLBCLs resistant to chemotherapy can be reprogrammed to respond using azacitidine

A phase I clinical trial showed diffuse, large B-cell lymphomas (DLBCLs) resistant to chemotherapy can be reprogrammed to respond to treatment using the drug azacitidine, according to a study published in Cancer Discovery, a journal of the American Association for Cancer Research.

17 Aug 2013

Scientists develop new therapies to prevent chemoresistance of established tumours

Cancer cells often develop defence mechanisms which enable them to survive chemotherapy. A group of researchers from the Institutes of Pharmacology and Pathology in Bern present new solutions for preventing the development of such resistances.

17 Aug 2013

GHI research aims to target breast cancer stem-like cells using immunotherapy

New hope is on its way for the fight against breast cancer as Griffith Health Institute research aims to target the disease with immune-based therapies.

16 Aug 2013

Kinetin stops the effects of Parkinson's disease on brain cells, say scientists

The active ingredient in an over-the-counter skin cream might do more than prevent wrinkles. Scientists have discovered that the drug, called kinetin, also slows or stops the effects of Parkinson's disease on brain cells.

16 Aug 2013

Flavonoids in celery, artichokes induce apoptosis in human pancreatic cancer cells

Celery, artichokes, and herbs, especially Mexican oregano, all contain apigenin and luteolin, flavonoids that kill human pancreatic cancer cells in the lab by inhibiting an important enzyme, according to two new University of Illinois studies.

16 Aug 2013

Research suggests Huntington's disease might begin in synapses

The synapses in the brain act as key communication points between approximately one hundred billion neurons. They form a complex network connecting various centres in the brain through electrical impulses. New research from Lund University suggests that it is precisely here, in the synapses, that Huntington's disease might begin.

13 Aug 2013

OGF-OGFr axis can be modulated in human triple-negative breast cancer cells to inhibit proliferation

Researchers at The Pennsylvania State University College of Medicine, led by Dr. Ian S. Zagon, have discovered that a novel biological pathway, the OGF-OGFr axis, can be modulated in human triple-negative breast cancer cells to inhibit proliferation. According to BreastCancer.org 1 in 8 women in the U.S. will develop invasive breast cancer and more than 39,000 deaths occur annually.

12 Aug 2013

New studies in mice support toxic role of aluminum in neurodegenerative conditions

Investigators have linked aluminum accumulation in the brain as a possible contributing factor to neurodegenerative disorders such as Alzheimer's disease. A new study published in Restorative Neurology and Neuroscience sheds light on the mechanism underlying aluminum-induced neuronal cell death and identifies necrostatin-1 as a substance which counteracts several of aluminum's neurotoxic effects.

6 Aug 2013

Study observes that long-term use of antihypertensive drugs associated with breast cancer risk

Older women who take certain types of medication to combat high blood pressure may be putting themselves at greater risk for developing breast cancer, according to a new study by a team of Fred Hutchinson Cancer Research Center scientists led by Christopher Li, M.D., Ph.D.

6 Aug 2013

Necrostatin-1: A substance which counteracts several of aluminum's neurotoxic effects

New Studies in Mice Support Toxic Role of Aluminum in Neurodegenerative Conditions, According to Report in Restorative Neurology and Neuroscience

3 Aug 2013

Study shows blocking dietary sugar in tumor cells may reduce cancer risk and progression

Blocking dietary sugar and its activity in tumor cells may reduce cancer risk and progression, according to researchers from the Icahn School of Medicine. The study, conducted in fruit flies and published in the journal Cell, provides insight as to why metabolism-related diseases such as diabetes or obesity are associated with certain types of cancer, including pancreatic, breast, liver, and colon cancers

2 Aug 2013

Scientists prevent cell sleep to reduce chance of tumor recurrence

An international research team led by University of Pittsburgh Cancer Institute (UPCI) scientists discovered that by preventing cancer cells from entering a state of cellular sleep, cancer drugs are more effective, and there is a lower chance of cancer recurrence.

2 Aug 2013

Trace substance in sugar improves muscle regeneration in mouse model with muscular dystrophy

A trace substance in caramelized sugar, when purified and given in appropriate doses, improves muscle regeneration in a mouse model of Duchenne muscular dystrophy. The findings are published today, Aug. 1, in the journal Skeletal Muscle.

2 Aug 2013

Omega-3 fatty acids can be used for treatment, prevention of skin and oral cancers: Research

Omega-3 fatty acids, contained in oily fish such as salmon and trout, selectively inhibit growth and induce cell death in early and late-stage oral and skin cancers, according to new research from scientists at Queen Mary, University of London.

2 Aug 2013

'Dark matter' in human genome may play role in cancer biology and cell death

The St. Laurent Institute, a non-profit medical research institute focused on the systems biology of disease, today announced in a study published in the July edition of Genome Biology, that genetic matter, previously ignored by the scientific community, may play an important role in cancer.

1 Aug 2013

Novocure uses NovoTTF therapy to treat first recurrent glioblastoma tumor patient

Novocure today announced that Dr. Tatsunori Okamaura, MD, Ph.D., of the Kashiwaba Neurosurgical Hospital in Sapporo, Japan has treated the first patient in Japan with alternating electric field therapy.

1 Aug 2013

Researchers contribute to key step in finding cure for prion-folding diseases in humans

The work of University of Alberta researchers and their teams has contributed to an important next step in finding a cure for deadly prion-folding diseases in humans and animals.

1 Aug 2013

Researchers reveal how SMIP004 anticancer compound targets prostate cancer cells

One major hallmark of cancer cells is their ability to survive under stressful conditions. A new study spearheaded by researchers at Sanford-Burnham Medical Research Institute reveals how a promising anticancer compound called SMIP004 specifically kills prostate cancer cells by compromising their ability to withstand environmental stress.

31 Jul 2013

Male and female rats show different patterns of kidney gene expression throughout their lives

Male and female rats show different patterns of kidney gene expression throughout their lives, a study in the open access journal Biology of Sex Differences reveals. The finding could help explain some of the gender differences observed in human renal disease, and lead to improved biomarkers of kidney function.

31 Jul 2013

Inner ear supporting cells protect hair cells by secreting HSP70

An underlying cause of hearing loss is the death of sensory hair cells in the inner ear, which can be damaged in response to a variety of factors including the use of aminoglycoside antibiotics.

26 Jul 2013

Cell Death News and Research

DLBCLs resistant to chemotherapy can be reprogrammed to respond using azacitidine

Scientists develop new therapies to prevent chemoresistance of established tumours

GHI research aims to target breast cancer stem-like cells using immunotherapy

Kinetin stops the effects of Parkinson's disease on brain cells, say scientists

Flavonoids in celery, artichokes induce apoptosis in human pancreatic cancer cells

Research suggests Huntington's disease might begin in synapses

OGF-OGFr axis can be modulated in human triple-negative breast cancer cells to inhibit proliferation

New studies in mice support toxic role of aluminum in neurodegenerative conditions

Study observes that long-term use of antihypertensive drugs associated with breast cancer risk

Necrostatin-1: A substance which counteracts several of aluminum's neurotoxic effects

Study shows blocking dietary sugar in tumor cells may reduce cancer risk and progression

Scientists prevent cell sleep to reduce chance of tumor recurrence

Trace substance in sugar improves muscle regeneration in mouse model with muscular dystrophy

Omega-3 fatty acids can be used for treatment, prevention of skin and oral cancers: Research

'Dark matter' in human genome may play role in cancer biology and cell death

Novocure uses NovoTTF therapy to treat first recurrent glioblastoma tumor patient

Researchers contribute to key step in finding cure for prion-folding diseases in humans

Researchers reveal how SMIP004 anticancer compound targets prostate cancer cells

Male and female rats show different patterns of kidney gene expression throughout their lives

Inner ear supporting cells protect hair cells by secreting HSP70

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