Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Coriell scientist awarded grant to explore epigenetic drivers of breast cancer

Shoghag Panjarian, PhD, a research scientist at the Coriell Institute for Medical Research, has been awarded a grant from the W. W. Smith Charitable Trust to support her search for epigenetic factors that contribute to the development and growth of breast cancer.

5 Dec 2019

ADDF announces new awards through its Diagnostics Accelerator initiative

The Alzheimer's Drug Discovery Foundation announced six new investments totaling $6 million through its Diagnostics Accelerator initiative.

4 Dec 2019

Epigenomic techniques used to fight disease

Humans differ from one another in many ways, including how they react to disease, because of their DNA blueprint, as well as the difference in the environments they face. These factors combine to make each person unique. Now a new study published in the journal Nature Protocols reports the development of a promising technology to uncover the process by which the body fights diseases in different ways.

4 Dec 2019

A major step toward preventing GvHD in patients receiving bone marrow transplants

A drug used for rheumatoid arthritis has moved a step closer to FDA approval for a desperately needed new use.

4 Dec 2019

Early adherence step in intestinal transit of Shigella discovered

The bacterial pathogen Shigella, often spread through contaminated food or water, is a leading cause of mortality in both children and older adults in the developing world.

4 Dec 2019

Early-morning, starch-rich meal improves glycemic control among type 2 diabetics

Type 2 diabetics inject themselves with insulin, a hormone that regulates the movement of sugar into liver, muscle and fat cells, up to four times a day. But insulin injections are linked to weight gain and the loss of control of blood sugar levels. This triggers a vicious cycle of higher insulin doses, continuous weight gain, a higher incidence of cardiovascular disease and other complications.

3 Dec 2019

Study: Calcium signaling can help address drug resistance to non-Hodgkin lymphoma

Gene expression profiling and other analyses conducted by Rutgers Cancer Institute of New Jersey researchers and colleagues examining drug resistance to a common antibody therapy for non-Hodgkin lymphoma have identified calcium signaling as a novel and exploitable target in overcoming this treatment obstacle.

3 Dec 2019

Discovery could offer insight into different risk of diseases in African Americans

The percentage of African ancestry in a person's genome determines the level that certain genes are expressed, called mRNA, according to a new Northwestern Medicine study.

3 Dec 2019

Daughters of women with PCOS five times more likely to develop the syndrome in adulthood

Daughters of women with polycystic ovarian syndrome are five times more likely to be diagnosed with PCOS as adults, and the generational transmission is driven by high androgen levels during pregnancy, researchers at Karolinska Institutet in Sweden report.

2 Dec 2019

Consortium launches ambitious project to transform the treatment of pain

In an effort to address the critical public health need for new, safer and more effective medicines to treat pain, a consortium based at the Laboratory of Systems Pharmacology at Harvard Medical School has launched an ambitious project titled STOP PAIN (Safe Therapeutic Options for Pain and Inflammation).

2 Dec 2019

Scientists uncover functions of mysterious organelles in stress response

Stress is a normal response to physical and emotional stimuli, particularly when people face changes in their lives. Though it’s a normal feeling, long-term stress may lead to a range of health conditions. Though people feel stressed from time to time, not all stress is bad.

1 Dec 2019

Simple urine test at home could revolutionize diagnosis of prostate cancer

A simple urine test under development for prostate cancer detection can now use urine samples collected at home - according to new research from University of East Anglia and the Norfolk and Norwich University Hospital.

28 Nov 2019

Home urine testing kit for prostate cancer could come soon

A new study from the University of East Anglia and the Norfolk and Norwich University Hospital may lead to people being able to test for prostate cancer from home, using urine samples. The study, which was published in the journal BioTechniques, describes a simple home urine collection test which can detect aggressive prostate cancer, and providing information on whether it requires to be treated, up to 5 years earlier than the comparable diagnostic methods of today.

28 Nov 2019

Changes in placenta could mean males born to older mothers more prone to heart problems

A new study in rats shows that older mother rats develop poorer placentas which are in turn related to later risk of heart problems in their male offspring. The study, published in the journal Scientific Reports, shows that both male and female offspring are smaller in size when the mother is older. However, the placental development in older mothers with male fetuses is especially impaired, leading to worse placental function. As a result, heart problems are more common in later life in these offspring, as is high blood pressure.

28 Nov 2019

Placenta changes in older mothers linked to greater odds of heart problems in male offspring

Placenta changes could mean male offspring of older mums more likely to develop heart problems in later life, rat study finds.

28 Nov 2019

Research could help design better flu vaccines

Each year millions of Americans become sick with the flu, hundreds of thousands are hospitalized and tens of thousands die. Getting the flu shot can reduce the chances of infection. But, at best, the vaccine is only effective 40% to 60% of the time, according to the CDC.

26 Nov 2019

Study points to two types of motion that keeps cells in shape

The health of cells is maintained, in part, by two types of movement of their nucleoli, a team of scientists has found. This dual motion within surrounding fluid, it reports, adds to our understanding of what contributes to healthy cellular function and points to how its disruption could affect human health.

26 Nov 2019

Fertility treatments cause epigenetic changes in mouse embryos, study finds

Though epigenetic disorders - diseases caused by faulty gene expression - are still rare overall, babies born using fertility treatments have up to an 11-fold higher risk of inheriting them.

26 Nov 2019

Researchers discover cellular origins of pediatric brain tumors

A research team led by Dr. Claudia Kleinman, an investigator at the Lady Davis Institute at the Jewish General Hospital, together with Dr. Nada Jabado, of the Research Institute of the McGill University Health Centre, and Dr. Michael Taylor, of The Hospital for Sick Children, discovered that several types of highly aggressive and, ultimately, fatal pediatric brain tumors originate during brain development.

25 Nov 2019

Discovery in C. difficile biology opens new window to developing treatments for dangerous infections

A process called sporulation that helps the dangerous bacterium Clostridium difficile (C. difficile) to survive inhospitable conditions and spread is regulated by epigenetics, factors that affect gene expression beyond the DNA genetic code, researchers at the Icahn School of Medicine at Mount Sinai report.

25 Nov 2019

Gene Expression News and Research

Further Reading

Coriell scientist awarded grant to explore epigenetic drivers of breast cancer

ADDF announces new awards through its Diagnostics Accelerator initiative

Epigenomic techniques used to fight disease

A major step toward preventing GvHD in patients receiving bone marrow transplants

Early adherence step in intestinal transit of Shigella discovered

Early-morning, starch-rich meal improves glycemic control among type 2 diabetics

Study: Calcium signaling can help address drug resistance to non-Hodgkin lymphoma

Discovery could offer insight into different risk of diseases in African Americans

Daughters of women with PCOS five times more likely to develop the syndrome in adulthood

Consortium launches ambitious project to transform the treatment of pain

Scientists uncover functions of mysterious organelles in stress response

Simple urine test at home could revolutionize diagnosis of prostate cancer

Home urine testing kit for prostate cancer could come soon

Changes in placenta could mean males born to older mothers more prone to heart problems

Placenta changes in older mothers linked to greater odds of heart problems in male offspring

Research could help design better flu vaccines

Study points to two types of motion that keeps cells in shape

Fertility treatments cause epigenetic changes in mouse embryos, study finds

Researchers discover cellular origins of pediatric brain tumors

Discovery in C. difficile biology opens new window to developing treatments for dangerous infections

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